Publications by authors named "Yong-Hong Ai"
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.
Li-Dong Wang Fu-You Zhou Xue-Min Li Liang-Dan Sun Xin Song Zhi-Cai Liu Yong-Hong Ai Hai-Yan Wang Hai-Lin Liu Hai Liu Long-Tang Bai Ai-Fang Ji Ruo-Bai Lin Tai-Jiang Liu Wan-Cai Yang Zhi-Ming Cai
Nat Genet
September 2010
Article Synopsis
- A genome-wide association study was conducted on esophageal squamous cell carcinoma (ESCC) involving 1,077 ESCC patients and 1,733 control subjects, focusing on the Chinese Han population.
- The study successfully replicated findings in larger cohorts, identifying two new genetic risk factors for ESCC: PLCE1 and C20orf54, with strong statistical significance.
- PLCE1 is linked to essential cellular functions like growth and apoptosis, while C20orf54 is involved in riboflavin transport, highlighting their potential roles in ESCC and gastric cardia adenocarcinoma (GCA) risk.