Objective: We aimed to develop and validate a nomogram based on MRI radiomics to predict overall survival (OS) for patients with de novo oligometastatic prostate cancer (PCa).
Methods: A total of 165 patients with de novo oligometastatic PCa were included in the study (training cohort, n = 115; validating cohort, n = 50). Among them, MRI scans were conducted and T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) sequences were collected for radiomics features along with their clinicopathological features.
Purpose: To investigate the surgical effect of complete drainage of suprachoroidal fluid (SCF) before vitrectomy to avoid perioperative steroids in rhegmatogenous retinal detachment combined with choroidal detachment (RRD-CD) eyes.
Methods: It was a prospective, randomized controlled trial. 58 eyes were randomly divided into the no steroids (NS) group and local steroids (LS) group, 29 eyes each, respectively.
J Infect Dev Ctries
November 2024
Introduction: Mycobacterium marinum is a well-known pathogenic non-tuberculous mycobacterium for skin and soft tissue infections. Infection, often presenting as superficial lesions, is seen after exposure of skin abrasions to contaminated water or infected fish and is known as "swimming pool" or "fish tank" granuloma. This study reported a case of M.
View Article and Find Full Text PDFGlucosinolates' species and content serve as crucial indicators for Brassicaceae plants and their products. However, endogenous enzymes in Brassicaceae can hydrolyze glucosinolates, influencing their quantitative detection. Our study utilized rapeseed, a vital Brassicaceae oil crop, to establish a novel UHPLC-MS/MS method for glucosinolate determination, incorporating a pretreatment approach with enzyme inhibition.
View Article and Find Full Text PDFPacing Clin Electrophysiol
December 2024
Barbatula nuda is considered a promising emerging species to diversify small cold-water fish aquaculture worldwide due to its rapid growth and delicious flesh. However, limited information on larval development and nutrition is available. In this study, 7-day feeding experiments were performed to evaluate three different initial diets (zooplankton, phytoplankton, and artificial microdiet) in the zoo group, algae group, and AD group on growth, development, and digestion of larvae B.
View Article and Find Full Text PDFObjective: To build and validate a periprostatic fat magnetic resonance imaging (MRI) based radiomics nomogram for prediction of biochemical recurrence-free survival (bRFS) of patients with non-metastatic prostate cancer (PCa) receiving radical prostatectomy (RP).
Methods: A retrospective study was conducted on 356 patients with non-metastatic PCa who underwent preoperative mpMRI followed by RP treatment at our institution. Radiomic features were extracted from both intratumoral region and the periprostatic fat region, which were segmented on images obtained through T2-weighted imaging (T2WI) and apparent-diffusion coefficient (ADC) imaging.
Enhancing local field intensity through light field compression is one of the core issues in surface plasmon-enhanced spectroscopy. The theoretical framework for the nanostructure composed of a tip and a substrate has predominantly relied on classical electromagnetic models, ignoring the electron tunneling effect. In this paper, we investigate the plasmonic near-field characteristics in the sub-nanometer cavity formed by the tip and the substrate using a quantum-corrected model.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway plays a crucial role in transmembrane signal transduction, enabling cells to communicate with the extracellular environment, which requires precise regulation to prevent abnormal signaling outcomes. Within this complex pathway, suppressor of cytokine signaling 3 (SOCS3) acts as a pivotal negative regulator via binding to cytokine receptors. However, our understanding of the regulatory mechanisms governing SOCS3 interactions has been limited by the lack of suitable chemical probes.
View Article and Find Full Text PDFFiber strain and refractive index dual parameter sensor have enormous potential in the field of underwater structural health monitoring. This article proposes a strain and refractive index highly sensitive MZI-SPR composite sensor based on a dual fiber winding structure. By twisting single-mode fiber and multi-mode fiber, the two fibers are wound together to produce regular multiple bends.
View Article and Find Full Text PDFWhen the solar wind interacts with the ionosphere of an unmagnetized planet, it induces currents that form an induced magnetosphere. These currents and their associated magnetic fields play a pivotal role in controlling the movement of charged particles, which is essential for understanding the escape of planetary ions. Unlike the well-documented magnetospheric current systems, the ionospheric current systems driven by solar wind and atmospheric neutral winds have not been quantitatively observed, which constrains the quantification of energy transfer from stars to these planets.
View Article and Find Full Text PDFInt Immunopharmacol
December 2024
Although the nonmonotonic variation in the diffusion coefficients of alcohol and water with changing alcohol concentrations in aqueous solutions has been reported for many years, the underlying physical mechanisms remain unclear. Using molecular dynamics simulations, we investigated the molecular diffusion mechanisms in aqueous methanol solutions. Our findings reveal that the molecular diffusion is co-influenced by hydrogen bonding and the hydrophobic ends of methanol molecules.
View Article and Find Full Text PDFBackground: The elevation of IQGAP3 expression in diverse cancers indicates a key role for IQGAP3 in carcinogenesis. Although IQGAP3 was established as a proliferating stomach stem cell factor and a regulator of the RAS-ERK pathway, how it drives cancer growth remains unclear.
Objective: We define the function of IQGAP3 in gastric cancer (GC) development and progression.
Biochim Biophys Acta Mol Basis Dis
January 2025
Metabolic reprogramming precedes most alterations during pathological cardiac hypertrophy and heart failure (HF). Recent studies have revealed that Phosphofructokinase, platelet (PFKP) has a wealth of metabolic and non-metabolic functions. In this study, we explored the role of PFKP in cardiac hypertrophic growth and HF.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
The prognosis of patients diagnosed with locally advanced and metastatic gastric and esophago-gastric junction cancer is critical. The optimal choice of systemic therapy is essential to optimize survival outcomes. : A comprehensive literature review via PubMed and analysis of major oncology congresses (European Society for Medical Oncology and American Society of Clinical Oncology websites) were conducted to ascertain the current status and latest developments in the systemic treatment of patients with localized or advanced gastric and esophago-gastric junction adenocarcinoma.
View Article and Find Full Text PDFThe extensive use of scarce, expensive, and toxic elements in high-performance metal alloys restricts their sustainable development. Here we propose a novel alternative alloying-element design strategy that combines physicochemical-factor screening, a "black-box" interpretative method based on SHapley Additive exPlanation analysis, and sensitivity analyses of elemental influence. A "white-box" model of alloy compositions and properties is therefore established that enables the rational selection of abundant elements and the efficient designs of alloys with substitution for scarce alloying elements.
View Article and Find Full Text PDFWith high water cuts and high permeability reservoirs entering the middle and late stage, many old oil fields in China are facing the dilemma of oil and gas resource exhaustion, while low-permeability reservoir resources remain very rich. As an oil recovery technology, imbibition displacement plays an important role in the exploitation of low-permeability reservoirs and prolongs the production cycle of old oil fields. Based on the imbibition kinetic equation, the mechanism and process of oil displacement in imbibition recovery are explained in this paper.
View Article and Find Full Text PDFThe aim of this study was to investigate the differentially expressed genes associated with intramuscular fat deposition in the longissimus dorsi muscle of Xinjiang Brown Bulls. The longissimus dorsi muscles of 10 Xinjiang Brown Bulls were selected under the same feeding conditions. The intramuscular fat content of muscle samples was determined by the Soxhlet extraction method, for which 5 samples with high intramuscular fat content (HIMF group) and 5 samples with low intramuscular fat content (LIMF group) were selected.
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