Single-nucleus RNA-sequencing of orbitofrontal cortex in rat model of methamphetamine-induced sensitization.

The behavioral sensitization, characterized by escalated behavioral responses triggered by recurrent exposure to psychostimulants, involves neurobiological mechanisms that are brain-region and cell-type specific. Enduring neuroadaptive changes have been observed in response to methamphetamine (METH) within the orbitofrontal cortex (OFC), the cell-type specific transcriptional alterations in response to METH sensitization remain understudied. In this study, we utilized Single-nucleus RNA-sequencing (snRNA-seq) to profile the gene expression changes in the OFC of a rat METH sensitization model.

Influencing factors associated with quality of life and depression among COVID-19 survivors during convalescence.

This study aims to investigate influencing factors of quality of life (QoL) and depression among COVID-19 survivors during convalescence. A cross-sectional study was conducted in November 2020 in Wuhan, China. Information on social support, physical activity, QoL and depressive symptoms were assessed using self-administered questionnaires.

Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study.

Adenosine triphosphate (ATP) biomolecules play critial roles in the biomineralization process during the formation of amorphous calcium phosphate composites (ACPC), and ACPC is an important drug carrier due to its significant advantages of biocompatibility and biodegradability. Hence, studying the behavior of ACPC nanodrug carriers is crucial to investigate the structural regulation of biomimetic minerals and calcium phosphate (CaP)-based drug delivery systems. However, it is difficult to probe these interactions using traditional characterization methods.

Associations of physical activity and fruit and vegetable intake with well-being and depressive symptoms among obese schoolchildren in Wuhan, China: a cross-sectional study.

Background: The prevalence of childhood obesity is increasing and psychological disorder is a common comorbidity of obesity. We investigated the associations of physical activity (PA) and fruit and vegetable (FV) intake with well-being and depressive symptoms among obese schoolchildren.

Methods: Participants included 188 obese children aged 9.

One-pot environmentally friendly approach toward highly catalytically active bimetal-nanoparticle-graphene hybrids.

A one-pot universal approach with simple metal sputtering onto room temperature ionic liquids has been developed to prepare bimetal-nanoparticle (NP)-graphene hybrids, and the process is environmentally friendly and completely free of additives and byproducts. The graphene-supported bimetallic NPs have an Ag-based core and an Au/Pd-rich shell, demonstrated by the scanning transmission electron microscopy. The X-ray absorption near-edge spectroscopy using synchrotron radiation reveals the occurrence of charge redistribution at both the Ag@Au and Ag@Pd core-shell interfaces.

[Genetic diversity of adenoviruses in bats of China].

Adenovirus remains a significant threat to public health. Recent studies showed that bats can harbor diverse adenoviruses. To further investigate the distribution and genetic diversity of bat adenoviruses in China, we collected throat and anal swab samples of 11 bat species from 6 provinces of China, including Beijing, Hunan, Jiangxi, Yunnan, Guizhou and Hainan.

[Applications of synchrotron-based X-ray absorption near-edge structure spectroscopy in identifying solid state phosphorus speciation: a review].

Solid state phosphorous is an important phosphorus speciation controlling the phosphorous bioavailability and mobility in the environment. Synchrotron-based X-ray absorption near-edge structure (XANES) spectroscopy, with its unique advantage of being a non-destructive method in identifying the local chemical information of target element at molecular level in situ, has become one of the frontier technologies for characterizing the speciation of chemical substances and clarifying the microscopic mechanisms of chemical reactions, attracting extensive attention in the field of environmental chemistry. This paper briefly introduced the basic theory of phosphorus XANES spectroscopy, summarized the applications of XANES spectroscopy in the researches of solid state phosphorus speciation in minerals, soils, and organic fertilizers, and analyzed the challenges and prospects of the applications of XANES spectroscopy in identifying the solid state phosphorus speciation in the environmental samples.

[Complete genome sequence of Coxsackievirus B5 (CVB5/09) strain isolated in China and its phylogenetic analysis].

An outbreak of hand foot and mouth disease occurred in Shang dong, China in 2009. Almost 20% of patient's swabs was positive for Coxsackie virus B5 (CVB5) identified by RT-PCR and sequencing. It was suggested that CVB5 may be another important pathogen for HFMD.