A novel panel of serum miR-21/miR-155/miR-365 as a potential diagnostic biomarker for breast cancer.

Purpose: Insufficient sensitivity and specificity prevent the use of most existing biomarkers for early detection of breast cancer. Recently, it was reported that serum microRNAs (miRNAs) may be potential biomarkers in many cancer diseases. In this study, we investigated whether serum levels of 5 miRNAs including miR-21, miR-125b, miR-145, miR-155, and miR-365 could discriminate breast cancer patients and healthy controls.

One new antitumour cassane-type diterpene from Caesalpinia crista.

1α-acetoxy-5α, 7β-dihydroxycassa-11,13(15)-diene-16,12-lactone, a new cassane-type diterpene was isolated from Caesalpinia crista. The structure of this compound was elucidated by analysis of NMR spectra, and the relative configuration was established by NOE experiment. The new compound was evaluated for antitumour activity against T47D, DU145 and showed significant inhibitory activities.

Clinicopathologic characteristics and prognosis of young patients with breast cancer.

Background: The aim was to describe the clinicopathological features and prognosis of young patients with breast cancer.

Patients And Methods: We reviewed the records of 1478 consecutive patients aged ≤50 years with first diagnosis of invasive breast cancer referred to surgery from January 1999 to March 2005. A total of 174 patients were aged <35 years (group I) and 1304 were aged 35-50 years (group II).

(Z)-2-Hydr-oxy-3-(4-methoxy-phen-yl)acrylic acid.

In the structure of the title compound, C(10)H(10)O(4), inversion dimers linked by pairs of O-H⋯O hydrogen bonds link the carboxylic acid groups. Further O-H⋯O links cross-link the dimers into sheets running along the b-axis direction.

(Z)-2-Acetamido-3-(4-chloro-phen-yl)acrylic acid.

In the title compound, C(11)H(10)ClNO(3), the mol-ecule consists of a benzene ring and an acetamido-acrylic acid unit on opposite sides of the C=C double bond. In the crystal, inter-molecular O-H⋯O and N-H⋯O hydrogen bonds assemble the mol-ecules into infinite two-dimensional ribbons. These ribbons are linked into a network by inter-molecular C-H⋯π contacts.

To tell or not to tell: attitudes of Chinese oncology nurses towards truth telling of cancer diagnosis.

Aims And Objectives: To investigate the attitude of oncology nurses towards whether and how to disclose diagnoses to patients with early-stage cancer or terminal illness.

Background: The attitudes of patients and doctors towards the disclosure of cancer diagnosis differed from culture to culture. However, little research has focused on the attitudes of Chinese oncology nurses.