Effective Multi-Object Tracking via Global Object Models and Object Constraint Learning.

Effective multi-object tracking is still challenging due to the trade-off between tracking accuracy and speed. Because the recent multi-object tracking (MOT) methods leverage object appearance and motion models so as to associate detections between consecutive frames, the key for effective multi-object tracking is to reduce the computational complexity of learning both models. To this end, this work proposes global appearance and motion models to discriminate multiple objects instead of learning local object-specific models.

Design, synthesis, and antiangiogenic effects of a series of potent novel fumagillin analogues.

A series of fumagillin analogues containing the C6-substituted cinnamoyl moiety were designed, synthesized, and evaluated for antiangiogenic activity. Among them, 4-hydroxyethoxy-cinnamoyl fumagillol (4a) and 4-hydroxyethoxy-3,5-dimethoxycinnamoyl fumagillol (4d) exhibited more potent anti-proliferation activity in CPAE and HUVEC cells with low cytotoxicity in vitro. These compounds are presently under further pharmacological evaluation studies.