Novel repetitive elements in plant-specific tails of Gγ proteins as the functional unit in G-protein signalling in crops.

Heterotrimeric G proteins act as molecular switches in signal transduction in response to stimuli in all eukaryotes. However, what specifies G protein signalling in plants and how the mechanism evolved and diverged remain unsolved. Here, we found that the recently evolved tails of three Gγ subunits, Dense and erect panicle 1 (DEP1), G protein gamma subunit 2 of type C (GGC2), and Grain size 3 (GS3), determine their distinct functions and specify grain size in rice (Oryza sativa L.

Incomplete Trisomy Rescue Reveals the Mechanism Underlying Discordance Between Noninvasive Prenatal Screening and Prenatal Diagnosis.

Background: Uniparental disomy (UPD) is a specific type of chromosomal variation in which both chromosomes of a homologous pair are inherited from the same parent. It is responsible for a wide range of disorders. Monosomy rescue and trisomy rescue are the two main hypotheses of UPD generation.

[Retracted] miR‑593 inhibits proliferation and invasion and promotes apoptosis in non‑small cell lung cancer cells by targeting SLUG‑associated signaling pathways.

Following the publication of this paper, and subsequently to the publication of a corrigendum (DOI: 10.3892/mmr.2021.

Analysis risk factors of long-term adverse outcomes and a prediction nomogram for coronary artery disease patients underwent fractional flow reserve.

The role of fractional flow reserve (FFR) in intermediate lesions has been widely used and recommended by guidelines. However, the long-term outcomes in patient with an intermediate stenosis received FFR have not yet been investigated comprehensively. We retrospectively included 558 patients underwent both coronary artery angiography (CAG) and FFR.

Comparative Genomic Analysis of the Poaceae Cytokinin Response Regulator Gene Family and Functional Characterization of in Drought Stress Tolerance in Rice.

The cytokinin (CK) type B response regulator () gene is involved in the CK signaling pathway and performs a key function for mediating reactions to amounts of abiotic stresses. Nevertheless, the gene family remains to be characterized in Poaceae (also known as Gramineae or grasses). Here, we performed a comprehensive analysis encompassing phylogenetic relationships, evolutionary pressures, and expression patterns of the gene family in six Poaceae species, including rice, , , , maize, and wheat.

KDM4B modulates autocrine IL6 in erythroblasts to prevent ineffective erythropoiesis.

Ineffective erythropoiesis (IE) commonly underlies anemia in congenital disorders. However, the causes of IE remain largely unknown. Recently, attention has been drawn to the involvement of nucleated erythrocytes in immune responses, providing a new perspective for exploring the etiology of IE.

HGF-DPSCs ameliorate asthma by regulating CCR1 Th2 cells responses in mice pulmonary mucosa.

Asthma, a prevalent allergic disease affecting approximately 300 million individuals globally, remains a significant public health challenge. Mesenchymal stromal cells (MSCs) and hepatocyte growth factor (HGF), both recognized for their immunomodulatory properties, hold therapeutic potential for asthma. However, their precise mechanisms remain underexplored.

Tandem Synergistic Catalysis on Cu-Pd/BiTiO Nanorods Promoting Highly Selective Photoconversion of CO to Ethyl Alcohol.

The production of high-energy-density liquid fuels through the photoconversion of CO offers a highly efficient method for storing sustainable solar energy for future use. BiTiO (BTO) nanorods loaded with Cu-Pd nanoalloys were designed for the highly selective photoreduction of CO to ethyl alcohol, using HO as the proton source. A tandem synergistic catalysis mechanism was proposed for this CO photoconversion process.

Cryptochromes (CRYs) in pepper: Genome-wide identification, evolution and functional analysis of the negative role of CaCRY1 under Phytophthora capsici infection.

Cryptochromes (CRYs) are ultraviolet-A (UV-A) and blue light photoreceptors that perceive UV-A and blue light to mediate a range of physiological processes including disease response in plants. However, there has been no report about the roles of CRY genes in pepper, which often suffers from Phytophthora blight caused by Phytophthora capsici. In this work, three pepper CRY genes were identified and their characteristics were examined by bioinformatics analysis.

High-Performance FETs with High- STO by Optimized van der Waals Heterostructure Interface.

