Development and research status of intelligent ophthalmology in China.

This paper analyzes the current status, technological developments, academic exchange platforms, and future challenges and solutions in the field of intelligent ophthalmology (IO) in China. In terms of technology, significant progress has been made in various areas, including diabetic retinopathy, fundus image analysis, quality assessment of medical artificial intelligence products, clinical research methods, technical evaluation, and industry standards. Researchers continually enhance the safety and standardization of IO technology by formulating a series of clinical application guidelines and standards.

Altered Brain Glymphatic Function at Diffusion-Tensor MRI in Pre-cirrhotic Metabolic Dysfunction-Associated Fatty Liver Disease.

Rationale And Objectives: To evaluate glymphatic function changes and their relationships with clinical features in patients with metabolic dysfunction-associated fatty liver disease (MAFLD), thereby facilitating early intervention before this disease progresses to cirrhosis.

Materials And Methods: A cross-sectional cohort of 46 pre-cirrhotic MAFLD patients and 30 age-, sex-, and education-matched controls was enrolled, with diffusion-tensor imaging (DTI) data, laboratory and neurocognitive scores collected. The DTI analysis along the perivascular space (DTI-ALPS) index was computed for qualifying glymphatic function.

Abnormalities in spontaneous brain activity and functional connectivity are associated with cognitive impairments in children with type 1 diabetes mellitus.

Background: It remains unclear whether alterations in brain function occur in the early stage of pediatric type 1 diabetes mellitus(T1DM). We aimed to examine changes in spontaneous brain activity and functional connectivity (FC) in children with T1DM using resting-state functional magnetic resonance imaging (rs-fMRI), and to pinpoint potential links between neural changes and cognitive performance.

Methods: In this study, 22 T1DM children and 21 age-, sex-matched healthy controls underwent rs-fMRI.

Dynamic tear meniscus parameters in complete blinking: insights into dry eye assessment.

Aim: To investigate the relationship between dynamic tear meniscus parameters and dry eye using an automated tear meniscus segmentation method.

Methods: The analysis of tear meniscus videos captured within 5s after a complete blink includes data from 38 participates. By processing video data, several key parameters including the average height of the tear meniscus at different lengths, the curvature of the tear meniscus's upper boundary, and the total area of the tear meniscus in each frame were calculated.

Digital coding Fano resonance based on active plasmonic metamaterials.

A novel approach that employs active plasmonic metamaterials to create a digital coding Fano resonator is proposed, to the best of our knowledge. The meta-device consists of three concentric spoof localized surface plasmon (LSP) resonators and three positive-intrinsic-negative (PIN) diodes positioned at three slits located in the middle and inner LSP resonators. Four Fano resonant modes can be independently switched by controlling the biased voltage applied to the three diodes.

[Effects of late sowing of two season crops on annual yield and resource use efficiency in rice-wheat double cropping system].

The unreasonable resource allocation and lower resource use efficiency for rice-wheat double cropping system in Jianghuai region resulted from climate change severely limit the coordinated development of annually high yield and high efficiency crops. Optimizing seasonal resource allocation through sowing date adjustment is an important way to tap the annual high-yield potential and improve resource use efficiency. To quantify the effects of sowing date of rice and wheat on annual yield and resource allocation and utilization efficiency, field experiments were conducted in 2013-2015.

Selective amplification of spoof localized surface plasmons.

Here, selective amplification of spoof localized surface plasmons (LSPs) has been demonstrated, where two coupling stubs gathering energies from the spoof LSPs resonator are designed on the back of the corrugated metal-insulator-metal ring resonator. The quadrupole mode is selected and amplified through the coupling stubs and the incorporated amplifier chip, and the measured transmission intensity has been increased from $ - {6.46}\;{\rm dB}$-6.

Gain-assisted ultra-high-Q spoof plasmonic resonator for the sensing of polar liquids.

By directly incorporating a sub-wavelength amplifier chip into the spoof plasmonic resonator, the quality (Q) factor of the original passive resonator has been significantly increased by several orders of magnitude. The spoof plasmonic resonator is composed of a corrugated ring with a slit whose optimized offset angle φ is 45°, aiming to achieve a better Q-factor. By tuning the bias voltage applied to the amplifier chip that is placed across the slit, the Q factor has been increased from 9.

Quarter-mode spoof plasmonic resonator for a microfluidic chemical sensor.

In this paper, we propose a microfluidic chemical sensor based on quarter-mode spoof plasmonic resonators with more compact overall size and higher sensitivity. First, a microfluidic channel engraved on polydimethylsiloxane is aligned to the upper part of the spoof plasmonic metal-insulator-metal (MIM) ring resonator where the strongest electric fields are observed at resonance. Although a resonant frequency shift of 270 MHz has been observed when the microfluidic channel is filled with pure ethanol, there is no resonant frequency shift when the ethanol concentration is changed from 40% to 60%.

Compact wideband plasmonic filter with flat-top transmission response based on corrugated metal-insulator-metal ring resonator.

We demonstrate a novel route to control the filtering of spoof localized surface plasmons (LSPs) on the corrugated metal-insulator-metal (MIM) ring resonator. The spoof LSPs resonance modes can be effectively tuned to achieve broad passband (covering the quadrupole mode and the hexapole mode) by selecting proper lengths in the input and output coupling area. The mutual coupling between the input and output lines produces the flat-top transmission response and sharp out-of-band rejection.

