Publications by authors named "Yong-Ping Dai"
Pain in Parkinson's disease (PD) is increasingly recognized as a major factor associated with poor life quality of PD patients. However, classic therapeutic drugs supplying dopamine have limited therapeutic effects on PD-related pain. This suggests that there is a mechanism outside the dopamine system that causes pain in PD.
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- iRBD is a potential early indicator of neurodegenerative diseases, and researchers are investigating how EEG data during REM sleep and RBD severity ratings can predict the progression of these diseases in patients.
- The study involved a detailed analysis of iRBD patients, comparing those who later developed neurodegenerative diseases (iRBD-C) with those who did not (iRBD-NC), looking at sleep patterns, EEG measurements, and clinical assessments.
- Results showed 33.8% of iRBD patients converted to neurodegenerative conditions, with notable differences in sleep duration, sleep stages, and EEG power, highlighting the potential of specific EEG patterns to predict disease conversion while subjective severity ratings were not significant predictors.
Objective: To determine whether the onset of rapid eye movement (REM) sleep behavior disorder (RBD) is associated with changes in brainstem neuronal pathway dysfunction as reflected by vestibular-evoked myogenic potentials (VEMPs) and to evaluate associations between VEMPs and REM sleep without atonia (RSWA) in patients with early-stage Parkinson's disease (PD) and isolated RBD (iRBD).
Methods: Eighty-two early-stage PD patients, 40 iRBD patients, and 41 healthy control individuals underwent one-night video-polysomnography (vPSG) and VEMPs examination. We compared cervical (cVEMP), ocular (oVEMP), and masseter (mVEMP) VEMP parameters among PD with RBD (PD + RBD), PD without RBD (PD-RBD), iRBD, and control groups and analyzed correlations between VEMPs and RSWA in PD and iRBD groups.
Article Synopsis
- The study investigated the link between serum cystatin C (CysC) levels and sleep disturbances in early Parkinson's disease (PD) patients, finding that CysC levels were significantly higher in these patients compared to controls.* -
- They analyzed data from 106 early PD patients and 146 matched controls, using clinical assessments and video-polysomnography to measure sleep quality and serum CysC levels.* -
- Results showed that higher CysC levels in early PD were associated with increased sleep apnea and hypopnea events, as well as oxygen desaturation during sleep, suggesting CysC could be a useful biomarker for sleep issues in these patients.*
Two polysomnographic features of REM sleep behavior disorder: Clinical variations insight for Parkinson's disease.
Parkinsonism Relat Disord
November 2017
Introduction: Loss of REM sleep muscle atonia (RWA) and dream-enactment behavior (DEB) are two associated features of REM sleep behavior disorder (RBD), which is frequently associated with Parkinson's disease (PD). Few studies have examined both DEB and RWA simultaneously in patients with PD. This study aimed to evaluate relationships between RWA, DEB and clinical characteristics of PD.
View Article and Find Full Text PDFObjective: The aim of the present study was to investigate the relationship between rapid eye movement (REM) sleep without atonia (RWA) and Parkinson's disease (PD) progression.
Methods: We quantified tonic and phasic RWA by performing polysomnography in 198 PD patients. We then correlated the extent of RWA with clinical patient characteristics.