The pursuit of suitable insulating layers and high-quality integration methods is important to further improve the performance of field-effect transistors (FETs). In this study, we employ transferable high- oxide films as device gate dielectrics to fabricate high-quality optoelectronic devices by optimizing the interface between the dielectric material and the two-dimensional (2D) materials. Through meticulous refinement, a transferred film roughness of 269.

Joint association of remnant cholesterol and lipoprotein-associated phospholipase A2 with composite adverse events: A 12-year follow-up study from Asymptomatic Polyvascular Abnormalities Community study.

Aims: To explore the association of remnant cholesterol (RC) and lipoprotein-associated phospholipase A2 (Lp-PLA2) with composite adverse events in a large-scale prospective study.

Methods: All data were collected from the Asymptomatic Polyvascular Abnormalities Community study between 2010 and 2022. Serum cholesterol levels and Lp-PLA2 were determined by enzyme-linked immunosorbent assay.

Neighboring Chalcogen Bonding for Controlling Dynamic Imine Chemistry in Aqueous Media.

The impact of varied chalcogen bonds (sulfur, selenium, tellurium, and telluronium) on dynamic imine chemistry in aqueous solution is presented by introducing a carboxylate group or cationic telluronium into arylaldehydes. The role of chalcogen bonding in regulating the kinetics and thermodynamics of imine formation/exchange was elucidated through experimental and computational evidence, affording the largest effect for tellurium/telluronium compounds. By leveraging multivalent chalcogen bonding, telluronium-containing aldehyde enabled labeling of the -terminus of amino acids in neutral buffer.

Efficacy of Human Dental-Pulp MSCs Modified by Double-genes on Wound Healing in Diabetic-Foot Model.

Objectives: Diabetic foot (DF) poses a great challenge to us due to its poor therapeutic effect. To seek a new cure, the human dental pulp mesenchymal stem cells (hDP-MSCs) were modified by vascular endothelial growth factor A (VEGFA) and basic fibroblast growth factor (bFGF) (hEDP-MSCs) to investigate their curative effect on DF wound in animal models.

Methods: Forty-eight rats with DF constructed with streptozotocin and ligation of femoral arteries, were randomly divided into six equal groups, which respectively received an intramuscular injection of normal saline (Control group), hDP-MSCs, VEGFA-modified hDP-MSCs, bFGF-- modified hDP-MSCs, hEDP-MSCs, and Ad.

BiVO/BiVO isometallic heterojunction coupled with FeOOH/NiOOH cocatalysts for efficient photoelectrochemical water oxidation.

The four-electron water oxidation reaction in photoelectrochemical systems poses a major challenge to efficiently converting solar energy into chemical energy amid the global energy crisis. Herein, we report a strategy to develop a photoelectrochemical system using BiVO/BiVO isometallic heterojunction photoanodes paired with FeOOH/NiOOH cocatalysts to enhance water oxidation in neutral electrolytes. The results demonstrate that the BiVO/BiVO/FeOOH/NiOOH photoanode achieves a photocurrent density of 4.

Cross-Domain Human Activity Recognition Via Domain Adaptation and Fused Attention.

In recent years, the utilization of wearable sensors for Human Activity Recognition (HAR) has garnered significant interest in the fields of medical health monitoring and sports management. However, HAR often suffer the poor generalization from the insufficient labeled data for complex activities. To address this issue, the novel Transfer Component Analysis-Bidirectional Long Short-Term Memory network (TCA-BiLSTM) with the fused attention mechanism is presented in this paper.

A pan-gene catalogue of Asian cultivated rice.

The rice genome underpins fundamental research and breeding, but the Nipponbare (japonica) reference does not fully encompass the genetic diversity of Asian rice. To address this gap, the Rice Population Reference Panel (RPRP) was developed, comprising high-quality assemblies of 16 rice cultivars to represent , , , and varietal groups. The RPRP has been consistently annotated, supported by extensive experimental data and here we report the computational assignment, characterization and dissemination of stably identified pan-genes.

Microbiome analysis of gut microbiota in patients with colorectal polyps and healthy individuals.

Colorectal polyps serve as the primary precursors for colorectal cancer. A close relationship has been observed between colorectal polyps and gut microbiota. However, the composition and role of the microbiome associated with tubular adenoma are not well understood.

