Publications by authors named "Yong Ju Song"
Article Synopsis
- Carbonic anhydrase inhibitors (CAIs) are medications that lower intraocular pressure but can cause severe skin reactions linked to a specific human leukocyte antigen (HLA).
- The study aimed to create a fast and cost-effective screening method for detecting this HLA to prevent adverse reactions to CAIs.
- A duplex allele-specific PCR method was validated using 200 blood samples, with results matching an established reference method, confirming it as a reliable assay for HLA screening.
Primary open-angle glaucoma (POAG) can develop even within normal ranges of intraocular pressure, and this type of glaucoma (so-called 'normal-tension glaucoma [NTG]') is highly prevalent in East Asia including Korea and Japan. We conducted exome chip analysis to identify low-frequency and rare variants associated with POAG from the primary cohort (309 POAG patients and 5,400 control, all Koreans). For replication, Korean (310 POAG patients and 5,612 controls) and Japanese (565 POAG patients and 1,104 controls) cohorts were further investigated by targeted genotyping.
View Article and Find Full Text PDFPurpose: To investigate whether mass glaucoma screening relative to opportunistic case finding at a primary eye clinic is helpful for early detection of glaucoma.
Methods: Subjects referred by glaucoma screening (by non-contact tonometry and non-mydriatic fundus photography; group A, n = 220) and from a primary eye clinic (group B, n = 327) were retrospectively recruited. The positive predictive value (PPV) for glaucoma and the rate of glaucoma awareness were compared.
Purpose: To introduce cases of the use, as patch grafts, of stromal lenticules obtained by small incision lenticule extraction (SMILE) surgery.
Observations: Case 1 was a 79-year-old man who presented with Ahmed-valve-tube exposure in his left eye. His uncorrected visual acuity (UCVA) was 20/40, best-corrected visual acuity (BCVA) 20/32, and intraocular pressure (IOP) 11 mmHg.
Background: To report a case of impending extrusion of Ex-PRESS shunt treated by shunt-position adjustment.
Case Presentation: A 56-year-old Asian woman presented with impending extrusion and malposition of Ex-PRESS shunt in her left eye. The bleb of the left eye was shallow and diffuse.
Purpose: To investigate the relationship between peripapillary choroidal thickness (PCT) and choroidal vascular prominence (CVP) colocalized with retinal nerve fiber layer (RNFL) defect in primary open-angle glaucoma (POAG) eyes and to evaluate the relationship between PCT and POAG severity.
Methods: In this cross-sectional comparative study, 29 POAG patients with CVP on RNFL imaging (Group A), 70 POAG patients without CVP (Group B) and 63 healthy controls (Group C) were examined. Various factors including age, intraocular pressure (IOP), spherical equivalent (SE), axial length (AXL), central corneal thickness (CCT), peripapillary RNFL thickness, visual-field mean deviation (MD) and pattern standard deviation (PSD) were investigated.
Purpose: The purpose of this study is to investigate the influence of the Valsalva maneuver (VM) on anterior lamina cribrosa surface depth (ALCSD), and to compare normal with treated glaucomatous eyes in terms of this effect.
Methods: Thirty-two patients (32 eyes) with early-to-moderate glaucoma under treatment and 30 normal healthy participants (30 eyes) were prospectively enrolled. Study subjects performed the VM by blowing through a mouthpiece attached to a handheld manometer; expiratory pressure during the maneuver ranged from 35 to 40 mm Hg.
Purpose: To evaluate functional progression in preperimetric glaucoma (PPG) with disc hemorrhage (DH) and to determine the time interval between the first-detected DH and development of glaucomatous visual field (VF) defect.
Methods: A total of 87 patients who had been first diagnosed with PPG were enrolled. The medical records of PPG patients without DH (Group 1) and with DH (Group 2) were reviewed.
Objective: To compare peripapillary and macular choroidal thickness (PCT and MCT) between open-angle glaucoma (OAG) and normal controls using swept-source optical coherence tomography (SS-OCT), and to evaluate global and localized relationships between choroidal thickness and various factors in OAG, also using SS-OCT.
Methods: In this cross-sectional comparative study, 134 OAG patients and 73 normal controls were examined. PCT (global, 12 clock-hour sectors), MCT (global, six sectors) were measured by SS-OCT.