One-Step Hybrid Bending/Diffusion Bonding Process and Analysis of the Bonding Characteristics of Titanium Alloy Sheets.

A one-step hybrid bending/diffusion bonding process (HB/DBP) was developed for application to Ti-6Al-4V sheets to effectively improve buy-to-fly (BTF) ratio of aircraft parts, integrating sequential diffusion bonding followed by a bending process. The resulting bonding characteristics of these titanium alloy sheets were analyzed. Microstructural analysis and mechanical lap shear tests were performed to estimate the bonding quality.

health monitoring of multiscale structures and its instantaneous verification using mechanoluminescence and dual machine learning.

Extensive changes in the legal, commercial and technical requirements in engineering fields have necessitated automated real-time structural health monitoring (SHM) and instantaneous verification. An integrated system with mechanoluminescence (ML) and dual artificial intelligence (AI) modules with subsidiary finite element method (FEM) simulation is designed for SHM and instantaneous verification. The ML module detects the exact position of a crack tip and evaluates the significance of existing cracks with a plastic stress-intensity factor (PSIF; ).

Synthetic Coprisin analog peptide, D-CopA3 has antimicrobial activity and pro-apoptotic effects in human leukemia cells.

Recently, we reported that the synthetic Coprisin analog peptide 9-mer dimer CopA3 (consisted of all-L amino acid sequence) was designed based on a defensin-like peptide, Coprisin isolated from Copris tripartitus. The 9-mer dimer CopA3 (L-CopA3) had antibacterial activity and induced apoptosis in human leukemia cells via a caspase-independent pathway. In this study, all of amino acid sequences of L-CopA3 were modified to all D-form amino acids (D-CopA3) to develop a more effective antimicrobial peptide.

Effects of the synthetic coprisin analog peptide, CopA3 in pathogenic microorganisms and mammalian cancer cells.

A synthetic coprisin analog peptide, 9-mer dimer CopA3 (CopA3) was designed based on a defensin-like peptide, Coprisin, isolated from the bacteria-immunized dung beetle Copris tripartitus. Here, CopA3 was investigated for its antimicrobial activity and cancer cell growth inhibition. CopA3 showed antimicrobial activities against various pathogenic bacteria and yeast fungus with MIC values in 2~32 μM ranges, and inhibited the cell viabilities of pancreatic and hepatocellular cancer cells, except MIAPaca2, Hep3B, and HepG2 cells, in a dose-dependent manner.

Rate-equation model for the loading-rate-dependent mechanoluminescence of SrAl2O4:Eu2+,Dy3+.

The mechanoluminescence (ML) of SrAl2O4:Eu2+,Dy3+ (SAO) phosphors was monitored as a function of its instantaneous loading rate, on which it was found to be strongly dependent. The effect of the loading rate on the ML of SAO was investigated in a systematic manner using rate equations involving the loading rate term. The rate equations and the experimental data matched well.