Photochemical Transformation of Ibuprofen and Chlorophene Induced by Dissolved Organic Matter.

Both ibuprofen (IBP) and chlorophene (CP) are frequently detected contaminants in surface aqueous environment. Dissolved organic matter (DOM) is an important component in water with high photo-reactivity, playing an important role in the transformation processes of various organic pollutants. This study systematically studied the influence of DOM on the photochemical transformation of IBP and CP by using humic acid as model DOM.

A Personal Healthcare Knowledge Graph Framework for Diagnosis of Pelvic Masses Diseases.

A Personal Health Knowledge Graph (PHKG) facilitates the efficient integration of potential diagnostic clues from patients' electronic health records with medical knowledge, establishing diagnostic reasoning paths and ensuring accurate, individually interpretable results in the diagnosis of pelvic masses.

A few-shot disease diagnosis decision making model based on meta-learning for general practice.

Background: Diagnostic errors have become the biggest threat to the safety of patients in primary health care. General practitioners, as the "gatekeepers" of primary health care, have a responsibility to accurately diagnose patients. However, many general practitioners have insufficient knowledge and clinical experience in some diseases.

Multi-band spatial feature extraction and classification for motor imaging EEG signals based on OSFBCSP-GAO-SVM model : EEG signal processing.

Electroencephalogram (EEG) is a non-stationary random signal with strong background noise, which makes its feature extraction difficult and recognition rate low. This paper presents a feature extraction and classification model of motor imagery EEG signals based on wavelet threshold denoising. Firstly, this paper uses the improved wavelet threshold algorithm to obtain the denoised EEG signal, divides all EEG channel data into multiple partially overlapping frequency bands, and uses the common spatial pattern (CSP) method to construct multiple spatial filters to extract the characteristics of EEG signals.

Causal knowledge graph construction and evaluation for clinical decision support of diabetic nephropathy.

Background: Many important clinical decisions require causal knowledge (CK) to take action. Although many causal knowledge bases for medicine have been constructed, a comprehensive evaluation based on real-world data and methods for handling potential knowledge noise are still lacking.

Objective: The objectives of our study are threefold: (1) propose a framework for the construction of a large-scale and high-quality causal knowledge graph (CKG); (2) design the methods for knowledge noise reduction to improve the quality of the CKG; (3) evaluate the knowledge completeness and accuracy of the CKG using real-world data.

EHR-Oriented Knowledge Graph System: Toward Efficient Utilization of Non-Used Information Buried in Routine Clinical Practice.

Non-used clinical information has negative implications on healthcare quality. Clinicians pay priority attention to clinical information relevant to their specialties during routine clinical practices but may be insensitive or less concerned about information showing disease risks beyond their specialties, resulting in delayed and missed diagnoses or improper management. In this study, we introduced an electronic health record (EHR)-oriented knowledge graph system to efficiently utilize non-used information buried in EHRs.

Diversity-oriented functionalization of 2-pyridones and uracils.

Heterocycles 2-pyridone and uracil are privileged pharmacophores. Diversity-oriented synthesis of their derivatives is in urgent need in medicinal chemistry. Herein, we report a palladium/norbornene cooperative catalysis enabled dual-functionalization of iodinated 2-pyridones and uracils.

Improved purified terephthalic acid wastewater treatment using combined UAFB-SBR system: At mesophilic and ambient temperature.

In this study, a combined UAFB-SBR process was introduced to improve the treatment efficiency of PTA wastewater. The techno-economic feasibility of the process was evaluated in terms of organic removal efficiencies under mesophilic (37 °C) and ambient temperature (15-25 °C) during the long-term run. The lab-scale study revealed that all organic compounds present in the PTA wastewater could be efficiently removed under both mesophilic and ambient temperature, and p-toluic acid is probably the critical pollutant regulating the overall process performance in anaerobic stage, which should be seriously considered.

Effective extraction of fluorescent brightener 52 from foods by in situ formation of hydrophobic deep eutectic solvent.

Fluorescent brightener 52 (FWA52) is a coumarin-based compound, and it is difficult to degrade owing to its high chemical stability. Up to now, several methods have been developed to extract and determine FWAs, but toxic, volatile and harmful organic solvents are often used. In this paper, a novel method for the extraction and analysis of FWA52 is proposed for the first time by in situ formation of hydrophobic deep eutectic solvent (DES) with parabens in aqueous solution.

Synthesis of Benzofused Dioxabicycle Scaffolds via a Catellani Strategy.

Reported is a modular strategy for the preparation of the unique benzofused dioxabicycle scaffolds involving a Catellani reaction of aryl iodides, epoxides, and terminal alkynes and an -cyclization. This is a mild, scalable, chemoselective, and atom-economical protocol, compatible with various functionalized aryl iodides, epoxides, and terminal alkynes. With the ability to build up the molecular complexity rapidly and efficiently from feedstock chemicals, this method will have wide applications in organic synthesis.

Modular Dual-Tasked C-H Methylation via the Catellani Strategy.

We report a dual-tasked methylation that is based on cooperative palladium/norbornene catalysis. Readily available (hetero)aryl halides (39 iodides and 4 bromides) and inexpensive MeOTs or trimethylphosphate are utilized as the substrates and methylating reagent, respectively. Six types of "ipso" terminations can modularly couple with this "ortho" C-H methylation to constitute a versatile methylation toolbox for preparing diversified methylated arenes.