Spin Polarization-Boosting Ultrafast Carrier Dynamics and Exciton Dissociation in Fe Nanoparticle-Loading Graphitic Carbon Nitride Toward Efficient CO Photoreduction.

The regulation of exciton properties plays a crucial role in enhancing the activity of photocatalysts, primarily due to the rapid recombination of photoinduced electron-hole pairs caused by the strong Coulomb interaction between them. In this study, we explore the spin polarization effect in nanohybrids composed of graphitic carbon nitride (g-C₃N₄) and iron (Fe) nanoparticles, which accelerates exciton dissociation and spin-selective electron transfer, thereby improving the selective photoreduction of CO₂ into CO. Mechanistic studies reveal that the Fe⁺/Fe⁺ redox pairs, embedded in the iron oxide layer on the surface of Fe nanoparticles, function as ultrafast charge transfer shuttles via a double exchange interaction (Fe⁺─O─Fe⁺).

Management of a malignant solitary fibrous tumor of lung by uniportal video-assisted pneumonectomy: a case report.

Background: Solitary fibrous tumor (SFT) is a rare condition first described by Klemperer and Robin in 1931. Malignant SFTs account for approximately 80% of all SFT cases, and the five-year survival for malignant SFTs is 81%. Few reports have described SFT management using uniportal video-assisted pneumonectomy.

Chitin-binding mechanism of a CBM73 module derived from a lytic polysaccharide monooxygenase from Vibrio campbellii.

A lytic polysaccharide monooxygenase from Vibrio campbellii (VhLPMO10A) consists of four functional domains including an N-terminal AA10 catalytic domain (CatD) and a C-terminal CBM73 carbohydrate-binding domain. Phylogenetic analysis of CBM73s from AA10 LPMO and GH18/GH19 chitinases revealed that CBM73 from VhLPMO10A (VhCBM73) belongs a clade different from that of a well-studied CBM73 from Cellvibrio japonicus AA10 LPMO (CjCBM73, Madland et al., J.

Unhealthy diet and lifestyle factors linked to female androgenetic alopecia: a community-based study from Jidong study, China.

Background: To explore unhealthy diet and lifestyle factors associated with female androgenetic alopecia (FAGA) in a community-based study.

Methods: A total of 3,008 participants were recruited from the Jidong community (Tangshan, Hebei, China). FAGA was assessed by the Savin scale.

Development of a Thioetherification of Heteroarene Electrophiles with Broad Scope via a Proton Transfer Dual Ionization Mechanism.

Sulfur-derived functional groups represent prevalent motifs in highly sought-after small molecules, such as active pharmaceutical ingredients (APIs). Thioethers are one such example, being commonly encountered in APIs, prodrugs, and as valuable synthetic "linchpins" to access an array of sulfur-derived functional groups. While nucleophilic aromatic substitution (SAr) has traditionally been used to synthesize aryl thioethers, modern approaches leverage transition metals to catalyze thermal or photochemical cross-coupling.

Immunoglobulin M response in largemouth bass () following ranavirus infection.

Immunoglobulin M (IgM) and IgM B cells are key components of the humoral immune system, providing defense against pathogen invasion. While the role of IgM in the systemic and mucosal immune responses of fish to parasites and bacteria has been partially investigated, its function in viral infections remains underexplored. This study successfully developed a largemouth bass () model for ranavirus immersion infection.

Unique NiCo bimetal boosting 98% CH selectivity and high catalysis stability for photothermal CO hydrogenation.

A highly dispersed NiCo alloy catalyst derived from NiCo bimetallic-organic framework nanosheets was synthesized for efficient photothermal catalysis for CO hydrogenation to methane. The NiCo bimetal catalyst achieves a CH production rate of 55.60 mmol g h with only a 18.

Age-related differences in borderline personality disorder traits and childhood maltreatment: a cross-sectional study.

Introduction: This study investigates age-related differences in Borderline Personality Disorder (BPD) traits and childhood maltreatment (CM) experiences among adolescents, young adults, and older adults within a clinical sample.

Methods: A cross-sectional design was employed, involving 2029 outpatients aged 15-50 years from the Shanghai Mental Health Center. BPD traits were assessed using the Personality Diagnostic Questionnaire 4th Edition Plus (PDQ-4+), and CM experiences were evaluated using the Child Trauma Questionnaire Short Form (CTQ-SF).