Gamma-aminobutyric acid secreted from islet beta-cells modulates exocrine secretion in rat pancreas.

Aim: To investigate the role of endogenous gamma-amino-butyric acid (GABA) in pancreatic exocrine secretion.

Methods: The isolated, vascularly perfused rat pancreas was employed in this study to eliminate the possible influences of extrinsic nerves and hormones. Cholecystokinin (CCK; 10 pmol/L) was intra-arterially given to stimulate exocrine secretion of the pancreas.

Effects of gamma-aminobutyric acid on action of gastrin-releasing peptidergic neurons in exocrine secretion of isolated, perfused rat pancreas.

Introduction: gamma-Aminobutyric acid (GABA) has been reported to enhance exocrine secretion evoked by intrinsic neuronal excitation in the pancreas.

Aim: To see the effect of GABA on the action of gastrin-releasing peptide (GRP)ergic neurons in exocrine secretion of the pancreas.

Methodology: Pancreatic neurons were excited by electrical field stimulation (EFS) in the isolated, perfused rat pancreas.

Endogenous somatostatin inhibits interaction of insulin and cholecystokinin on exocrine secretion of isolated, perfused rat pancreas.

Introduction: Although somatostatin inhibits pancreatic exocrine secretion, the inhibitory mechanism of endogenous somatostatin is not clearly understood.

Aim: To investigate the effect of endogenous somatostatin on the interaction between endogenous insulin and exogenous cholecystokinin (CCK) in exocrine secretion of the totally isolated, perfused rat pancreas.

Methodology: Endogenous releases of somatostatin and insulin were induced by 18 mM glucose.