Publications by authors named "Yong-Ling Lian"
Front Cell Neurosci
August 2018
Article Synopsis
- Methamphetamine (METH) is an illegal stimulant linked to an increased risk of neurodegenerative disorders like Parkinson's disease due to its effect on alpha-synuclein (α-syn) aggregation.
- The study investigates how high doses of METH influence the SUMOylation of α-syn by measuring various related markers in human neuroblastoma cells, mouse neurons, and METH-exposed mouse brain tissues.
- Results indicate that while METH increases α-syn and SUMO-1 expression, it actually reduces the SUMOylation levels of α-syn, potentially due to decreased UBC9 levels; altering SUMOylation impacts α-syn aggregation induced by METH.
