Immunoadsorption therapy for Klinefelter syndrome with antiphospholipid syndrome in a patient: A case report.

Background: Klinefelter syndrome (KS) is a genetic disease of male sex chromosome malformations that affects sperm production and reduces testosterone production. It has been reported that there is currently more than 10 cases of KS combined with antiphospholipid syndrome.

Case Summary: Here, we describe a 31-year-old male patient with chromosome 47, XXY type, who suffered deep vein thrombosis of the lower limbs accompanied by abnormal antiphospholipid antibody, lupus anticoagulant and factor VIII.

Three new guaiane-type sesquiterpenoids and a monoterpenoid from Merr.

Three undescribed guaiane-type sesquiterpenes (), and a monoterpenoid () along with eleven known compounds () were isolated from the crude extract of Merr. The structures of all the isolated compounds were extensively elucidated on the basis of comprehensive spectroscopic techniques (HRESIMS, 1 D NMR, and 2 D NMR). Their relative and absolute configurations were comprehensively established by NOESY spectroscopy, circular dichroism (ECD) and the calculated ECD analysis.