Publications by authors named "Yong Zhi Ng"
Article Synopsis
- The oral microbiota is the second largest microbial community in humans and plays a vital role in overall health, similar to gut microbiota, with interactions between these areas affecting our well-being.
- Recent studies indicate connections between oral diseases (like periodontitis) and gastrointestinal issues, revealing the importance of the oral-gut axis in systemic and neurological health.
- Diet significantly impacts microbial diversity in both the oral cavity and gut, where certain foods can enhance health while others may promote harmful bacteria, highlighting the need for dietary strategies to support the oral-gut-brain connection and combat age-related health issues.
Objective: The purpose of this study was to look into the associations between lifestyle factors, gender, clinical level, and sleep quality among undergraduate dental students at a private university in Malaysia.
Material And Methods: A self-administered Pittsburg sleep quality index (PSQI) scale and the lifestyle and habits questionnaire-brief (LHQ-B) were used in this cross-sectional study. A global PSQI score of greater than 5 indicates poor sleep quality.
While modulatory effects of gut microbes on neurological phenotypes have been reported, the mechanisms remain largely unknown. Here, we demonstrate that indole, a tryptophan metabolite produced by tryptophanase-expressing gut microbes, elicits neurogenic effects in the adult mouse hippocampus. Neurogenesis is reduced in germ-free (GF) mice and in GF mice monocolonized with a single-gene knockout (KO) mutant unable to produce indole.
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