A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids.

Steroidal C19-hydroxylation is pivotal to the synthesis of naturally occurring bioactive C19-OH steroids and 19-norsteroidal pharmaceuticals. However, realizing this transformation is proved to be challenging through either chemical or biological synthesis. Herein, we report a highly efficient method to synthesize 19-OH-cortexolone in 80% efficiency at the multi-gram scale.

Analysis of the depression and anxiety status and related risk factors in patients with lumbar disc herniation.

Objectives: To evaluate the depression and anxiety status and related risk factors in patients with lumbar disc herniation, and help spine surgeons better identify those patients who need psychological care.

Methods: A cross-sectional study was performed on patients with lumbar disc herniation treated in our hospital between October 2015 and August 2018. Visual analog scale and Oswestry disability index were used to assess pain intensity and lumbar function, and Zung self-rating depression and anxiety scale were employed to evaluate the depression and anxiety status of the patients, and the demographic and clinical data including age, gender, marital status, occupation type, employment status, education level, surgery history, herniation type, disease duration, and insurance status were collected for analysis.

Pyrolysis of blend (oil palm biomass and sawdust) biomass using TG-MS.

The aim of this study was to pyrolyze individual (oil palm shell, empty fruit bunch and sawdust) as well as blend biomass in a thermogravimetric mass spectrometry (TG-MS) from room temperature to 800 °C at constant heating rate of 15 °C/min. The results showed that the onset TG temperature for blend biomass shifted slightly to lower values. Activation energy values were also found to decrease slightly after blending the biomass.

Comparison of two types of exercises in the treatment of lumbar spinal stenosis.

Objective: To evaluate the efficacy of core stability exercise versus conventional exercise in the treatment of lumbar spinal stenosis.

Methods: Between January 2014 and May 2017, patients with lumbar spinal stenosis were recruited and divided into group of core stability exercise or conventional exercise randomly. All the patients were treated using middle frequency electrotherapy, in addition to that, the patients in group of core stability exercise were treated using core stability exercise.

POPCORN: A web service for individual PrognOsis prediction based on multi-center clinical data CollabORatioN without patient-level data sharing.

Background And Objective: Clinical prognosis prediction plays an important role in clinical research and practice. The construction of prediction models based on electronic health record data has recently become a research focus. Due to the lack of external validation, prediction models based on single-center, hospital-specific datasets may not perform well with datasets from other medical institutions.

CD-KES: An Ontology Based Knowledge Education System for Patients with Chronic Diseases and Its Constructing Approach.

Patients' participation plays a crucial role in the management of chronic diseases. Educating patients about their diseases allows patients to self-regulate their daily health conditions more reasonably and effectively. This study focuses on an informative way to develop daily education and guidance among patients.

Development of a Service-Oriented Sharable Clinical Decision Support System Based on Ontology for Chronic Disease.

Clinical decision support systems (CDSSs) have been proved as an efficient way to improve health care quality. However, the inflexibility in integrating multiple clinical practice guidelines (multi-CPGs), the mass input workload of patient data, and the difficulty in system sharing become barriers of CDSSs implementation. In this paper, we proposed a framework of CDSS for chronic disease based on ontology and service-oriented architecture (SOA) to improve these defects.

Wnt/β-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase.

Objectives: Our goal was to investigate the relationship between keloid and telomerase as well as clarifying the influence of Wnt/β-catenin signaling on keloid cell proliferation.

Methods: Tissues from 18 keloid patients were collected for further study. Keloid progenitor cells (KPC) and skin progenitor cells (SKP) were both included in this study.

Scarless Epicanthoplasty and Concomitant Double Eyelidplasty in Chinese Eyelids.

Background: The presence of mild or moderate medial epicanthus is typical in Asian patients. Numerous epicanthoplasty techniques have been described previously. However, these methods usually leave obvious scars in the medial canthal area.

MicroRNA-196a overexpression promotes cell proliferation and inhibits cell apoptosis through PTEN/Akt/FOXO1 pathway.

MicroRNAs (miRNAs) are endogenous, non-coding, small RNAs, which play a critical role in regulating varieties of the biological and pathologic processes. MiR-196a has been reported to take part in tumorigenic progression of osteosarcoma (OS). However, the effects of miR-196a on OS are still unclear.

Liposome-Adenoviral hTERT-siRNA Knockdown in Fibroblasts from Keloids Reduce Telomere Length and Fibroblast Growth.

Keloids, which possess invasive tumor-like behavior, have been clinically challenging to clinicians especially surgeons. Excessive extracellular matrix secreted from fibroblasts is the main histo-pathological feature of keloids. In this study, we transfected hTERT-siRNA into scar fibroblasts by liposome-adenoviral transduction in order to disrupt telomere length homeostasis and influence the cell cycle of fibroblasts.

Association of ADAM33 gene polymorphisms with keloid scars in a northeastern Chinese population.

Objective: To study the association between ADAM33 and keloid scars in the northeastern Chinese population.

Methods: A total of 283 keloid scar patients and a control group of 290 healthy volunteers were recruited for this study. Six polymorphic loci (V4, T+1, T2, T1, S2 and Q-1 ) of ADAM33 were selected for genotyping.