Special Issue "Recent Advances in the Food Safety and Quality Management Techniques".

Food quality and safety are essential from the health and fiscal points of view [...

Associations of plasma biomarkers with cerebral perfusion and structure in Alzheimer's disease.

Plasma biomarkers have great potential in the screening, diagnosis, and monitoring of Alzheimer's disease (AD). However, findings on their associations with cerebral perfusion and structural changes are inconclusive. We examined both cross-sectional and longitudinal associations between plasma biomarkers and cerebral blood flow (CBF), gray matter (GM) volume, and white matter (WM) integrity.

Efficacy and Safety of Chemotherapy or EGFR-TKIs as First-Line Therapy in NSCLC Patients Harboring Non-Ex 20 Ins Uncommon EGFR Mutations: A Retrospective Study in China.

Background: Uncommon EGFR mutations are a kind of heterogeneous group of mutations with various responses to EGFR-TKIs and are often excluded from most prospective clinical trials. In this real-world retrospective study, we retrospectively compared the efficacy and safety of chemotherapy or various generations of EGFR-TKIs as first-line therapy in NSCLC Chinese patients harboring non-ex 20 ins uncommon EGFR mutations.

Methods: We enrolled 139 NSCLC patients with non-ex 20 ins uncommon EGFR mutations in this study retrospectively.

The impact of the development level of rural e-commerce on the depressive symptoms among rural older adult individuals.

Background: In the context of China, where the demographic trend of population aging intertwines with the rapid advancement of information digitalization, rural older adult individuals, who are part of a vulnerable population, are witnessing a deteriorating depression status. The proliferation of rural e-commerce, which fuels the digital economic revolution in rural areas, is concurrently affecting the depressive symptoms among rural older adult individuals.

Methods: This study uses longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS) and applies a multi-period Difference-in-Differences (DID) model to explore how rural e-commerce affects the depressive symptoms among rural older adult individuals.

Analysis of risk factors for sepsis-related liver injury and construction of a prediction model.

Background: Sepsis is a leading cause of mortality in critically ill patients, and the liver is a key organ affected by sepsis. Sepsis-related liver injury (SRLI) is an independent risk factor for multiple organ dysfunction syndrome (MODS) and mortality. However, there is no clear diagnostic standard for SRLI, making early detection and intervention challenging.

Histone acetylation alteration by KAT6A inhibitor WM-1119 suppresses IgE-mediated mast cell activation and allergic inflammation via reduction in AP-1 signaling.

Activation of immunoglobulin E (IgE)-associated mast cells (MCs) triggers the onset of pro-inflammatory signals associated with type I allergic diseases. Although histone acetylation changes have been associated with inflammatory diseases, the impact of lysine-acetyltransferase (KAT) inhibitors on IgE-mediated MCs function is unclear. Potential anti-allergic effects of the KAT6A inhibitor WM-1119 on IgE-mediated MCs activation and allergic inflammation were examined in this study.

Discovery of marine ent-eudesmane sesquiterpenoids as angiogenic inhibitors via suppressing VEGF-A/VEGFR2 signaling pathway.

Increasing evidence underscores the pivotal role of tumor angiogenesis for tumorigenesis and tumor metastasis. Inhibiting the tumor angiogenesis process is a promising therapeutic approach for cancer. In order to search for natural angiogenic inhibitors, the chemical constitutes of a marine-derived fungus Eutypella sp.

Spectral Fingerprinting of Tencha Processing: Optimising the Detection of Total Free Amino Acid Content in Processing Lines by Hyperspectral Analysis.

The quality and flavor of tea leaves are significantly influenced by chemical composition, with the content of free amino acids serving as a key indicator for assessing the quality of Tencha. Accurately and quickly measuring free amino acids during tea processing is crucial for monitoring and optimizing production processes. However, traditional chemical analysis methods are often time-consuming and costly, limiting their application in real-time quality control.

The positive implication of natural antioxidants on oxidative stress-mediated diabetes mellitus complications.

The complementary intervention to modulate diabetes mellitus (DM) metabolism has recently brought the global attention, since DM has become among the global burden diseases. Where, several related pathways elevate the production of superoxide in consequences. For example, the flux of glycation-derived end products (AGEs) could lead to the deactivation of insulin signaling pathways.

Altered neurovascular coupling in semantic variant primary progressive aphasia.

