Simple Synthesis of [F] AV-45 and its Clinical Application in the Diagnosis of Alzheimer's Disease.

Objective: [F] AV-45 can be produced in a simple, stable, and repeatable manner on the Tracerlab FX platform using a self-editing synthetic procedure and solid-phase extraction purification method. This technique is applied to positron emission tomography (PET) imaging of Alzheimer's disease (AD) to observe its distribution and characteristics in various brain regions and its diagnostic efficiency for the disease.

Methods: The precursor was subjected to nucleophilic radiofluorination at 120°C in anhydrous dimethyl sulfoxide, followed by acid hydrolysis of the protecting groups.

Optimization of Automatic Synthesis and Separation of [F] AV-45 and Quality Control.

Based on the Tracerlab FX platform, a synthesis program and preparative high-performance liquid chromatography (HPLC) purification program edited by us can stably and repeatedly produce [F] AV-45 without changing the process. The [F] AV-45 produced meets the main indexes of radiopharmaceutical intravenous preparations. The O-toluene sulfonated precursor (1 mg) was subjected to nucleophilic radiofluorination at 115°C in anhydrous dimethyl sulfoxide (DMSO), then the protective group was hydrolyzed by acid.

Biological characteristics of 18F-FDG PET/CT imaging of cerebral alveolar echinococcosis.

This study aims to analyze the characteristics of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for cerebral alveolar echinococcosis (CAE).Twenty-five CAE patients underwent F-FDG PET/CT, and the diagnosis was confirmed by clinical and surgical pathology. The F-FDG PET/CT results were subject to visual and semiquantitative analysis, and the difference in F-FDG SUVmax for lesions among the 3 types of CAE was evaluated.

[Radionuclide scrotal imaging: an effective method for detecting varicocele].

Objective: To evaluate radionuclide scrotal imaging (RSI) in the diagnosis of varicocele.

Methods: We performed physical examination (PE) and RSI for 126 patients with infertility for at least 12 months and seminal abnormality, obtained the scrotal blood-pool index (SBPI), observed the reflux in the spermatic vein during RSI, typed and graded varicocele by color Doppler flow imaging (CDFI) and compared the results of PE and RSI with those of CDFI.

Results: The rates of sensitivity and specificity of RSI in the diagnosis of varicocele (96.