A novel glucagon analog with an extended half-life, HM15136, normalizes glucose levels in rodent models of congenital hyperinsulinism.

Congenital hyperinsulinism (CHI) is a rare genetic condition characterized by uncontrolled insulin secretion, resulting in hypoglycemia. Although glucagon has lately been regarded as a therapeutic option for CHI, its use is severely hampered by its poor solubility and stability at physiological pH, as well as its short duration of action. To address these constraints, we developed HM15136, a novel long-acting glucagon analog composed of a glucagon analog conjugated to the Fc fragment of human immunoglobulin G4 via a polyethylene glycol linker.

Acoustic source identification of an axial fan in a duct considering the rotation effect.

For developing the quiet axial fans, the spatial distribution of acoustic source parameters over the source plane provides essential information. In this study, the previously suggested source identification technique by authors is newly applied to an axial fan. To obtain the acoustic source parameters in a duct, one should overcome many technical difficulties related with: the turbulent flow, high order modes, rotating sources, inverse estimation.