Synopsis of recent research by authors named "Yong-Jie Lian"
- Yong-Jie Lian's research primarily investigates the role of high mobility group box 1 (HMGB1) in the pathogenesis of depression, focusing on how different redox states of HMGB1 and associated neuroinflammatory pathways influence depressive behaviors and cognitive dysfunction.
- Significant findings in Lian's studies demonstrate that chronic stress can activate the kynurenine pathway via HMGB1, thereby contributing to depressive-like symptoms, and that pharmacological interventions, such as glycyrrhizic acid, can alleviate depression by modulating this pathway.
- Lian also explores the intersection of mental health and metabolic disorders, investigating the comorbidity of depression with conditions like type 2 diabetes and how inflammatory processes link these illnesses, further highlighting the role of cytokines in depression's etiology.
