Structural modification of lactoferrin by epigallocatechin gallate: elucidation of its structure and exploration of its potential in promoting osteoblast proliferation.

Lactoferrin (LF) and epigallocatechin gallate (EGCG) are recognized for their potent osteogenic properties. However, the osteogenic activity of LF-EGCG complexes is not fully understood. In this study, both non-covalent and covalent LF-EGCG complexes with different LF : EGCG ratios were prepared, and their effects on the LF structure and thermal stability were investigated using circular dichroism, Fourier transform infrared spectroscopy, fluorescence spectroscopy, Raman spectroscopy, and differential scanning calorimetry.

Polylactic acid amine-sensitive colorimetric indicator film loaded with eugenol/coumarin derivatives: Towards freshness indication and shelf-life extension of chilled pork.

The action of microorganisms can lead to a decrease in food freshness and cause food safety issues. Traditional packaging can only provide a certain antimicrobial effect and cannot indicate the freshness of food, which can no longer meet the needs of consumers. The preparation of intelligent packaging films with antimicrobial effects and freshness indication is an effective solution.

Sensitive and Anisotropic Room-Temperature Terahertz Photodetection in Quasi-1D Nodal-Line Semimetal NbNiTe.

Low-dimensional topological materials merge the benefits of reduced dimensionality with the nontrivial topological phases, garnering significant attention as promising candidates for next-generation optoelectronic devices. The quasi-1D nodal-line semimetal NbNiTe showcases distinct in-plane anisotropy alongside robust Dirac nodal-line points, rendering it a fascinating platform for exploring the intricate interplay between novel quantum states of matter and low-energy radiation. Here, sensitive and anisotropic terahertz photodetection driven by Dirac fermions and the intrinsic anisotropic properties of NbNiTe are presented.

CFD-DEM simulation of the motion law of magnetic flocs during waste slurry disposal in shield tunnel.

The sustainable treatment and reuse of waste slurry in slurry shield construction have gained significant attention. This paper explores the application of magnetic flocculation technology for treating slurry. The CFD-DEM coupling method simulates the migration of magnetic flocs during centrifugation.

An association between average daily sleep duration and gallstones in US adults.

Despite extensive research on the impact of health factors and sleep, the specific association between average daily sleep duration and the prevalence of gallstones in adults has not been thoroughly investigated. This study analyzes data from 7,441 individuals from the NHANES 2017-2020 dataset, using exclusion criteria to refine the participant pool. Employing multivariate logistic regression and subgroup analyses while controlling for potential confounders, we assessed the association between average daily sleep duration and the prevalence of gallstones.

Anti-PD-L1 envafolimab combined with anti-VEGF suvemcitug in pretreated solid tumors and hepatocellular carcinoma: an open-label phase II study with safety run-in stage.

Background: Immune checkpoint inhibitors (ICIs) combined with anti-vascular endothelial growth factor (VEGF) have been the standard first-line treatment of hepatocellular carcinoma (HCC). However, the efficacy of this combination in post-line treatment is still unknown. This study aimed to evaluate the efficacy and safety of the combination of anti-PD-L1 envafolimab and novel humanized anti-VEGF suvemcitug as second-line treatment for patients with HCC.

Micro-Electro Nanofibrous Dressings Based on PVDF-AgNPs as Wound Healing Materials to Promote Healing in Active Areas.

Purpose: The purpose of this study is to develop an innovative solution for chronic wounds in high-mobility areas, such as joints, where conventional treatments are hindered by passive healing mechanisms and the need for immobilization. By designing a micro-electro-Nanofiber dressing composed of piezoelectric polyvinylidene fluoride (PVDF) integrated with antimicrobial silver nanoparticles (AgNPs), this research aims to address the dual challenges of promoting effective wound healing and maintaining joint mobility.

Methods: Herein, we developed a novel micro-electro-Nanofiber dressing using electrospinning technology, incorporating polyvinylidene fluoride (PVDF) with silver nanoparticles (AgNPs).

The efficacy and safety of suvemcitug, envafolimab, and FOLFIRI in microsatellite-stable or mismatch repair-proficient colorectal cancer: preliminary results of a phase 2 study.

Purpose: This phase II study is designed to evaluate the combination therapy involving suvemcitug and envafolimab with FOLFIRI in microsatellite-stable or mismatch repair-proficient (MSS/pMMR) colorectal cancer (CRC) in the second-line treatment setting.

Methods: This study is a non-randomized, open-label prospective study comprising multiple cohorts (NCT05148195). Here, we only report the data from the CRC cohort.

The nonlinear association between body roundness index and infertility in married women.

Infertility is increasingly linked to obesity, especially visceral fat accumulation. The Body Roundness Index (BRI) provides a precise quantification of body and visceral fat but its implications for infertility risks and diagnostic value are yet to be fully determined. This study analyzed data from 1,305 married women aged 20-45 years, drawn from the National Health and Nutrition Examination Survey (NHANES).

