Publications by authors named "Yong-Xiang Zhan"
Article Synopsis
- - This study investigated the genetic factors affecting survival duration in Glioblastoma Multiforme (GBM) patients using Next-Generation Sequencing, dividing 30 patients into extended (over two years) and abbreviated (under two years) survival groups.
- - Key mutations identified included CHEK2, IDH1, and TP53, with non-coding variants found in TERT and TP53 RNA splicing sites, although no statistical significance was reached due to the small sample size.
- - Interestingly, TP53 mutations were more common in the longer-surviving group, challenging previous Western findings; however, further research is necessary to explore their functional implications and the role of other mutations in therapeutic strategies.
Ethylene-responsive factors (ERFs) have diverse functions in the regulation of various plant developmental processes. Here, we demonstrate the dual role of an Arabidopsis ERF gene, AtERF19, in regulating reproductive meristem activity and flower organ size through the regulation of genes involved in CLAVATA-WUSCHEL (CLV-WUS) and auxin signaling, respectively. We found that AtERF19 stimulated the formation of flower primordia and controlled the number of flowers produced by activating WUS and was negatively regulated by CLV3.
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