Publications by authors named "Yong-Xia Jiang"
Objective: To explore the effect of electroacupuncture (EA) on the pathomorphology of the sciatic nerve and the role of P2X3 receptors in EA analgesia.
Methods: The chronic constriction injury (CCI) model was adopted in this study. A total of 32 rats were randomly divided into four groups: sham CCI, CCI, CCI plus contralateral EA (CCI + conEA) and CCI plus ipsilateral EA (CCI + ipsEA).
Article Synopsis
- The study aimed to examine the anatomy of Jiaji (EX-B 2) points in the lower lumbar region to determine the best needle insertion angle and depth.
- Thirty male adult spine samples were used to test needle insertions at three distances (1 cun, 0.5 cun, and 0.3 cun) from the lumbar spinous process, while observing nearby blood vessels and nerves.
- Results showed that different insertion depths effectively stimulated the medial ramus of the dorsal primary ramus of the spinal nerve and associated vessels, indicating specific anatomical relationships in the targeted regions.
Adenosine 5'-triphosphate disodium (ATP) gated P2X receptors, especially the subtype P2X(3), play a key role in transmission of pain signals in neuropathic pain, ATP has been documented to play a significant role in the progression of pain signals, suggesting that control of these pathways through electroacupuncture (EA) is potentially an effective treatment for chronic neuropathic pain. EA has been accepted to effectively manage chronic pain by applying the stimulating current to acupoints through acupuncture needles. To determine the significance of EA on neuropathic pain mediated by P2X(3) receptors in the dorsal root ganglion (DRG) neurons, mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were recorded, and the expression of P2X(3) receptors in the DRG neurons was assessed by immunohistochemistry (IHC) and in situ hybridization (ISH).
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