Integrating data mining and network pharmacology for traditional Chinese medicine for drug discovery of diabetic peripheral neuropathy.

The purpose of this study was to examine the therapeutic potential of core traditional Chinese medicine (CTCM) in the treatment of diabetic peripheral neuropathy (DPN) through the use of a data-driven approach that combined network pharmacology and data mining. Important components of traditional Chinese medicine (TCM) and the targets that correspond with them were found through the examination of numerous databases and clinical prescriptions. The possible therapeutic pathways were investigated, with an emphasis on the AGE-RAGE pathway that was discovered via network pharmacology analysis.

[Mechanism of electroacupuncture penetration needling for relieving synovial inflammation of knee osteoarthritis through TLR4/MyD88/NF-κB signal pathway].

Objective: To observe the effects of electroacupuncture (EA) penetration needling on Toll-like receptors 4/myeloid differentiation factor 88/nuclear factor-kappa B (TLR4/MyD88/NF-κB) signaling pathway in rat synovium and the serum-related inflammatory factors, so as to explore the mechanism of EA penetration needling on synovial inflammation in rats with knee osteoarthritis (KOA).

Methods: SD male rats were randomly divided into sham-operation group, model group, EA+penetration needling group, and conventional EA group, with 16 rats in each group. The rats model was prepared by anterior cruciate ligment transection and these rats were forced to exercise for 8 weeks after operation.

Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathways.

Ischemic stroke is the third most common cause of death and the leading cause of disability worldwide in adults. The antiepileptic drug valproic acid (VPA) was reported to protect cerebral ischemia/reperfusion injury. However, the action mechanism of VPA in cerebral ischemia/reperfusion injury has not been fully understood.

Boronate-functionalized hydrogel as a novel biosensing interface for the glycated hemoglobin A1c (HbA) based on the competitive binding with signaling glycoprotein.

According to recent increases in public healthcare costs associated with diabetes mellitus, the development of new glycemic monitoring techniques based on the biosensing of glycated hemoglobin A1c (HbA), a promising long-term glycemic biomarker, has become a major challenge. In the development of HbA biosensors for point-of-care applications, the selection of an effective biorecognition layer that provides a high reaction yield and specificity toward HbA is regarded as the most significant issue. To address this, we developed a novel HbA biosensing interfacial material by the integration of boronate hydrogel with glass fiber membrane.

[A cohort study on the relationship between cerebrovascular hemodynamic changing and risk of stroke].

Objective: To study the role of cerebrovascular hemodynamic indexes (CVHI) changing in stroke and to provide reference for stroke prevention and risk factor study.

Methods: From 2003 to 2004, participants aged 40 years and above in two communities in Fengxian district were recruited by cluster sampling. Risk factors of stroke and CVHI were investigated and checked during baseline investigation.

Bioelectrocatalytic detection of glycated hemoglobin (HbA1c) based on the competitive binding of target and signaling glycoproteins to a boronate-modified surface.

We developed an electrochemical glycated hemoglobin (HbA(1c)) biosensor for diagnosing diabetes in whole human blood based on the competitive binding reaction of glycated proteins. Until now, no studies have reported a simple and accurate electrochemical biosensor for the quantification of HbA(1c) in whole blood. This is because it is very difficult to correctly distinguish HbA(1c) from large amounts of hemoglobin and other components in whole blood.

[Study on over-weight, obesity and the exposure to stroke risk factors among 40 year olds and over in a community-based population].

Objective: To describe the distribution of over weight and obesity to discover the level of exposure on risk factors of stroke among people aged 40 and over, in a community-based population.

Methods: From 2003 to 2004, people aged > or = 40 years in a community of Fengxian district in Shanghai were selected by cluster sampling. Out of 11,791 individuals who were selected, 10,565 met the inclusion criteria and responded to the investigation.

[Baseline study and analysis on a stroke risk factor-related cohort in Fengxian county of Shanghai].

Objective: To explore the exposed level of stroke risk factors in Fengxian county of Shanghai and the relationships between risk factors and stroke.

Methods: Community based populations including 10,565 individuals aged 40 years old and over were cluster sampled from Fengxian county in 2003 or 2004. Status of exposure on common risk factors such as hypertension, cardiovascular disease, diabetes, family history of stroke, cigarette smoking, alcohol intake were gathered while cerebral vascular hemodynamic index (CVHI) was examined, with CVHI score below 75 points as abnormal.

[Baseline study on a stroke-related cohort in the rural community of Shanghai].

Objective: To present data from a baseline investigation on stroke-related cohort population in rural area of Shanghai.

Methods: A cross-sectional study was carried out in a cluster sampling population aged 40 years and over. General information and data on common risk factors in the population were gathered and cerebral vascular hemodynamic indexes were checked.

[Effectiveness of Nao'an Capsule on stroke prevention among high risk population in Nanhui, Shanghai].

Objective: To evaluate the effectiveness of stroke prevention among high risk population, using Nao'an Capsules.

Methods: Participants were selected from 696,558 residents in Nanhui, using county of Shanghai city. Individuals aged 35 years old and over with at least one risk factor exposure to stroke, received cerebral vascular hemodynamic examination.

[The relationship between hypertension and cerebral hemodynamic scores of vascular function accumulative].

Objective: To probe into the relationship between hypertension and hemodynamic score of cerebral vascular accumulative function by though studying the history of hypertension and level of blood pressure.

Methods: The database of blood pressure and cerebral vascular hemodynamic indexes (CVHI) were from baseline data and measurement in a cohort. 18,512 participants who met the included criteria were enlisted in the study.

[Distribution of cerebral vascular hemodynamic indexes].

Objective: To describe the distribution of cerebral vascular hemodynamic indexes (CVHI).

Methods: A number of 25,355 age 35 and over were selected in the Northeast China by cluster sampling. CVHI were checked during baseline survey and were followed to see the occurrence of stroke.

[Principal component analysis and integral methods of cerebral vascular hemodynamic parameters].

Objective: To establish a predicting model for stroke according to cerebral vascular hemodynamic indexes and major risk factors of stroke.

Methods: Participants selected from a stroke cohort with 25,355 population in China. The first step was to carry out principal component analysis using CVHI.

[The reference range of cerebrovascular hemodynamics indexes parameters].

Objective: To study the reference range of cerebrovascular hemodynamics indexes (CVHI) in a sampling population.

Methods: Fourteen thousand, four hundred and eighty participants without history of stroke or exposure to risk factors were screened from 26 cities in Northeast China, North China, East China, Northwest China, South China, and Southwest China in the prospective study on stroke intervention. CVHI were checked and 95% confidence intervals were calculated using normal distribution methods, which were grouped by age, sex, area, and check positions.

[Changes of cerebral vascular hemodynamics from normal population to stroke].

Objective: To probe into changes of cerebral vascular hemodynamics indexes (CVHI) from normal population to different clinical stage before and after occurring of stroke.

Methods: Participants were selected from 25,355 stroke cohort study population aged 35 years and over in Northeast of China and 55 acute stroke patients were selected from Fuzhou PLA General Hospital. CVHI indexes were checked during baseline investigation or within one week after acute stroke.

[A cohort study on cerebral vascular hemodynamics accumulative score and risks of stroke].

Objective: To estimate relative risk (RR) of cerebral vascular hemodynamics indexes (CVHI) accumulative score as well as some other risk factors of stroke.

Methods: A cohort study was carried out in 25 355 participants aged 35 and over in Northeast of China from 1994 to 2001. In the baseline survey, exposure rates of hypertension, diabetes, family history of stroke and hypertension, etc.