Publications by authors named "Yong Jin Heo"
Article Synopsis
- - Non-small cell lung cancer (NSCLC) is categorized into two main types: lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LSCC), but some tumors display mixed characteristics that may be influenced more by other factors than histology alone.
- - A study using data from 691 patients identified five molecular subtypes of NSCLC, including one associated with the PI3K-Akt pathway that correlates with high rates of metastasis and poor survival, regardless of the specific type of NSCLC.
- - The research highlights the immune microenvironment's role, revealing different immune cell compositions and neoantigen levels across subtypes, which can help predict patient outcomes; immunological subtypes showed better responses to
Multi-omics approaches are novel frameworks that integrate multiple omics datasets generated from the same patients to better understand the molecular and clinical features of cancers. A wide range of emerging omics and multi-view clustering algorithms now provide unprecedented opportunities to further classify cancers into subtypes, improve the survival prediction and therapeutic outcome of these subtypes, and understand key pathophysiological processes through different molecular layers. In this review, we overview the concept and rationale of multi-omics approaches in cancer research.
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