Long-term consumption of green tea protects the mental health of middle-aged and older adult men by improving inflammation levels.

Background: Middle-aged and older adult men are at a heightened risk of depression. Green tea, as a popular beverage, has drawn widespread attention for its health benefits. However, there remains controversy over the effects of green tea on combating depression and regulating hormones.

Development and validation of a nomogram for predicting the outcome of metabolic syndrome among people living with HIV after antiretroviral therapy in China.

Background: The prevalence of metabolic syndrome among people living with HIV (PLWH) is increasing worldwide. This study aimed to develop and validate a nomogram to predict the risk of metabolic syndrome in PLWH receiving antiretroviral therapy (ART) in China, accounting for both traditional and HIV-specific risk factors.

Methods: A retrospective cohort study was conducted among PLWH receiving ART at a designated treatment center in Yinzhou District, China.

Assessment of non-tumor liver parenchyma damage in advanced gastric cancer treatment with transarterial infusion chemotherapy: a study using imaging and hepatic injury indicators.

Introduction: This study aimed to evaluate non-tumor liver parenchymal injury in advanced gastric cancer patients undergoing transarterial infusion chemotherapy (TAI) using imaging parameters and liver injury biomarkers, providing objective evidence for early detection of drug-induced liver injury.

Methods: A retrospective analysis was conducted on 52 advanced gastric cancer patients who received TAI at our center from July 2015 to July 2023. Abdominal CT images and laboratory data were collected before and after treatment.

Development of Cytolytic Iridium-Complexed Octaarginine Peptide Albumin Nanomedicine for Hepatocellular Carcinoma Treatment.

Objective: Hepatocellular carcinoma is one of the most challenging malignancies and has high incidence and mortality rates worldwide. Digital subtraction angiography (DSA)-guided hepatic arterial infusion of the standard chemotherapeutic agent oxaliplatin (OXA) has the advantages of both precision and efficacy, making it an important therapeutic strategy for advanced-stage liver cancer. However, patients receiving this treatment still face severe systemic toxicity and poor tolerability of oxaliplatin.

Dual Functional Radioactive Gel-Microspheres for Combinatorial Radioembolization and Photothermal Therapy of Hepatocellular Carcinoma.

Transarterial radioembolization (TARE) is an established clinical therapy for treating patients with intermediate to advanced hepatocellular carcinoma (HCC) or those who cannot undergo radical treatment. However, the delivery of a high radiation dose is associated with several adverse effects, such as radiation pneumonitis. Additionally, the available radioactive microspheres (MSs) are dense and unsuitable for interventional delivery.

McMurray's test is influenced by perimeniscal synovitis in degenerative meniscus tears.

Background: McMurray's test is a useful physical examination in determining meniscus tears, yet its sensitivity is only 38-62%. Furthermore, the relationship between degenerative meniscus tears (DMT) and mechanical symptoms during McMurray's test is not well defined. Perimeniscal synovitis occurs in osteoarthritic (OA) knees, inducing localized symptoms such as posterior knee pain in medial meniscus posterior horn DMTs.

The clinical performance of robotic assisted navigation system versus conventional freehand technique for percutaneous transthoracic needle biopsy.

This study aimed to assess the feasibility and safety of robotic-assisted navigation system for percutaneous transthoracic needle biopsy (PTNB), compare it with conventional freehand technique, and evaluate its generalizability across operators with varying experience levels. After excluding 5 patients in whom robotic-assisted PTNB could not be performed due to technical problems, a total of 50 patients with robotic-assisted PTNB and 200 patients who performed freehand puncture were included. Using propensity score matching (PSM) to match two groups of patients and simulate a randomized controlled scenario.

Cinnamaldehyde mitigates acute myocardial infarction by regulating ferroptosis through the PI3K-AKT signaling pathway.

Objective: This investigation sought to elucidate the protective efficacy of Cinnamaldehyde (CA) against acute myocardial infarction (AMI) while investigating its therapeutic mechanisms through the integration of network pharmacology technology as well as in vitro and in vivo experiments.

Methods: An AMI rat model was constructed via left anterior descending coronary artery ligation after the experimental rats were subjected to continuous intragastric administration of CA over a 14-day period. In parallel, an AMI cell model was established by subjecting neonatal primary rat cardiomyocytes to glucose/oxygen deprivation (OGD).

Identification of Key Proteomic Markers for Enhanced Conjugated Linoleic Acid Biosynthesis in Lactating Goats via Linseed Oil Supplementation.

This study investigated the effects of linseed oil (LO) supplementation on conjugated linoleic acid (CLA) biosynthesis in lactating Saanen goats. Goats (DIM = 96 ± 14 days) were divided into control ( = 6) and LO treatment ( = 6) groups. LO supplementation was implemented in both short- and long-term experimental settings.

Mechanical properties of double-solid waste cement stabilized Macadam.

Cement stabilized macadam base has high strength and excellent bearing capacity, but the problems of water-temperature sensitivity, easy shrinkage cracking and large demand for aggregate limit the further development and application of cement stabilized macadam base. At the same time, with the economy development, the increase of solid waste, such as waste tires and construction waste, has caused great pressure on the ecological environment. In order to ensure better mechanical properties and shrinkage resistance of the cement stabilized macadam on the basis of full use of solid waste.

Durability and environmental evaluation of rice husk ash sustainable concrete containing carbon nanotubes.

The environmental issues in the construction industry have garnered considerable attention in numerous studies. Ecologically sustainable green concrete addresses environmental challenges in the construction industry. This study investigates the impact of multi-walled carbon nanotubes (0-0.

Radiological safety assessment of monazite industry worker due to NORM inhalation.