Background: Semantic variant primary progressive aphasia (svPPA) is one of the main clinical phenotypes of frontotemporal lobar degeneration. Changes in both neuronal activity and cerebral perfusion have been observed in svPPA, suggesting a possible breakdown of neurovascular coupling (NVC).

Objective: To investigate alterations in NVC and their correlations with clinical manifestations in svPPA patients.

Dual-Time Point 68Ga-FAPI-04 PET/CT Improves Tumor Delineation and Cervical Lymph Node Metastasis Identification in Patients With Head and Neck Squamous Cell Carcinoma.

Purpose: The purpose of this study was to evaluate the benefit of dual-time point 68Ga-FAPI-04 PET/CT in staging head and neck squamous cell carcinoma (HNSCC).

Patients And Methods: Sixty-nine treatment-naive patients with HNSCC were enrolled. Each patient underwent whole-body 68Ga-FAPI-04 PET/CT at approximately 30 minutes postinjection and a delayed scan in head and neck region at 2 hours.

Homogeneous synthesis of cationic celluloses with broad-spectrum antibacterial activities for the treatment of vaginitis in mice.

Microbial infection is a significant health issue for humans. Despite the development of numerous antibiotics, the continuous rise of drug-resistant bacteria highlights the urgent need for new materials to combat these problems. In this study, four water-soluble quaternized cellulose (QC) derivatives with degrees of substitution (DS) ranging from 0.

Duckweed (Lemna minor L.) as a natural-based solution completely offsets the increase in ammonia volatilization induced by soil drying and wetting cycles in irrigated paddies.

One of the primary pathways of nitrogen loss in rice fields, ammonia (NH) volatilization resulting in low nitrogen use efficiency and contributes significantly to near-surface atmospheric pollution. Duckweed (Lemna minor L.), a common small floating plant in rice fields, often completely covers the water surface.

Enantioselective construction of C-B axially chiral alkenylborons by nickel-catalyzed radical relayed reductive coupling.

The catalytic asymmetric synthesis of axially chiral alkenes remains a daunting challenge due to the lower rotational barrier, especially for longer stereogenic axis (e.g. C-B axis).

Shared differential factors underlying individual spontaneous neural activity abnormalities in major depressive disorder.

Background: In contemporary neuroimaging studies, it has been observed that patients with major depressive disorder (MDD) exhibit aberrant spontaneous neural activity, commonly quantified through the amplitude of low-frequency fluctuations (ALFF). However, the substantial individual heterogeneity among patients poses a challenge to reaching a unified conclusion.

Methods: To address this variability, our study adopts a novel framework to parse individualized ALFF abnormalities.

Developing fluorescence hyperspectral imaging methods for non-invasive detection of herbicide safeners action mechanism and effectiveness.

Herbicide safeners are considered key agents for plant protection that reduce the harmful impacts of herbicides on crops and the environment in general, but traditional evaluation methods for their effectiveness are time-consuming and labor-intensive. In this study, a rapid and non-destructive method was proposed using chlorophyll fluorescence and hyperspectral imaging that combined with machine learning models. Besides, chemometric analysis was utilized to reveal the action mechanism between the wheat crop (Triticum aestivum L.

Mapping multi-regional functional connectivity of astrocyte-neuronal networks during behaviors.

Significance: Diverse behaviors rely on coordinated activity and multi-regional functional connectivity within astrocyte-neuronal networks. However, current techniques for simultaneously measuring astrocytic and neuronal activities across multiple brain regions during behaviors remain limited.

Aim: We propose a multi-fiber solution that can simultaneously record activities of astrocyte-neuronal networks across multiple regions during behaviors.

Advances in Gas Detection of Pattern Recognition Algorithms for Chemiresistive Gas Sensor.

Gas detection and monitoring are critical to protect human health and safeguard the environment and ecosystems. Chemiresistive sensors are widely used in gas monitoring due to their ease of fabrication, high customizability, mechanical flexibility, and fast response time. However, with the rapid development of industrialization and technology, the main challenges faced by chemiresistive gas sensors are poor selectivity and insufficient anti-interference stability in complex application environments.

Intelligent agriculture: deep learning in UAV-based remote sensing imagery for crop diseases and pests detection.

Controlling crop diseases and pests is essential for intelligent agriculture (IA) due to the significant reduction in crop yield and quality caused by these problems. In recent years, the remote sensing (RS) areas has been prevailed over by unmanned aerial vehicle (UAV)-based applications. Herein, by using methods such as keyword co-contribution analysis and author co-occurrence analysis in bibliometrics, we found out the hot-spots of this field.