Publications by authors named "Yong Mei Tang"
Article Synopsis
- * The study reveals that a selective PI3Kδ inhibitor, TYM-3-98, can initiate ferroptosis (a type of non-apoptotic cell death) in KRAS-mutant CRC cells by disrupting key signaling pathways and enhancing lipid peroxidation.
- * In experiments with mouse models, TYM-3-98 effectively reduced tumor growth without causing significant liver or kidney toxicity, highlighting its potential as a novel therapeutic option for CRC.
Article Synopsis
- The researchers studied a protein called PI3Kδ, which is linked to cancers in white blood cells, and discovered that current medicines targeting it can have harmful side effects.
- They created a new drug called TYM-3-98 that specifically targets the PI3Kδ protein and works better than an older drug in fighting certain types of blood cancer.
- TYM-3-98 was shown to stop cancer cells from growing and helped shrink tumors in tests done on mice and human cancer cells.
Background: Cryogenic freezing, often known as cryopreservation, is a technique for preserving human oocytes.
Methods: In this study, differentially expressed long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) were identified using the human frozen oocyte dataset GSE69768 from the Gene Expression Database (GEO). Subsequently, combined with the microRNA atlas database, the miRNAs combined with differentially expressed lncRNAs (DElncRNAs) were predicted, and the lncRNA-miRNA-mRNA interaction relationship and competitive endogenous (ceRNA) regulatory network were obtained.
Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors.
Bioorg Med Chem Lett
October 2018
A series of 3,5-dimethylpyrazole derivatives containing 5-phenyl-2-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. Bioassay results showed that the title compounds exhibited considerable inhibitory activity against PDE4B and blockade of LPS-induced TNFα release. Among the designed compounds, compound If showed the best inhibitory activity against PDE4B with the IC value of 1.
View Article and Find Full Text PDFWe aimed to examine the effect of micronutrient losses through sweat on blood pressure (BP) among heat-exposed steelworkers. A total of 224 heat-exposed male steelworkers from an ironworks facility were evaluated in July 2012. We measured the Wet Bulb Globe Temperature Index to evaluate the level of heat stress in the workplace.
View Article and Find Full Text PDFObjective: To retrospectively study the clinical effects of eardrum flap area on the healing outcome following traumatic perforation.
Methods: Totally 291 traumatic eardrum perforations with in-/everted edges were included in this study. They were randomly divided into three groups and received conservative treatment, epidermal growth factor (EGF) via Gelfoam patching, or edge-approximation plus Gelfoam patching respectively.
Prognosis and outcome of the tympanic membrane flap at traumatic tympanic membrane perforation edge.
ORL J Otorhinolaryngol Relat Spec
December 2011
This study aimed to retrospectively evaluate the prognosis and outcome of tympanic membrane perforations with a particular focus on the fate of the perforation edge flaps.Chart records of 329 patients with a single ear traumatic tympanic membrane perforation were retrieved and analyzed. Of these patients, 70 were left to heal spontaneously, 93 received gelatin sponge patching treatment and 114 were subjected to otoendoscopic eardrum repair before gelatin sponge patching.
View Article and Find Full Text PDFConclusion: Treatment of traumatic tympanic membrane (TM) perforation with everted or involute edge flaps at different time intervals within 1 week after the injury did not affect the perforation closure rate and mean closure time.
Objective: To retrospectively analyze the effect of treatment at different time intervals for traumatic tympanic membrane perforation with gelatin sponge patch and edge approximation plus gelfoam patching.
Methods: Patients with traumatic TM perforation visited at different days since the injury for medical treatment (1, 2, 3, 4, and 5-7 days post trauma).
Objective: To review the changes in immune function and incidence of infectious diseases in pregnant women with iron deficiency anemia (IDA), especially marginalde-ficiency of iron.
Methods: T lymphocyte subsets level (CD3+, CD4+ and CD8+), nature kill cells activity (CD16), interleukin-2 (IL-2) and serum IgA, IgG, IgM and complement C3 were determined in 3 different wormen groups, including 69 IDA pregnant women who were diagnosed by Hemoglobin, concentrations of free erythocyte porphrin and serum ferritin from 280 pregnant women during 30-38weeka of gestation, 52 random sampling normal pregnant women and 50 no pregnant women examined before marriage.
Results: The prevalenoe of IDA for pregnant women is 24.
[Study on genetic instability of NM23H1 gene in Chinese with the epithelial ovarian tumor].
Shi Yan Sheng Wu Xue Bao
June 2005
Article Synopsis
- The study investigated the relationship between microsatellite instability (MSI) and loss of heterozygosity (LOH) at the D17S396 locus on chromosome 17 and their impact on the nm23H1 gene in epithelial ovarian tumors to understand tumor metastasis mechanisms.
- Techniques like PCR-SSCP and immunohistochemistry were employed, revealing a 40% heredity instability rate in malignant tumors and a significantly higher LOH frequency in metastasized cases compared to non-metastasized.
- Results indicated that nm23H1 expression was lower in later FIGO stages and lymph node metastasis cases, emphasizing its potential role in tumor progression and metastasis.