Detection of K-ras gene mutation in fecal samples from elderly large intestinal cancer patients and its diagnostic significance.

Aim: To study the diagnostic significance of K-ras gene mutations in fecal samples from elderly patients with large intestinal cancer.

Methods: DNA was extracted in the fecal and tissue samples from 23 large intestinal cancer patients, 20 colonic adenomatoid polypus patients and 20 healthy subjects. The K-ras gene mutations at the first and second bases of codon 12 were detected by the allele specific mismatch method.

Colonoscopic screening and follow-up for colorectal cancer in the elderly.

Aim: To improve the prevention and treatment of senile patients with colorectal cancer by evaluating the importance of colonoscopy in clinical screening and follow-up.

Methods: Clinical screening of colonoscopy was performed for 2196 patients aged 60-90 years old according to the protocol,and 1740 of them (79.2%) were followed-up.