Publications by authors named "Yong-Le Yu"
Article Synopsis
- Bone macrophages interact with bone marrow mesenchymal stem cells (BMSCs) and their regulation through exosomes is vital for understanding bone-related diseases, especially glucocorticoid-associated osteonecrosis of the femoral head (GA-ONFH).
- Research found an increase in M1 macrophages in GA-ONFH, but the relationship between these macrophages and BMSCs in the context of glucocorticoids is not well understood.
- Results showed that glucocorticoid-stimulated M1 macrophages inhibit the osteogenic differentiation of BMSCs and promote their adipogenic differentiation through exosomes and the microRNA miR-1a-3p.
Article Synopsis
- The research investigates the role of histone deacetylase 10 (HDAC10) in the adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and its implications for steroid-induced avascular necrosis of the femoral head (SANFH).
- Dexamethasone treatment was found to worsen the differentiation balance of BMSCs, with HDAC10 showing significantly reduced expression in adipogenic differentiation models.
- The study suggests that decreased HDAC10 levels lead to increased PPARγ expression, contributing to the progression of SANFH, and highlights potential therapeutic avenues for the condition.
Due to persistent inflammation and oxidative stress reactions, achieving drug absorption in diabetic wounds is challenging. To overcome this problem, our article presents a composite hydrogel, GelMA-GA/DMOG@GDNP, which consists of gelatin methacryloyl (GelMA) treated with gallic acid (GA) and encapsulating ginseng-derived nanoparticles (GDNPs) loaded with dimethyloxallyl glycine (DMOG). The composite hydrogel demonstrates excellent biocompatibility.
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