B-site substitution effects on the mechanical properties of halide perovskites [CHN][BCl]·HO (B = NH; K).

The mechanical properties of halide perovskites have been attracting ever-increasing interest for their significant importance in future industrial applications. However, studies focused on the effect of B-site substitution of molecular perovskites on their mechanical properties are rare, which makes it favorable to shed light on their fundamental structure-mechanical property relationships. Here, using isostructural halide perovskites, [CHN][BCl]·HO (B = NH; K), constructed by ionic bonds and hydrogen bonds, respectively, as the model systems, we investigate their mechanical properties through high-pressure synchrotron X-ray diffraction experiments and density functional theory calculations.

Interferon-α induces differentiation of cancer stem cells and immunosuppression in hepatocellular carcinoma by upregulating CXCL8 secretion.

Interferon-alpha (IFN-α) is widely used in the clinical treatment of patients with chronic hepatitis B and hepatocellular carcinoma (HCC). However, high levels of CXCL8 are associated with resistance to IFN-α therapy and poorer prognosis in advanced cancers. In this study, we investigated whether IFN-α could directly induce the production of CXCL8 in HCC cells and whether CXCL8 could antagonize the antitumor activity of IFN-α.

Tumor cell-derived LC3Bextracellular vesicles mediate the crosstalk between tumor microenvironment and immunotherapy efficacy in hepatocellular carcinoma via the HSP90α-IL-6/IL-8 signaling axis.

Background: Inflammatory factors are being recognized as critical modulators of host antitumor immunity in liver cancer. We have previously shown that tumor cell-released LC3B positive extracellular vesicles (LC3B EVs) are responsible for malignant progression by dampening antitumor immunity. However, the relationship between LC3B EVs and inflammatory factors in the regulation of the liver cancer microenvironment remains unclear.

Dual-response fluorescence sensing of HPO and CO using AJP filter paper based on a pH-stable Cd-based luminescent metal-organic framework.

A new Cd-based luminescent metal-organic framework (LMOF) with the formula {[Cd(BIBT)(NDC)]·solvents} (JXUST-32, BIBT = 4,7-bi(1-imidazol-1-yl)benzo-[2,1,3]thiadiazole and HNDC = 2,6-naphthalenedicarboxylic acid) was successfully synthesized by a solvothermal method. JXUST-32 shows a two-dimensional (4,4)-connected network and exhibits significant fluorescence red shift and slight enhancement for HPO and CO sensing with detection limits of 0.11 and 0.

Selective recognition of Hg ions in aqueous solution by a Cd-based metal-organic framework with good stability and vacant coordination sites.

A novel water-stable Cd-based metal-organic framework, namely {[Cd(BIBT)(TDC)]·2HO} (JXUST-28, BIBT = 4,7-bi(1-imidazol-1-yl)benzo-[2,1,3]thiadiazole and HTDC = 2,5-thiophenedicarboxylic acid), was synthesized using a mixed-ligand strategy. Structural analysis demonstrates that JXUST-28 exhibits a two-dimensional layer structure with 4-connected topology. Intriguingly, JXUST-28 presents good stability in boiling water (at least 5 days), common organic solvents and aqueous solutions with different pH values of 2-12 (more than 24 hours).

[Effect of Gegen Qinlian Decoction on methylation and expression of Scd1gene in adipose tissue of insulin resistant rats and correlations between methylation and physiological and biochemical parameters].

This study aimed to explore the effect of Gegen Qinlian Decoction(GQD) on the methylation and mRNA expression level of stearoyl CoA desaturase(SCD) gene in the adipose tissue of rats with insulin resistance(IR) induced by high-fat diet as well as the correlations between methylation and physiological and biochemical indicators. The animals were divided into seven groups, namely, blank control(C) group, IR model group, low-(1.65 g·kg~(-1)), medium-(4.

Thymosin α-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis.

Unlabelled: The immunologic effects of chemotherapy-induced tumor cell death are not completely understood. Accumulating evidence suggests that phagocytic clearance of apoptotic tumor cells, also known as efferocytosis, is an immunologically silent process, thus maintaining an immunosuppressive tumor microenvironment (TME). Here we report that, in the breast tumor microenvironment, thymosin α-1 (Tα-1) significantly reverses M2 polarization of IL10-producing tumor-associated macrophages (TAM) during efferocytosis induced by apoptotic cells.

A Benzothiadiazole-Based Eu Metal-Organic Framework as the Turn-On Luminescent Sensor toward Al and Ga with Potential Bioimaging Application.

The design and preparation of novel multifunctional lanthanide metal-organic frameworks (Ln-MOFs) have been arisen widespread attention. In particular, Ln-MOFs have shown great luminescence potential in chemical sensing. Herein, a new benzothiadiazole-based Eu-MOF {[(CH)NH][Eu(BTDB)]·2HO} () was obtained based on 4,4'-(benzo[][1,2,5]thiadiazole-4,7-diyl)dibenzoic acid (HBTDB), which exhibits a chain-based three-dimensional framework.

