Regulatory considerations for paediatric drug evaluation in China.

The regulatory guidelines for the research and development of paediatric drugs are still evolving in China. The formulation of the guidelines started from learning and borrowing existing experience, and gradually changed to the exploration and improvement of local guidelines, which was not only in line with international standards but also had breakthroughs, innovations and Chinese characteristics. In this paper, the current setting of paediatric drug research and development in China and corresponding technical guidelines have been introduced from regulatory perspectives, and the accessibility of further improvement in regulatory strategies has also been discussed.

[Expression of Costimulatory Molecule Tim3 on NK Cells and Its Subsets in Patients with Acute Myeloid Leukemia].

Objective: To investigate the expression of costimulatory molecule Tim3 and its subsets on NK cells in patients with acute myeloid leukemia.

Methods: 30 patients with acute myeloid leukemia treated in our hospital from August 2016 to August 2018 were randomly selected as the AML group, and 30 healthy persons in our hospital during the same period were randomly selected as the control group. The expression levels of CD56 NK cells/CD3CD56NK cells and Tim3 on CD56NK cells in peripheral blood, CD56 NK cells/CD3CD56NK cells and Tim3 on CD56NK cells in peripheral blood of the two groups were estimated.

An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis.

Ulcerative colitis (UC) is a chronic relapsing-remitting form of inflammatory bowel disease (IBD) that increases the risk of colorectal cancer, the third most common malignancy in humans. Oxidative stress is a risk factor for the development of UC. The Keap1-Nrf2-ARE pathway is one of the most important defensive mechanisms against oxidative and/or electrophilic stresses.

A systematic molecular dynamics approach to the study of peptide Keap1-Nrf2 protein-protein interaction inhibitors and its application to p62 peptides.

Protein-protein interactions (PPIs) as drug targets have been gaining growing interest, though developing drug-like small molecule PPI inhibitors remains challenging. Peptide PPI inhibitors, which can provide informative data on the PPI interface, are good starting points to develop small molecule modulators. Computational methods combining molecular dynamics simulations and binding energy calculations could give both the structural and the energetic perspective of peptide PPI inhibitors.

Application of a custom-made inlay structure to a sectional maxillary complete denture for a patient with microstomia: a clinical report.

Prosthodontic treatment for edentulous patients with microstomia is a challenge because of the constricted opening of the oral cavity. This clinical report presents the prosthetic management of an edentulous maxilla in a patient with burn-induced microstomia. A sectional maxillary complete denture was fabricated.

[Application of palatal base combined with shield above floor of mouth for restoration of acquired mandibular defect with glossectomy: report of one case].

Purpose: To evaluate the prosthetic results of application of palatal base combined with shield above the floor of mouth for restoration of acquired mandibular defect with glossectomy.

Methods: Palatal base with four wrought clasps was designed for the upper prostheses. Shield just above the floor of the mouth and buccal mucosa was fabricated to support the buccal mucosa and muscle.

[Clinical application of custom-made key-key attachment in the restoration of maxillofacial defect].

Purpose: To evaluate the usefulness of custom-made key-key attachment in restoration of maxillofacial defect.

Methods: Using key-key attachment, facial prostheses and intraoral prostheses were combined to restore dentition, maxilla and right facial defects in a female patient.

Results: Good retention of maxillofacial prostheses and intraoral prostheses were obtained.

[Application of stud structure to sectional upper complete denture for a patient with microstomia].

Purpose: Prosthetic rehabilitation with stud structure to sectional complete denture for a patient with microstomia was done and the treatment result was evaluated.

Methods: A sectional impression tray technique was used. And a custom-made palatal hinge mechanism with stud structure on the left and right side of the upper complete denture along the middle line were also designed and fabricated.

[Long-term observation of 920 porcelain fused to metal prostheses].

Purpose: To evaluate the long-term clinical results of porcelain fused to metal prostheses.

Methods: Since January 1995, 920 porcelain fused to metal prostheses were fabricated. The long-term outcome were evaluated according to the condition of the prosthese, abutment and the periodontal tissue in the respects of successful rate and causes of failure.

[Masticatory efficiency and phonetics effects of double dentition denture for cleft lip and palate patients with different base design].

Purpose: To evaluate the masticatory efficiency and phonetics in patients with cleft lip and palate before and after double dentition denture treatment, and determine the results of the treatment.

Methods: 6 patients who had cleft lip and palate with defect smaller than 1 cm x 1 cm or submucous cleft palate were selected to undergo double dentition denture treatment. Two kinds of base design were used.

[Evaluation of the speech outcomes in patients with unilateral maxillary defect rehabilitated with maxillary obturator prosthesis].

Purpose: Evaluation of the outcomes in 15 patients with unilateral maxillary defect before and after maxillofacial obturator prosthesis.

Methods: 15 patients with unilateral maxillary defect were included in this study, who received obturator prosthesis for maxillary rehabilitation. The pronunciation of the examined phonetics such as /a/, /o/, /e/, /i/, /u/ were transferred into CSL4400 before and after treatment.

[Retention and rehabilitation of complex maxillofacial defects based on bar-clip and stud attachment].

Purpose: To evaluate the application of precise attachment in restoration of complicated maxillofacial defect.

Methods: A framework with bar-clip and stud attachment was designed and fabricated. Maxillofacial prosthesis with this framework was applied to treat a patient with defects of nose, entire upper lip and the corresponding maxillofacial areas.

[The analysis of masticatory efficiency after maxillofacial prosthetic treatment for unilateral maxillary defect].

Objective: To evaluate the clinic results of maxillofacial prosthetic treatment for unilateral maxillary defect.

Methods: Masticatory efficiency was tested before and after maxillofacial prosthetic treatment for unilateral maxillary defect.

Results: There was significant difference between one week, one month, three months after treatment and before treatment(F = 0.