Publications by authors named "Yong M"

The global transition to clean energy technologies has escalated the demand for lithium (Li), a critical component in rechargeable Li-ion batteries, highlighting the urgent need for efficient and sustainable Li extraction methods. Nanofiltration (NF)-based separations have emerged as a promising solution, offering selective separation capabilities that could advance resource extraction and recovery. However, an NF-based lithium extraction process differs significantly from conventional water treatment, necessitating a paradigm shift in membrane materials design, performance evaluation metrics, and process optimization.

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Objectives: We aimed to describe the characteristics of Clostridioides difficile infection (CDI) in cancer patients, analysing risk factors for 90-day recurrence and attributable mortality.

Methods: Retrospective analysis on all CDI episodes from 2020 to 2022 in three Australian hospitals and one Spanish hospital. Logistic regression analyses were performed.

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Objective: To analyze the accuracy of ChatGPT-generated responses to common rhinologic patient questions.

Methods: Ten common questions from rhinology patients were compiled by a panel of 4 rhinology fellowship-trained surgeons based on clinical patient experience. This panel (Panel 1) developed consensus "expert" responses to each question.

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Cytomegalovirus (CMV) infections continue to be associated with significant morbidity and mortality following solid organ transplantation and haemopoietic stem cell transplantation. Advances in understanding the biology of CMV in the immunosuppressed host will translate into improved management approaches and better clinical outcomes. Updated definitions of resistant and refractory CMV infections will lead to more consistent reporting of CMV outcomes, better inform appropriate antiviral strategies and influence clinical trial design.

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  • The study aimed to investigate the potential of differentially expressed long non-coding RNAs (lncRNAs) in human peripheral blood mononuclear cells as biomarkers for postmenopausal osteoporosis (PMOP), comparing samples from PMOP patients and postmenopausal patients without osteoporosis.
  • RNA sequencing revealed 1978 differentially expressed lncRNAs and 1024 mRNAs, with bioinformatics analysis showing these genes were primarily involved in pathways related to protein binding and key signaling pathways like PI3K-Akt.
  • Further correlation analysis highlighted specific lncRNAs, such as RAB37, BEGAIN, and ZNF529, as potential diagnostic markers for PMOP based on their interaction with mRNAs
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Background: Antimicrobial stewardship (AMS) guidelines now recommend antifungal stewardship (AFS) interventions to improve the management of invasive fungal diseases (IFDs). AFS programmes have not been reported in Australia.

Aims: To determine the monitoring of antifungal use, AFS strategies and targets, and barriers to AFS implementation in Australian hospitals.

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Objective: More than 130 susceptibility loci for rheumatoid arthritis (RA) have been identified with genome-wide association studies. To investigate the genetic predisposition of Chinese patients to anticitrullinated protein antibody (ACPA)-positive RA, we carried out an exome sequencing study.

Methods: Patients were recruited from 3 major public hospitals in Singapore: Tan Tock Seng Hospital (TTSH), Singapore General Hospital, and the National University Hospital.

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  • The research utilized techniques like SDS-PAGE and LCMS/MS to investigate venom protein variability and identified conserved protein families with diverse expressions that do not follow snake evolutionary lineages.
  • Key findings indicate that while certain enzymes' expression correlates weakly with venom effects, phospholipase A activity strongly correlates with its abundance, and a small molecule inhibitor, varespladib, may effectively inhibit PLA activities, suggesting its potential as a therapeutic for snakebite treatment.
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To explore the factors influencing the clinical pregnancy rate in the Reproductive Center of the Affiliated Hospital of North Sichuan Medical College in the second cycle, a retrospective analysis of the clinical data of 175 patients who underwent the second cycle of intrauterine insemination (175 cycles) from July 2019 to July 2022 was performed. According to whether the patients reached clinical pregnancy, they were divided into the pregnant group (32 cycles) and non-pregnant group (143 cycles). The age, infertility years, infertility factors, infertility type, number of sinus follicles, intimal thickness, intimal type, basal follicle-stimulating hormone, basal luteinizing hormone, basal estradiol, stimulation regimen, season, body mass index, and male semen quality were statistically analyzed between the 2 groups.

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Significance: Acute macular neuroretinopathy (AMN) is a rare disease that causes transient or permanent visual disturbance. The exact etiology remains unknown, but vascular compromise of the deep retinal capillary plexus was postulated as the main mechanism. Retinal vascular event post-coronavirus disease 2019 (COVID-19) infection is recently highlighted during the pandemic, which includes AMN.

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Background: International consensus definitions for invasive aspergillosis (IA) in research are rigorous, yet clinically significant cases are often excluded from clinical studies for not meeting proven/probable IA case definitions. To better understand reasons for the failure to meet criteria for proven/probable infection, we herein review 47 such cases for their clinical and microbiological characteristics and outcomes.

Methods: Data on 47 cases that did not meet consensus IA definitions but were deemed significant were derived from a retrospective, observational, multicenter survey of 382 presumed IA cases across Australasia, of which findings of 221 proven/probable infections were recently published.

