Effect of canine cortical bone demineralization on osteogenic differentiation of adipose-derived mesenchymal stromal cells.

Demineralized bone allografts and mesenchymal stromal cells have been used to promote bone regeneration. However, the degree to which cortical bone should be demineralized for use in combination with adipose-derived mesenchymal stromal cells (Ad-MSCs) remains to be clarified. In this study, the osteogenic ability of Ad-MSCs on allografts was investigated in relation to the extent of demineralization.