Publications by authors named "Yong-Shan Zheng"
Myeloid-derived growth factor (MYDGF) is a cytokine that exhibits a variety of biological functions. This study focused on utilizing BL21(DE3) strain engineering and fermentation strategies to achieve high-level expression of soluble human MYDGF (hMYDGF) in Escherichia coli. Initially, the E.
View Article and Find Full Text PDFIs myeloid-derived growth factor a ligand of the sphingosine-1-phosphate receptor 2?
Biochem Biophys Res Commun
April 2024
Article Synopsis
- Recent studies suggested that MYDGF might activate the sphingosine-1-phosphate receptor 2 (S1PR2), which is involved in organ repair.
- However, experiments conducted using advanced assays showed that MYDGF does not actually interact with S1PR2 in human cells, indicating it isn’t a ligand for this receptor.
- The findings suggest that MYDGF is likely not a ligand for S1PR2 in other vertebrates either, complicating the understanding of its function.
The ghrelin receptor GHSR has two efficient agonists in the lobe-finned fish Latimeria chalumnae.
Biochem Biophys Res Commun
October 2023
The peptide hormone ghrelin (an agonist) and LEAP2 (an antagonist) play important functions in energy metabolism via their receptor GHSR, an A-class G protein-coupled receptor. Ghrelin, LEAP2, and GHSR are widely present from fishes to mammals. However, our recent study suggested that fish GHSRs have different binding properties to ghrelin: a GHSR from the lobe-finned fish Latimeria chalumnae (coelacanth) is efficiently activated by ghrelin, but GHSRs from the ray-finned fish Danio rerio (zebrafish) and Larimichthys crocea (large yellow croaker) have lost binding to ghrelin.
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