Monazite is used as a raw material for the production of rare earth elements. The workers in the monazite industry are exposed to radiation from the raw material. Therefore, internal radiation dose should be assessed for radiological safety assessment of the workers.

The Predictive Value of Lactate Dehydrogenase for Viral Suppression in Newly Diagnosed People Living With HIV on Antiretroviral Therapy: A Retrospective Cohort Study.

Purpose: Rapid initiation of antiretroviral therapy (ART) in people living with HIV (PLWH) is crucial for achieving viral suppression and improving clinical outcomes. Serum lactate dehydrogenase (LDH) levels serve as a readily accessible and rapid clinical biomarker, has significant predictive potential in various viral diseases. This study aims to evaluate the predictive value of LDH levels for viral suppression in the context of rapid ART initiation.

Copper excess induces autophagy dysfunction and mitochondrial ROS-ferroptosis progression, inhibits cellular biosynthesis of milk protein and lipid in bovine mammary epithelial cells.

Excessive copper (Cu) has the potential risk to ecosystems and organism health, with its impact on dairy cow mammary glands being not well-defined. This study used a bovine mammary epithelial cell (MAC-T) model to explore how copper excess affects cellular oxidative stress, autophagy, ferroptosis, and protein and lipid biosynthesis in milk. Results showed the increased intracellular ROS, MDA, and CAT (P < 0.

NK cell exhaustion in Wilson's disease revealed by single-cell RNA sequencing predicts the prognosis of cholecystitis.

Metabolic abnormalities associated with liver disease have a significant impact on the risk and prognosis of cholecystitis. However, the underlying mechanism remains to be elucidated. Here, we investigated this issue using Wilson's disease (WD) as a model, which is a genetic disorder characterized by impaired mitochondrial function and copper metabolism.

MRI-Based Multifunctional Nanoliposomes for Enhanced HCC Therapy and Diagnosis.

The morbidity and mortality rates of hepatocellular carcinoma (HCC) are high and continue to increase. The antitumor effects of single therapies are limited because of tumor heterogeneity and drug resistance, and the lack of real-time monitoring of tumor progression during the treatment process leads to poor therapeutic outcomes. Therefore, novel nanodelivery platforms combining tumor therapy and diagnosis have garnered extensive attention.

Comparative efficacy of uterine artery embolization versus laparoscopic myomectomy in treating uterine fibroids: a propensity score matched analysis.

Objective: The aim of this study was to comparatively analyze the therapeutic effects of uterine artery embolization (UAE) and laparoscopic myomectomy (LM) on uterine fibroids to determine which treatment method is more beneficial for patients.

Materials And Methods: A retrospective study was conducted on 396 patients who underwent UAE (n = 153) or LM (n = 243) treatment from April 2010 to September 2019. After 1:1 propensity score matching (PSM), a comparative analysis was conducted on surgical trauma magnitude, postoperative recovery time, improvement in associated symptoms and quality of life, surgical adverse events, recurrence rates, and further interventions.

A lightweight multi scale fusion network for IGBT ultrasonic tomography image segmentation.

The Insulated Gate Bipolar Transistor (IGBT) is a crucial power semiconductor device, and the integrity of its internal structure directly influences both its electrical performance and long-term reliability. However, the precise semantic segmentation of IGBT ultrasonic tomographic images poses several challenges, primarily due to high-density noise interference and visual distortion caused by target warping. To address these challenges, this paper constructs a dedicated IGBT ultrasonic tomography (IUT) dataset using Scanning Acoustic Microscopy (SAM) and proposes a lightweight Multi-Scale Fusion Network (LMFNet) aimed at improving segmentation accuracy and processing efficiency in ultrasonic images analysis.

Hotspots of genetic change in Yersinia pestis.

The relative contributions of mutation rate variation, selection, and recombination in shaping genomic variation in bacterial populations remain poorly understood. Here we analyze 3318 Yersinia pestis genomes, spanning nearly a century and including 2336 newly sequenced strains, to shed light on the patterns of genetic diversity and variation distribution at the population level. We identify 45 genomic regions ("hot regions", HRs) that, although comprising a minor fraction of the genome, are hotbeds of genetic variation.

Evaluating the efficacy of intra-articular polydioxanone (PDO) injections as a novel viscosupplement in osteoarthritis treatment.

Aims: Osteoarthritis (OA) is a chronic joint disorder marked by cartilage breakdown, bone alterations, and inflammation, leading to significant pain and disability. Current therapeutic strategies, ranging from lifestyle interventions to pharmacological and surgical treatments, offer limited efficacy and are often accompanied by side effects. This study investigates the potential of Polydioxanone (PDO), a biocompatible synthetic polymer, as a novel intra-articular (IA) viscosupplement in OA.

Three-dimensional reconstruction method for layered structures based on a frequency modulated continuous wave terahertz radar.

The feasibility of employing a continuous-wave terahertz detection system for non-contact and non-destructive testing (NDT) in multi-layered bonding structures is assessed in this study. The paper introduces the detection principle of terahertz frequency modulated continuous wave (FMCW) radar and outlines the two-dimensional (2D) scanning platform, which integrates optical lenses, three linear actuators, a control platform, and data acquisition units. Experimental results on two types of insulation with prefabricated defects demonstrate the capability of terahertz waves for transparent inspection imaging.

Enhancing wound healing through innovative technologies: microneedle patches and iontophoresis.

Introduction: Wound healing is a complex process involving multiple stages, including inflammation, proliferation, and remodeling. Effective wound management strategies are essential for accelerating healing and improving outcomes. The CELLADEEP patch, incorporating iontophoresis therapy and microneedle technology, was evaluated for its potential to enhance the wound healing process.