Spin Canting Promoted Manipulation of Exchange Bias in a Perpendicular Coupled FeGaTe/CrSBr Magnetic van der Waals Heterostructure.

Recently, two-dimensional (2D) van der Waals (vdW) magnetic materials have emerged as a promising platform for studying exchange bias (EB) phenomena due to their atomically flat surfaces and highly versatile stacking configurations. Although complex spin configurations between 2D vdW interfaces introduce challenges in understanding their underlying mechanisms, they can offer more possibilities in realizing effective manipulations. In this study, we present a spin-orthogonal arranged 2D FeGaTe (FGaT)/CrSBr vdW heterostructure, realizing the EB effect with the bias field as large as 1730 Oe at 2 K.

Preparation of Cello-Oligosaccharides by Precise-Controlled Enzymatic Depolymerization and Its Amphiphilic Functionalization for High-Oil Load Emulsification.

Cello-oligosaccharides (COS) are gaining great attention for their prebiotic-like properties, e.g., boosting gut health by promoting beneficial bacteria and improving digestion.

A Large-Scale Building Unsupervised Extraction Method Leveraging Airborne LiDAR Point Clouds and Remote Sensing Images Based on a Dual P-Snake Model.

Automatic large-scale building extraction from the LiDAR point clouds and remote sensing images is a growing focus in the fields of the sensor applications and remote sensing. However, this building extraction task remains highly challenging due to the complexity of building sizes, shapes, and surrounding environments. In addition, the discreteness, sparsity, and irregular distribution of point clouds, lighting, and shadows, as well as occlusions of the images, also seriously affect the accuracy of building extraction.

Glutinous rice gel as all-natural ink supply for extrusion-based food 3D printing - the chemical basis of gel printability.

In this study, four varieties of glutinous rice were screened out of 18 varieties as representative model inks. Gel prepared using variety WN9612 of high amylose content displayed high viscosity and large overall print deviation (OPD = 17.4 ± 0.

Effect of exogenous thermophilic biocontrol agent inoculum on the high temperature chicken manure composting.

Introduction: Aerobic composting is an effective method for utilizing chicken manure. However, its low carbon to nitrogen (C/N) ratio leads to slow heating and short high-temperature phases, which reduce composting efficiency and product quality.

Methods: To address this issue, splinted mushroom cultivation residues were added to adjust the C/N ratio, and exogenous thermophilic composting strains were introduced to increase composting temperature.

Efficacy of dexmedetomidine epidural anesthesia combined with nano-silver polyurethane dressing in gynecological surgery and its influence on hemodynamics, inflammatory response and postoperative recovery.

Objective: To evaluate the effectiveness of dexmedetomidine epidural anesthesia combined with nano-silver polyurethane dressing in gynecological surgery.

Methods: This retrospective study analyzed data of 80 patients who underwent epidural anesthesia at Jinan Maternal and Child Health Care Hospital from January 2018 to May 2022. The patients treated with propofol and routine postoperative wound treatment were assigned into a control group, while the patients treated with dexmedetomidine and nano-silver polyurethane dressing were classified into an observation group.

Photothermally enhanced antibacterial wound healing using albumin-loaded tanshinone IIA and IR780 nanoparticles.

Chronic and infected wounds, particularly those caused by bacterial infections, present significant challenges in medical treatment. This study aimed to develop a novel nanoparticle formulation to enhance wound healing by combining antimicrobial and photothermal therapy using albumin as a carrier for Tanshinone IIA and the near-infrared photothermal agent IR780. The nanoparticles were synthesized to exploit the antimicrobial effects of Tanshinone IIA and the photothermal properties of IR780 when exposed to near-infrared laser irradiation.

Withdrawn: Camel FGF21 Protein Enhances FGF21 Signaling and its Targeted Compounds Screening.

Unlabelled: The article has been withdrawn at the request of the author. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.

The systemic inflammatory response index is associated with chronic kidney disease in patients with hypertension: data from the national health and nutrition examination study 1999-2018.

Background: Studies have shown that in hypertensive patients, chronic kidney disease (CKD) is associated with a poor prognosis. Inflammation is a highly important factor in the progression of CKD. Detecting systemic inflammation and intervening promptly in patients with hypertension may help reduce the risk of CKD.

Zein and gum arabic nanoparticles: potential enhancers of immunomodulatory functional activity of selenium-containing peptides.

Food-derived nanomaterials optimizing bioactive peptides is an emerging route in the functional food field. Zein and gum arabic (GA) possess favorable encapsulation properties for controlled release, targeted delivery and stabilization of food bioactive ingredients, and thus are considered as promising carriers for delivery systems. In order to improve the bioavailability of rice selenium-containing peptide TSeMMM (T), the nanoparticles (ZTGNs) containing peptide T, zein and GA have been previously prepared.