Publications by authors named "Yong Su"

Background: In this study, we aimed to analyze the efficacy and failure patterns of contouring target volume based on the residual tumor and decreasing the dose to the area of tumor regression after neoadjuvant therapy in locoregionally advanced head and neck squamous cell carcinoma (HNSCC).

Methods: We retrospectively analyzed the patients with locoregionally advanced HNSCC treated by our group from May 2011 to June 2023. All patients received neoadjuvant therapy followed by intensity-modulated radiation therapy.

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Dissimilar welding between aluminum and copper poses significant challenges, primarily due to differences in their thermal and mechanical properties, resulting in brittle intermetallic compounds, limited joint strength, and high electrical resistivity. This study aims to overcome these issues by employing Ag-18Cu-10Zn filler material and optimizing laser power with a focus on improving joint strength and electrical conductivity. The results indicate that the incorporation of silver and zinc enhances the phase composition and microstructure of the weld.

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  • Time-restricted feeding (TRF) in pigs was tested to understand its effects on metabolic health compared to ad libitum feeding (ALF) with a focus on common eating habits.
  • All three TRF patterns (standard, early, and mid-day) resulted in less fat buildup in the liver and improved liver function markers, regardless of how much food was consumed.
  • The study found that TRF influenced liver gene expression and altered gut microbiota, particularly increasing Lactobacillus levels, which were linked to reduced serum triglycerides and improved lipid metabolism.
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  • Microstamping significantly boosts the surface strength of alloy materials, specifically TiAl6V4, by increasing interatomic density and improving mechanical properties at the atomic level.
  • The research includes a detailed examination of how different overlap ratios during microstamping affect the damage mechanism, dislocation density, and overall material structure, revealing that dislocation density remains stable despite higher overlap.
  • Through simulations using ATOMSK and LAMMPS, the study proposes an optimal microstamping overlay ratio to enhance surface strength while minimizing processing time based on a thorough analysis of stress variations and microstructural changes.
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extract (CME) contains many bioactive compounds, mainly cordycepin (CPN). This study aimed to investigate the possible mechanisms underlying the amelioration of LPS-induced acute liver injury in piglets by CME or CPN supplementation using multi-omics analysis. Twenty-four weaned piglets were randomly distributed into 4 groups ( = 6): the control and LPS groups were fed basal diets; the CPN + LPS (CPN-LPS) and CME + LPS (CME-LPS) groups were fed the basal diets supplemented with CME or CPN.

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Objectives: Fructo-oligosaccharide (FOS) and citrus pectin (CP) are soluble fibers with different chemical composition. However, their fermentation pattern in the large intestine remains unclear.

Methods: An in vitro batch fermentation using colonic digesta from pigs as inoculum was employed to investigate the fermentation dynamics of FOS and CP.

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L. capitulum is an enriched source of flavonoids with broad-ranging biological activities, mainly due to their anti-inflammatory, anti-cancer, immune regulation, anti-microbial activity, hepatoprotective, and neuroprotective effects. The -methylation of various secondary metabolites has previously been demonstrated to be mainly catalyzed by -adenosyl-L-methionine-dependent -methyltransferase (OMT) proteins encoded by the gene family.

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Aims: Hydroxychloroquine (HCQ) is recommended for the long-term treatment of rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus. Given the complex process of HCQ metabolism and individual physiological differences, the metabolic profile of HCQ after long-term administration is unknown. This study aimed to establish a population pharmacokinetic model for long-term HCQ treatment in patients with rheumatic diseases and to identify the factors influencing HCQ metabolism.

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  • Sarcopenia is a disease characterized by the gradual loss of skeletal muscle mass and function due to factors like aging, malnutrition, and cardiovascular issues.
  • Exercise and proper nutrition are effective strategies to combat sarcopenia by enhancing muscle growth and health.
  • The review examines recent research on how these strategies work at a biological level, including their effects on blood flow, inflammation, and protein metabolism, aiming to improve prevention and treatment options for sarcopenia.
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Introduction: Si-Ni-San (SNS), a traditional Chinese medicine, is effective in treating liver fibrosis with an unclear mechanism. Although disturbance of intestinal flora and the subsequent secretion of short-chain fatty acids (SCFAs) is suggested to be involved in the progression of liver fibrosis, whether SNS produces the anti-fibrosis effect through the regulation of intestinal flora and SCFAs remains unclear.

Methods: In the current study, carbon tetrachloride (CCl)-treated mice were dosed with SNS to examine the anti-fibrotic effects and the involved mechanism.

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In order to address the increasingly prominent issues of water resource protection and agricultural non-point source pollution in the Erhai Lake Basin, this study conducted a two-year field experiment in Gusheng Village, located in the Erhai Lake Basin. In 2022, two irrigation treatments were set up: conventional flooding irrigation (CK) and controlled irrigation (C), with three replicates for each treatment. In 2023, aiming to enhance the utilization rate of rainwater resources and reduce the direct discharge of dry-farming tailwater from upstream into Erhai Lake.