What is the optimal cutoff value of the axis-line-angle technique for evaluating trunk imbalance in coronal plane?

Background Context: Accurately evaluating the extent of trunk imbalance in the coronal plane is significant for patients before and after treatment. We preliminarily practiced a new method, axis-line-angle technique (ALAT), for evaluating coronal trunk imbalance with excellent intra-observer and interobserver reliability. Radiologists and surgeons were encouraged to use this method in clinical practice.

Research progress of synthetic biology for tanshinones.

Synthetic biology research methods which design and build a new artificial biological systems (medicinal plants or microorganisms system) with specific physiological functions through clarifying and simulating the basic law of the biosynthesis of active components of traditional Chinese medicine, is considered to be a potential method to produce an abundant resources of bioactive components. Tanshinones is a kind of diterpene quinone compounds with important pharmacological activities from traditional Chinese medicine Salvia miltiorrhiza. This article systematically introduced the research progress of the synthetic biology of S.

Identification of geranylgeranyl diphosphate synthase genes from Tripterygium wilfordii.

We found triptolide synthesis is correlated with the expressions of TwGGPPS1 and TwGGPPS4 . This lays the foundation for future studies of biosynthetic pathways for triptolide and other diterpenoids in T. wilfordii.

Spoof localized surface plasmons on ultrathin textured MIM ring resonator with enhanced resonances.

We numerically demonstrate that spoof localized surface plasmons (LSPs) resonant modes can be enhanced based on ultrathin corrugated metal-insulator-metal (MIM) ring resonator. Further enhancement of the LSPs modes has been achieved by incorporating an efficient and ease-of-integration exciting method. Quality factors of resonance peaks have become much larger and multipolar resonances modes can be easily observed on the textured MIM ring resonator excited by a microstrip line.

Spoof localized surface plasmons in corrugated ring structures excited by microstrip line.

We have investigated the fundamental and high-order spoof localized surface plasmons (LSPs) modes in the proposed corrugated ring resonator printed on a thin dielectric substrate with or without ground plane. An efficient and ease-of-integration method to excite spoof LSPs in the textured ring resonator has been adopted to suppress unwanted high-order modes and enhance fundamental modes. A multi-band-pass filter has been proposed and numerically demonstrated.

Planar spoof plasmonic ultra-wideband filter based on low-loss and compact terahertz waveguide corrugated with dumbbell grooves.

Although subwavelength planar terahertz (THz) plasmonic devices can be implemented based on planar spoof surface plasmons (SPs), they still suffer from a little high propagation loss. Here the dispersion and propagation characteristics of the spoof plasmonic waveguide composed of double metal strips corrugated with dumbbell shaped grooves have been investigated. It has been found that much lower propagation loss and longer propagation length can be achieved based on the waveguide compared with the conventional spoof plasmonic waveguide with rectangular grooves.

A 4-way wavelength demultiplexer based on the plasmonic broadband slow wave system.

We propose a broadband slow wave system based on the thin metal-insulator-metal (MIM) graded grating structure composed of two corrugated metal strips with periodic array of grooves on a thin dielectric substrate. The guided spoof surface plasmon polaritons (SSPPs) at different frequencies can be localized at different positions along the ultrathin MIM grating. By introducing specially designed non-corrugated MIM branches with specific lengths at the locations where the EM waves are trapped, the trapped EM waves can be released and propagate along these branches.

[Application of synthetic biology to sustainable utilization of Chinese materia medica resources].

Bioactive natural products are the material bases of Chinese materia medica resources. With successful applications of synthetic biology strategies to the researches and productions of taxol, artemisinin and tanshinone, etc, the potential ability of synthetic biology in the sustainable utilization of Chinese materia medica resources has been attracted by many researchers. This paper reviews the development of synthetic biology, the opportunities of sustainable utilization of Chinese materia medica resources, and the progress of synthetic biology applied to the researches of bioactive natural products.

[Construction of Saccharomyces cerevisiae whole-cell biocatalyst system for conversion miltiradiene].

Tanshinones are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza, while its biosynthetic pathway remains to be characterized. Rapid identification and characterization of the genes correlated to tanshinones biosynthesis is very important. As one of the intermediates of tanshinones biosynthesis, the ferruginol content is relative low in both root and engineered bacteria.

Bidirectional surface wave splitters excited by a cylindrical wire.

Bidirectional surface wave splitters excited by a cylindrical wire in the microwave frequency have been proposed and fabricated. Compared to the bidirectional subwavelength-slit splitter, the novelty of the proposed structure is the coupling mechanism from the cylindrical wire to the surface gratings. By designing the grating structures with different depths and the feeding wire, electromagnetic waves at the designed frequencies will be confined and guided in the predetermined opposite directions.

fabC of Streptomyces lydicus involvement in the biosynthesis of streptolydigin.

Streptolydigin, a secondary metabolite produced by Streptomyces lydicus, is a potent inhibitor of bacterial RNA polymerases. It has been suggested that streptolydigin biosynthesis is associated with polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS). Thus, there is great interest in understanding the role of fatty acid biosynthesis in the biosynthesis of streptolydigin.