Publications by authors named "Yong-Dong Guo"
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) is highly expressed in a variety of malignant tumors and functions as an oncogene; however, its role in colorectal cancer (CRC) remains unclear. We aimed to explore the function and regulatory mechanisms of NUCKS1 and potential therapeutic agents targeting NUCKS1 in CRC. We knocked down and overexpressed NUCKS1 in CRC cells and explored its effects in vitro and in vivo.
View Article and Find Full Text PDFArticle Synopsis
- Transcobalamin (TCN1) is a protein that binds vitamin B12 and is found at high levels in cancer tissues, particularly in colon cancer, linking it to aggressive tumor behavior and poor prognosis.
- The study revealed that TCN1's expression is significantly elevated in colon cancer tissues, correlating with advanced stages and worse patient outcomes based on analyses like Western blotting and immunohistochemistry.
- TCN1's expression decreases after neoadjuvant chemotherapy, suggesting that it could serve as a promising biomarker for assessing colon cancer progression and treatment response.