Fluorescent sensors for aldehydes based on luminescent metal-organic frameworks.

Volatile aldehydes cause great harm to human health and the living environment, and the detection of aldehydes has attracted much attention from chemists and material scientists. In recent years, as one of the most promising classes of functional materials, luminescent metal-organic frameworks (LMOFs) have bloomed as fluorescent sensors for the detection of aldehydes. Herein, the sensing properties of LMOF sensors toward formaldehyde, benzaldehyde, acetaldehyde and other aldehydes have been reviewed, and the sensing mechanism and applications are also illustrated.

Post-Marketing Surveillance of Qishe Pill () Use for Management of Neck Pain in a Chinese Patient Cohort to Determine its Safety, Tolerability and Effectiveness.

Objective: To evaluate the safety and effectiveness of Qishe Pill () on neck pain in real-world clinical practice.

Methods: A multi-center, prospective, observational surveillance in 8 hospitals across Shanghai was conducted. During patients receiving 4-week Qishe Pill medication, Visual Analogue Scale (VAS) and Neck Disability Index (NDI) assessments have been used to assess their pain and function, while safety monitoring have been observed after 2 and 4 weeks.

[Preliminary study on effect of Gegen Qinlian Decoction on enzyme activity, gene expression and methylation level of FASN in adipose tissue of rats with insulin resistance].

To investigate the effect of Gegen Qinlian Decoction(GQD) on enzyme activity, gene expression and methylation level of fatty acid synthase(FASN) in adipose tissue from rats with insulin resistance induced by high-fat diet. The 60% fat-powered high-fat diet was continuously given to male SD rats to induce the insulin resistance model. Then, they were divided into five groups randomly and administrated by gavage every day for 16 weeks with following drugs respectively: 10 mL·kg~(-1)water for control group(C) and insulin resistance model control group(IR), 1.

Efficacy and Safety of Tongning Gel for Knee Osteoarthritis: A Multicentre, Randomized, Double-Blinded, Parallel, Placebo-Controlled, Clinical Trial.

Objective: To evaluate the efficacy and safety of Tongning Gel (TNG) compared to placebo-controlled (PC) for knee osteoarthritis (KOA).

Methods: A multicentre, randomized, double-blinded, parallel, placebo-controlled, clinical trial was performed in 576 patients (432 patients in the TNG group, 144 patients in the PC group), and 1 in the experimental group withdrew due to nonuse of drug. Patients were randomized to receive TNG or PC applied to knee skin at 3g per time, 2 times per day, which lasted for 3 weeks.

Turn-On Luminescent Sensor toward Fe, Cr, and Al Based on a Co(II) Metal-Organic Framework with Open Functional Sites.

A novel Co-based metal-organic framework (MOF) with the formula of {[Co(BIBT)(BTC)(HO)]·solvents} (, where denotes Jiangxi University of Science and Technology, BIBT = 4,7-bi(1-imidazol-1-yl)benzo-[2,1,3]thiadiazole, and HBTC = 1,3,5-benzenetricarboxylic acid) has been solvothermally prepared, which takes 3D structure with a rare 3,4,6-c topology and contains intramolecular hydrogen bonds. Interestingly, the sensing investigations suggest that could be considered as a multifunctional fluorescence sensor toward Fe, Cr, and Al via a turn-on effect with good reusability and detection limits of 0.13, 0.

Cd -Organic Frameworks Fabricated with a N-Rich Ligand and Flexible Dicarboxylates: Structural Diversity and Multi-Responsive Luminescent Sensing for Toxic Anions and Ethylenediamine.

Three metal-organic frameworks {[Cd(L)(glu)]⋅3 H O} (1), {[Cd (L) (adi) ]⋅5 H O} (2) and {[Cd(L)(sub)]⋅3 H O⋅DMA } (3) (L=pyridine-3,5-bis(5-azabenzimidazole), H glu=glutaric acid, H adi=adipic acid and H sub=suberic acid) were obtained under solvothermal conditions. Complex 1 shows a 2D (4,4) network constructing of Cd -glu and Cd-L chains. Complex 2 presents a 2-fold interpenetrating 3D framework with pcu topology.

Metal/Carboxylate-Induced Versatile Structures of Nine 0D → 3D Complexes with Different Fluorescent and Electrochemical Behaviors.

