Introduction: This systematic review examines how extreme temperatures impact Chronic Obstructive Pulmonary Disease (COPD) morbidity and mortality, focusing on identifying vulnerable subpopulations.
Methods: We conducted a systematic literature search from January 1, 2000, to November 6, 2024, across databases like PubMed, MEDLINE and EMBASE, Web of Science, and Scopus, focusing on observational studies that quantitatively defined extreme temperatures and their impacts on COPD morbidity and mortality. Out of 3140 records, 25 studies met the inclusion criteria.
Background And Aim: We investigated the effects of brief, intense stair climbing on cardiorespiratory fitness (CRF) and cardiometabolic risk factors in young Korean men with obesity.
Methods And Results: Twenty-four healthy men (age: 25.8 ± 2.
Membrane proteins play central roles in cell physiology and are the targets of over 50% of FDA-approved drugs. In the present study, we prepared single alkyl-chained triglucosides decorated with multiple pendants, designated multiple pendant-bearing glucosides (MPGs), to enhance membrane protein stability. The new detergents feature two and four pendants of varying size at the hydrophilic-lipophilic interfaces, designated MPG-Ds and MPG-Ts, respectively.
View Article and Find Full Text PDFDysbiosis in gut microbiota and abnormalities in bile acids have been linked to neurodegenerative diseases. While many studies have focused on the relationship between colonic bacteria and Alzheimer's disease (AD), this study propose that alterations in the small intestine microbiota may play a more critical role. This is because the small intestine is pivotal in recycling bile acids through enterohepatic circulation.
View Article and Find Full Text PDFAim: To synthesize and analyze the relationship between empowerment and job satisfaction among nurses in the cultural context using an umbrella review.
Background: Empowerment improves individual autonomy, rights, and responsibilities, allowing employees to feel more control and accountability in their work and improving job satisfaction. Cultural differences also influence perceptions of power and responsibility, affecting empowerment, acceptance, and job satisfaction.
BACKGROUND : Colorectal polypectomy is operator dependent, with variable rates of complete resection. The currently available assessment tools do not provide specific competency-based evaluation of provider technique. We aimed to validate the Global Polypectomy Assessment Tool (GPAT), a novel competency assessment tool for colorectal polypectomy.
View Article and Find Full Text PDFStevens-Johnson Syndrome is a rare disorder of the skin and mucous membranes accompanied by systemic symptoms that are life threatening and require immediate intervention. We sought to determine if different hospital types, specifically urban nonteaching hospitals versus urban teaching hospitals, have different outcomes among patients presenting with Stevens-Johnson Syndrome during hospitalization. Patients presenting to urban teaching and urban nonteaching hospitals were compared.
View Article and Find Full Text PDFIntroduction: Intracranial aneurysm rupture is associated with high mortality and disability rates. Early detection is crucial, but increasing diagnostic workloads place significant strain on radiologists. We evaluated the efficacy of a deep learning algorithm in detecting unruptured intracranial aneurysms (UIAs) using time-of-flight (TOF) magnetic resonance angiography (MRA).
View Article and Find Full Text PDFFerritin is a versatile biomolecule used in various medical applications such as drug delivery, vaccines, biological imaging, and diagnostics. The purity and concentration of the ferritin nanoparticles are crucial for achieving excellent outcomes. In this study, we expressed and purified the recombinant swine ferritin heavy chain (rsFTH) as a new candidate for recombinant ferritin nanoparticles.
View Article and Find Full Text PDFIntroduction: Acute radiation dermatitis (ARD) is a common side effect experienced during radiation therapy (RT) for cancer. Published clinical trials for ARD use a myriad of assessment tools and outcomes to measure ARD severity, which limits the comparability of clinical trial results. Our study utilized a modified Delphi consensus survey to gather expert opinions on commonly used tools for ARD severity.
View Article and Find Full Text PDFOrganic micropollutants in drinking water can pose a public health risk. Chemical analysis alone cannot capture the full range of contaminants or assess their associated risks, promoting the growing use of bioanalytical tools as a complementary approach. This study assessed a drinking water treatment plant in the Nakdong River basin, Korea, using in vitro bioassays targeting nine endpoints.
View Article and Find Full Text PDFAs leading countries in the battery market implement regulations on electric vehicle battery recycling and reuse, value chains for these processes are being developed. In particular, the operation of recycling and reuse businesses begins with the collection of electric vehicle batteries, which is currently left to the free market. This study explored the design of electric vehicle battery collection programs, focusing on the growing number of retired electric vehicle batteries.
View Article and Find Full Text PDFObjective: In this pilot study, we investigated the effects of bright light therapy on depression in schizophrenia using a quasi-experimental design involving random assignment.
Methods: We included patients with schizophrenia who had stable psychiatric symptoms. Experimental group (n = 16) received light therapy while control group (n = 12) received only regular indoor light.
Background: Drug-related death is a significant public health challenge in the United States (U.S.).
View Article and Find Full Text PDFJ Plast Reconstr Aesthet Surg
February 2025
Head and neck reconstruction is among the most expensive types of surgery, requiring long operation time and hospital stays, with high complication rates. Enhanced recovery after surgery improves the quality of post-operative recovery. In this study, we evaluated and compared the costs and outcomes in patients who underwent free flap reconstruction after head and neck cancer surgery with or without enhanced recovery.
View Article and Find Full Text PDFNanomaterials applied in industrial processes and environmental fields usually demand immobilization and recovery strategies that often result in functionality loss and added operational costs. Nanoconfinement, the spatial restriction of nano-sized particles within a larger porous substrate, not only can address critical challenges and sustainability concerns in environmental nanotechnology but also offers unique opportunities otherwise inaccessible by unconfined, bulk-phase nanomaterials. In this perspective, we propose mesoporous silica (mSiO) as an innovative framework for spatially confining metal nanoparticles in a well-controlled manner, offering an effective nanoconfinement engineering strategy for sustainable water management and environmental applications.
View Article and Find Full Text PDFBackground: Protein tyrosine kinase 7 (PTK7) overexpression in lung cancer is associated with tumor progression. Cofetuzumab pelidotin (Cofe-P) is an antibody-drug conjugate comprising an anti-PTK7 antibody conjugated to a microtubule inhibitor. Herein, we report the results of a phase 1b study evaluating Cofe-P safety, efficacy, and pharmacokinetics in patients with recurrent non-small cell lung cancer (NSCLC).
View Article and Find Full Text PDFIntroduction: Cortical paired associative stimulation (cPAS), repeated at spaced intervals and applied to the primary motor cortex (M1) and posterior parietal cortex (PPC), has a dose-dependent effect on corticomotor excitability in young adults. The present study investigated whether aging affects this additive (nonhomeostatic) metaplasticity by performing the same manipulation in a sample of older adults.
Methods: In the multi-dose cPAS condition, three consecutive sessions of the Hebbian-plasticity-induction cPAS protocol were administered with a 50-minute interval between sessions.
In the phase 3 POLARIX study, polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) improved progression-free survival (PFS) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with previously untreated diffuse large B-cell lymphoma (DLBCL). This post hoc subgroup analysis of POLARIX evaluated the efficacy and safety of Pola-R-CHP versus R-CHOP in elderly patients ≥60, ≥65, ≥70, and ≥75 years. As of June 15, 2022 (median follow-up 40 months), 629 patients ≥60 years were included (Pola-R-CHP, n = 311; R-CHOP, n = 318).
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