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  • Nasopharyngeal carcinoma (NPC) is a challenging cancer to detect early due to its high metastatic potential, prompting a study to create a deep learning model for diagnosis using optical imagery.
  • The researchers analyzed over 12,000 endoscopic images and 300 videos from patients, enhancing a pretrained model with advanced training techniques and evaluating its performance through metrics like AUC and accuracy.
  • The deep learning model showed excellent accuracy in identifying NPC, achieving AUC values of up to 0.981, indicating its potential for effective and early diagnosis of this cancer across different datasets.
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Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by memory impairment and cognitive dysfunction, which eventually leads to the disability and mortality of older adults. Although the precise mechanisms by which age promotes the development of AD remains poorly understood, mitochondrial dysfunction plays a central role in the development of AD. Currently, there is no effective treatment for this debilitating disease.

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Cirrhosis impairs macrophage function and disrupts bile acid homeostasis. Although bile acids affect macrophage function in patients with sepsis, whether and how the bile acid profile is changed by infection in patients with cirrhosis to modulate macrophage function remains unclear. The present study aimed to investigate the changes in the bile acid profile of patients with cirrhosis and infection and their effects on macrophage function.

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Antibiotic-induced gut dysbiosis (AID) presents a big challenge to host health, and the recovery from this dysbiosis is often slow and incomplete. AID is typically characterized by elevation in redox potential, Enterobacteriaceae load, and aerobic metabolism. In our previous study, a pectin-enriched diet was demonstrated to decrease fecal redox potential and modulate the gut microbiome.

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Objective: This retrospective study analyzed the efficacy of PD-1 inhibitors combined with albumin-bound paclitaxel and cisplatin (TP regimen) in the treatment of recurrent and metastatic hypopharyngeal/laryngeal squamous cell carcinoma (RMHSCC/RMLSCC).

Methods: Patients diagnosed and treated at the Sun Yat-sen University Cancer Center from August 1, 2020, to August 15, 2023, with histologically confirmed RMHSCC/RMLSCC were included. All patients received PD-1 inhibitors combined with albumin-bound paclitaxel (260mg/m2) and cisplatin (60mg/m2) for 3-4 cycles.

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Real-world data on the range and impact of comorbid health conditions that affect pediatric asthma are scant, especially from developing countries. Lack of data hinders effective diagnosis, treatment, and overall management of these complex cases. We, hereby, describe the common pediatric asthma comorbid conditions in terms of evidence for association, potential mechanisms of impact on asthma control, and treatment benefit.

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This study investigates the nexus between rising temperatures and household energy consumption using data from respondents' electricity bills in the "China Residential Energy Consumption Survey." Our analysis reveals a significant correlation, with an 8.9 % increase in yearly energy consumption observed when the average temperature exceeds 32 °C.

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Alzheimer's disease (AD) is a progressive neurodegenerative disease. Neuronal calcium overload plays an important role in Aβ deposition and neuroinflammation, which are strongly associated with AD. However, the specific mechanisms by which calcium overload contributes to neuroinflammation and AD and the relationship between them have not been elucidated.

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Cordycepin is considered a major bioactive component in extract. This study was performed to evaluate the ameliorative effect of extract (CME) and cordycepin (CPN) supplementation on intestinal damage in LPS-challenged piglets. The results showed that CPN or CME supplementation significantly increased the villus height ( < 0.

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Various studies have focused on the application of fibrin sealants (FS) in thyroid surgery. Utilizing a meta-analysis, this systematic review analyzed the findings of recent randomized controlled trials on the safety and efficacy of FS in patients who underwent thyroidectomy. The Cochrane Library, Web of Science, Embase, PubMed, and Medline databases were searched for relevant studies, without any language restrictions.

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  • The study aimed to compare the effectiveness and toxicity of platinum-based adjuvant chemoradiotherapy (POCRT) versus postoperative radiotherapy (PORT) in patients with head and neck adenoid cystic carcinoma (HNACC).
  • A total of 206 patients were analyzed, with the results showing that the POCRT group had better local-regional control (LRC) rates than the PORT group and identified concurrent chemotherapy as a significant factor influencing LRC.
  • Although POCRT was more effective in preventing local-regional failures, it also resulted in increased treatment-related toxicities, such as upper gastrointestinal and hematologic issues, including leukopenia and anemia.
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Background: Graves' disease (GD), characterized by immune aberration, is associated with gut dysbiosis. Despite the growing interest, substantial evidence detailing the precise impact of gut microbiota on GD's autoimmune processes remains exceedingly rare.

Objective: This study was designed to investigate the influence of gut microbiota on immune dysregulation in GD.

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Background: Vitamin C has significant anti-inflammatory effects and is particularly important for critically ill patients. However due to inconsistent research findings in critically ill patients in meta-analysis. Therefore, the primary objective of this meta-analysis is to investigate the effects of isolated intravenous supplementation of vitamin C in adults with critical illness by comprehensively incorporating articles from randomized controlled trials.

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