Analgesic effects of intrathecal curcumin in the rat formalin test.

Background: Curcumin has been reported to have anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antinociceptive activity when administered systemically. We investigated the analgesic efficacy of intrathecal curcumin in a rat model of inflammatory pain.

Methods: Male Sprague Dawley rats were prepared for intrathecal catheterization.

Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine.

Background: Microemulsion propofol produces more frequent and severe pain upon injection than lipid emulsion propofol. This study examined the analgesic effect of lidocaine-premixed microemulsion propofol in patients pretreated with remifentanil. The induction of anesthesia with this combination was compared with microemulsion propofol accompanied with either remifentanil or lidocaine.