To investigate the effect of the polycarboxylates and metal ions on the assembly and structures of complexes based on a thiophene-containing bis-pyridyl-bis-amide ,-bis(pyridine-3-yl)thiophene-2,5-dicarboxamide (3-bptpa) ligand, nine 0D → 3D complexes of [Ni(3-bptpa)(1,2-BDC)(HO)] (), [Ni(3-bptpa)(IP)(HO)]·HO (), [Ni(3-bptpa)(5-MIP)(HO)]·HO (), [Ni(3-bptpa)(5-NIP)(HO)] (), [Ni(3-bptpa)(5-AIP)]·2HO (), [Ni(OH)(3-bptpa)(1,3,5-BTC)]·DMA·5HO (), [Cu(3-bptpa)(5-MIP)]·3HO (), [Cu(3-bptpa)(5-AIP)(HO)]·HO (), and [Cu(3-bptpa)(1,3,5-HBTC)] () (1,2-HBDC = 1,2-benzenedicarboxylic acid, HIP = 1,3-benzenedicarboxylic acid, 5-HMIP = 5-methylisophthalic acid, 5-HNIP = 5-nitroisophthalic acid, 5-HAIP = 5-aminoisophthalic acid, DMA = ,'-dimethylacetamide, and 1,3,5-HBTC = 1,3,5-benzenetricarboxylic acid) have been hydrothermally/solvothermally synthesized and structurally characterized by IR, thermogravimetric, powder X-ray diffraction, and single-crystal X-ray diffraction. Complex is a zero-dimensional (0D) bimetallic complex. Complexes and feature two similar one-dimensional ladderlike structures.

Tumor-released autophagosomes induces CD4 T cell-mediated immunosuppression via a TLR2-IL-6 cascade.

Background: CD4 T cells are critical effectors of anti-tumor immunity, but how tumor cells influence CD4 T cell effector function is not fully understood. Tumor cell-released autophagosomes (TRAPs) are being recognized as critical modulators of host anti-tumor immunity during tumor progression. Here, we explored the mechanistic aspects of TRAPs in the modulation of CD4 T cells in the tumor microenvironment.

A Cd -Based Metal-Organic Framework with pcu Topology as Turn-On Fluorescent Sensor for Al.

A new metal-organic framework (MOF) {[Cd (bbib) (ndc) ]⋅2DMF} (JXUST-1) (bbib=1,3-bis(benzimidazolyl)benzene, H ndc=1,4-naphthalenedicarboxylic acid, DMF=N,N-dimethylformamide) has been solvothermally synthesized and characterized by single-crystal X-ray diffraction, PXRD, TGA, IR and elemental analysis. JXUST-1 exhibits a three-dimensional 6-connected pcu topology with a Schläfli symbol {4 .6 } constructed by [Cd (CO ) ] secondary building units.

A Zn-Based Metal-Organic Framework with a Rare tcj Topology as a Turn-On Fluorescent Sensor for Acetylacetone.

A Zn-based metal-organic framework (MOF) with a rare tcj topology has been solvothermally synthesized and displays relatively good thermal and chemical stabilities. Interestingly, the MOF can sensitively and selectively sense acetylacetone (acac) via a fluorescence enhancement effect with a detection limit of 0.10 ppm and good reusability, which demonstrates the first example of a MOF-based turn-on fluorescent sensor for acac.

[DNA methylation in adipose tissue and the development of diabetes and obesity].

Diabetes and obesity are complicated metabolic diseases which frequently occur together and are affected by environmental, hereditary and metabolic factors. Adipose tissue is involved in various physiological and pathological processes and plays an essential role as an endocrine organ which regulates the metabolic balance of the body. DNA methylation of some genes in adipose tissue may have an impact on its function.

The role of plasma miRNAs in the diagnosis of pulmonary nodules.

Background: In this study, we aimed to assess the clinical utility of detection of plasma microRNAs (miRNAs) in the diagnosis of pulmonary nodules.

Methods: Fifty-seven patients with pulmonary nodules who had undergone surgery were enrolled in our study from July 2016 to July 2017 at Sun Yat-sen University Cancer Center. We measured the expression levels of 12 miRNAs (miRNA-17, -146a, -200b, -182, -155, -221, -205, -126, -7, -21, -145, and miRNA-210) in plasma samples of 57 patients, including 15 benign pulmonary nodules patients and 42 malignant pulmonary nodules patients.

[Downregulation of PTTG1 expression inhibits the proliferation and invasiveness and promotes the apoptosis of human prostate cancer LNCaP-AI cells].

Objective: To investigate the effects of down-regulation of PTTG1 expression on the proliferation, invasiveness and apoptosis of androgen-independent human prostate cancer LNCaP-AI cells and their sensitivity to androgen antagonists.

Methods: Human prostate cancer LNCaP-AI cells were transfected with siRNA targeting the PTTG1 gene using the Lipofectamine 2000 transfection reagent. The proliferation, invasiveness and apoptosis of the cells were detected by MTT, Transwell assay and flow cytometry, respectively.