Publications by authors named "Yong-Khee Guan"
Introduction: Acute promyelocytic leukemia is an oncologic emergency. The limited cases reported in the literature have led to poor understanding of the safety of management of acute promyelocytic leukemia during pregnancy.
Case Report: Herein is an acute promyelocytic leukemia case of a 22-year-old young pregnant woman who had various social problems.
Background: The evolution of molecular studies in myeloproliferative neoplasms (MPN) has enlightened us the understanding of this complex disease consisting of polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). The epidemiology is well described in the western world but not in Asian countries like Malaysia.
Materials And Methods: This retrospective national registry of MPN was conducted from year 2009 to 2015 in Malaysia.
Article Synopsis
- A randomized trial compared filgrastim and pegfilgrastim for peripheral blood stem cell mobilization (PBSCM) in patients receiving cyclophosphamide, analyzing various timing for pegfilgrastim administration.
- Pegfilgrastim given on day 7 resulted in the highest mobilization success rate (70.8%), compared to daily filgrastim (63.6%) and pegfilgrastim on day 3 (47.6%).
- The study found multiple myeloma patients were more successful in mobilization than those with acute leukemia or lymphoma, while pegfilgrastim helped avoid excessive white blood cell increases compared to filgrastim, with no significant difference in recovery times for white blood