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Abnormal autophagy and the transforming growth factor-β (TGFβ)-SMAD3/7 signaling pathway play an important role in the development of intrauterine adhesions (IUAs); however, the exact underlying mechanisms remain unclear. In this study, we used IUA patient tissue and SMAD7 conditional knockout mice to detect whether SMAD7 effected IUA via regulation of autophagy and the TGFβ-SMAD3 signaling pathway. We applied a combination of techniques for the detection of p-SMAD3, SMAD7, autophagy and fibrosis-related proteins, autophagic flux, and analysis of the SMAD3 binding site.

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Aim: This study aimed to examine contemporary burden and treatment trends of atrial fibrillation (AF) in patients undergoing cardiac surgery in Australia and New Zealand. This allows comparison of contemporary practice with the Society of Thoracic Surgeons guideline recommendations for the surgical treatment of AF in patients undergoing cardiac surgery.

Method: A 10-year retrospective review of the Australian & New Zealand Society of Cardiac & Thoracic Surgeons National Cardiac Surgery Database was performed, examining all adult cardiac surgery patients from 2011 to 2021.

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  • Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer, and while a resection margin of at least 4 mm is standard, this study investigated the outcomes of a smaller 3-mm margin.
  • The study looked at 205 patients with primary BCC tumors less than 2 cm, and found recurrence rates at 1.95% and re-resection rates at 25.85%, with significant factors including tumor border, location, and patient immunosuppression.
  • Results suggest that a 3-mm margin can be effective for small facial BCCs, but it's crucial to individually assess patients, especially those in high-risk categories needing larger margins for better outcomes.
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Purpose Of Review: Cytomegalovirus (CMV) infection is associated with severe clinical disease and high morbidity in immunocompromised hosts. Letermovir and maribavir, are two recently developed antiviral drugs used in the prevention and treatment of resistant and refractory CMV. Following the publication of landmark randomized trials and increased use, both clinical trial data and real-world experience has reported the development of antiviral drug resistance.

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  • The thickening of radish taproots is mainly influenced by secondary growth involving the vascular cambium, regulated by hormones like gibberellin (GA) and other metabolic pathways, although the exact mechanism of GA3's role is unclear.
  • Research using morphological, anatomical, hormonal, and transcriptomic analyses showed that GA3 inhibits taproot thickening, while its inhibitor paclobutrazol (PBZ) enhances root length without increasing diameter.
  • Transcriptome analysis revealed significant gene expression changes related to hormone signaling and vascular cambium differentiation, suggesting that GA3 regulates root thickening through complex hormonal interactions and metabolic processes.
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Background And Aims: CircRNAs and autophagy are closely involved in the physiological and pathological processes of ovarian cancer; however, their exact mechanisms are still undetermined. This investigation aimed to elucidate the function and associated pathways of circFAM188A, which modulates proliferation, autophagy, and invasion in ovarian cancer (EOC).

Methods: The expression of circFAM188A in the tissues of EOC patients was assessed via RT-PCR.

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This paper investigates the structure and aggregation stability of acrylic acid-acrylamide-diethyldiallylammonium chloride (FA367), followed by an investigation into the impact of acidic CO environments on the interaction between FA367 and cement slurry. The results showed that FA367 formed stable flocculation in cement slurry filtrate, which was not affected by acid gas CO. With an FA367 concentration of 0.

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Introduction: is important vegetables and seasonings in China, Tibet is rich in unique resources of the genus , but lacks development and utilization.

Methods: We compared the biological features and comprehensively evaluating the quality of twelve germplasm resources of the genus collected from Tibet.

Results: The results revealed that nine germplasm resources were bolting and bloom normally except for SC015, SC019, and SC048, all twelve germplasm resources were able to vegetative growth.

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  • Accidental ingestions of food allergens remain a significant issue despite known allergies, with surveys showing rates of 10% to 25% of participants reporting incidents each month.
  • Key triggers for these accidental ingestions include milk, wheat, and tree nuts, with the retrospective data indicating milk as the most common offender.
  • The occurrence of severe reactions, such as anaphylaxis, was notably high in both surveyed and retrospective cohorts, highlighting the need for continuous education on allergen avoidance.*
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  • Acute hemorrhagic leukoencephalitis (AHLE) is a rare and serious form of ADEM with varying outcomes, often related to infections, particularly COVID-19.
  • A systematic review identified 31 previous cases, revealing that a significant portion was preceded by infections, and alterations in mental status and GCS scores were linked to severe outcomes.
  • The study suggests that certain clinical presentations, such as altered mental status and an abnormal upgoing plantar response, could indicate poor prognoses in AHLE cases, highlighting the need for further research.
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Background: Food specific immunoglobulin E (sIgE) levels are associated with the development of allergic responses and are used in the clinical evaluation of food allergy. Food sIgG4 levels have been associated with tolerance or clinical nonresponsiveness, particularly in interventional studies.

Objective: We aimed to characterize food-specific antibody responses and compare responses with different foods in food allergy.

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It is self-evident that our chests expand and contract during breathing but, surprisingly, exactly how individual alveoli change shape over the respiratory cycle is still a matter of debate. Some argue that all the alveoli expand and contract rhythmically. Others claim that the lung volume change is due to groups of alveoli collapsing and reopening during ventilation.

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