Publications by authors named "Yong-Mei Lv"
Background: Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Complement component 4 (C4) has be proved to play a role in pathogenesis of SLE. In the present study, we investigated the effect of C4 on T cells differentiation.
View Article and Find Full Text PDFTwo putative α-D-galactosidases (α-GALs) belonging to glycosyl hydrolase family 27, and originating from the rather unexplored bacterial strain Pedobacter heparinus, were cloned and biochemically characterized. The recombinant enzymes designated as PhAGal729 and PhAGal2920 showed comparable biochemical properties: the optimum pH values were determined to be pH 5.0 and 5.
View Article and Find Full Text PDFBackground: Genome-wide association studies (GWASs) have revealed a large number of genetic risk loci for many autoimmune diseases. One clear finding emerging from the published genetic studies of autoimmunity is that different autoimmune diseases, such as psoriasis and systemic lupus erythematosus (SLE), share susceptibility loci. Our study explores additional susceptibility loci shared by psoriasis and SLE in the Chinese Han population.
View Article and Find Full Text PDFPsoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1 locus (6q21) has been strongly associated with psoriasis; however, it is difficult to identify additional independent association due to strong linkage disequilibrium in the MHC region. We performed stepwise regression analyses of more than 3,000 SNPs in the MHC region genotyped using Human 610-Quad (Illumina) in 1,139 cases with psoriasis and 1,132 controls of Han Chinese population to search for additional independent association.
View Article and Find Full Text PDFLeber's hereditary optic neuropathy (LHON) is a maternally transmitted disease. Clinically, no efficient assay protocols have been available. In this study, we aimed to develop an oligonucleotide biochip specialized for detection of known base substitution mutations in mitochondrial DNA causing LHON and to investigate frequencies of LHON relevant variants in Anhui region of China.
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- Atopic dermatitis is a long-lasting inflammatory skin condition influenced by both genetics and the environment.
- A study involved a genome-wide analysis of atopic dermatitis in a large Chinese Han population and included additional samples from Germany, leading to the identification of new genetic markers associated with the condition.
- The findings reveal new potential genetic factors that contribute to atopic dermatitis and suggest new biological pathways that could be explored for better understanding and treatment.
Article Synopsis
- - We conducted a genome-wide association study for generalized vitiligo focusing on the Chinese Han population, involving over 1,100 cases and almost 1,500 controls, followed by a larger replication study in different Chinese populations.
- - Two significant genetic markers in the major histocompatibility complex (MHC) region were identified, one associated with increased risk (rs11966200) and another potentially protective (rs9468925) related to specific HLA alleles.
- - Additionally, we discovered a new risk locus at 6q27 (rs2236313) linked to three genes, contributing to a better understanding of the genetic factors involved in vitiligo.
Article Synopsis
- A genome-wide association study (GWAS) was conducted on systemic lupus erythematosus (SLE) in a Chinese Han population, involving over 1,000 cases and 1,200 controls, with genetic analysis performed using Illumina technology.
- The study identified nine new genetic susceptibility loci for SLE and confirmed seven previously known loci, showing a significant difference in genetic factors contributing to SLE between Chinese Han and European populations.
- Findings from this research enhance the understanding of SLE's genetic basis and emphasize the importance of studying diverse populations in genetic research.
Vitiligo is a common skin and hair depigmentary disorder that results from selective destruction of melanocytes. It occurs in a typical multifactorial, polygenic inheritance. Several studies have indicated that vitiligo is associated with some autoimmune diseases.
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