Antioxidant and antimicrobial sodium alginate/sodium carboxymethyl cellulose films loaded with self-assembled hesperidin nanorods for fruits preservation.

To develop green food packaging films, we prepared carrier-free hesperidin (HSD) nanoparticles by self-assembly technique and loaded them into Sodium Alginate (SA) and Sodium Carboxymethyl Cellulose (CMC) matrices to obtain the composite film. SEM and TEM imaging revealed that these nanoparticles exhibited a rod-like structure (hesperidin nanorods, HSD NRs). Compared to HSD, the water solubility and biological activity of HSD NRs were significantly higher.

Primary Study on Effect of Extraction Methods on the Properties and Activities of Polysaccharides from .

, a traditional Miao medicine with significant clinical potential, is rich in polysaccharides. Despite its importance, there is a scarcity of research on the structure and activities of these polysaccharides. In this study, polysaccharides from (GJPs) were extracted using various methods, including heated reflux extraction (HRE), acidic extraction (ACE), alkaline extraction (AAE), microwave-assisted extraction (MAE), enzymatic extraction (EAE), pressurized liquid extraction (PLE), and deep eutectic solvents extraction (DESE).

Correlations of Expression Levels of microRNA-206 and microRNA-186 in the Serum With Disease Severity and Prognosis of Elderly Patients With Vascular Dementia.

Objective To investigate the correlations of the expression levels of microRNA (miR)-206 and miR-186 in the serum with the disease severity and prognosis of elderly patients with vascular dementia (VD). Methods A total of 104 elderly patients with VD treated in Dalian Municipal Central Hospital from October 2020 to May 2023 were selected into the VD group and 104 healthy volunteers who underwent physical examinations were enrolled in the control group.Baseline data of both groups were collected,and fluorescence quantitative PCR was used to measure the expression levels of miR-206 and miR-186 in the serum.

[Exploring the mechanism of HIV infection on T lymphocyte mitochondrial damage based on MAPK pathway].

Objective To clarify the mechanism that HIV infection mediates mitochondrial damage of CD4 T lymphocytes (CD4 T cells) through mitogen-activated protein kinase (MAPK) pathway. Methods From October 1st, 2022 to March 31st, 2023, 47 HIV-infected people who received antiretroviral therapy (ART) for 4 years were recruited, including 22 immune non-responders (INR) and 25 responders (IR); and 26 sex and age-matched control participants (HC) who were negative for HCV, HBV, and HIV infections. The immune parameters were analyzed by flow cytometry.

Variations in volatile components and biological activities of essential oils from Citrus aurantium 'changshanhuyou' at different growth and ripening stages.

Citrus aurantium 'Changshanhuyou' is one kind of fruit that is beneficial to human health. Most research focus on active substances such as flavonoids and limonoids, but few on the essential oils from its peels. This study analyzed the volatile components of Huyou peel essential oil (HYEO) throughout the growth and ripening stages including beginning, middle, end of growth period, and post- ripening stage (60 days of storage) by GC-MS.

Novel heterozygous mutation of CACNA2D1 gene in a Chinese family with arrhythmia.

Background: Primary electrical disorders (PEDs) are a group of cardiac rhythm abnormalities that occur in the absence of detectable structural heart disease and are a significant cause of sudden cardiac death (SCD). The initiation of cardiac muscle contraction and relaxation is orchestrated by the action potential (AP), generated through ionic changes across the membrane. Mutations in the AP-related gene CACNA2D1 have been identified as a causative factor for PED.

Random walk in random permutation set theory.

Random walk is an explainable approach for modeling natural processes at the molecular level. The random permutation set theory (RPST) serves as a framework for uncertainty reasoning, extending the applicability of Dempster-Shafer theory. Recent explorations indicate a promising link between RPST and random walk.

Molecular Dynamics Study on Wear Resistance of High Entropy Alloy Coatings Considering the Effect of Temperature.

High entropy alloys have excellent wear resistance, so they have great application prospects in the fields of wear resistance and surface protection. In this study, the wear resistance of the FeNiCrCoCu high entropy alloy coating was systematically analyzed by the molecular dynamics method. FeNiCrCoCu high entropy alloy was used as a coating material to adhere to the surface of a Cu matrix.

Exogenous microbubbles contribute to valorization of microalgal compounds by ultrasound-assisted extraction.

Ultrasound-assisted extraction (UAE) shows great potential in exploiting microalgal compounds. However, upgrading the extraction system lacks concerns. This study proposes a novel sono-reactor featuring a microbubble distributor for increasing bubble abundance and correspondingly improving microalgal compound extraction.

Functional analysis of circSNYJ1/miR-142-5p/CCND1 regulatory axis in non-small cell lung cancer.

Non-small cell lung cancer (NSCLC), the most prevalent form of lung cancer, accounts for approximately 85% of all lung cancer diagnoses. Circular RNAs (circRNAs) are non-coding RNAs that play an active role in gene expression regulation, influencing cell growth, migration, and apoptosis. Here, we aimed to investigate the function of circSNYJ1 in NSCLC.

Random Permutation Set Reasoning.

In artificial intelligence, it is crucial for pattern recognition systems to process data with uncertain information, necessitating uncertainty reasoning approaches such as evidence theory. As an orderable extension of evidence theory, random permutation set (RPS) theory has received increasing attention. However, RPS theory lacks a suitable generation method for the element order of permutation mass function (PMF) and an efficient determination method for the fusion order of permutation orthogonal sum (POS).

An Embeddable Implicit IUVD Representation for Part-Based 3D Human Surface Reconstruction.

To reconstruct a 3D human surface from a single image, it is crucial to simultaneously consider human pose, shape, and clothing details. Recent approaches have combined parametric body models (such as SMPL), which capture body pose and shape priors, with neural implicit functions that flexibly learn clothing details. However, this combined representation introduces additional computation, e.

Proprotein convertase subtilisin/kexin type 9 inhibitors protect against contrast-associated acute kidney injury in patients with atherosclerotic cardiovascular disease.

Background And Aims: Contrast-associated acute kidney injury (CA-AKI) may occur in patients undergoing medical procedures involving x-rays and radiocontrast media, potentially resulting in prolonged renal impairment. However, no effective treatments are available. Therefore, this study aimed to investigate the efficacy of evolocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, in reducing CA-AKI incidence among patients with atherosclerotic cardiovascular disease (ASCVD) undergoing percutaneous coronary intervention.

Lipid Nanoparticle-Mediated Delivery of CRISPR-Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism.

Non-alcoholic fatty liver disease (NAFLD) is a prominent cause of various chronic metabolic hepatic diseases with limited therapeutics. Rubicon, an essential regulator in lysosomal degradation, is reported to exacerbate hepatic steatosis in NAFLD mice and patients, indicating its probability of being a therapeutic target for NAFLD treatment. In this study, the therapeutic potential of Rubicon blockage is investigated.

Metabolic self-feeding in HBV-associated hepatocarcinoma centered on feedback between circulation lipids and the cellular MAPK/mTOR axis.

Introduction: Hepatitis B Virus (HBV) is widely recognized as a "metabolic virus" that disrupts hepatic metabolic homeostasis, rendering it one of the foremost risk factors for hepatocellular carcinoma (HCC). Except for antiviral therapy, the fundamental principles underlying HBV and HBV HCC have remained unchanged, limiting HCC treatment options.

Objectives: In this study, we aim to identify the distinctive metabolic profile of HBV-associated HCC, with the promise of identifying novel metabolic targets that confer survival advantages and ultimately impede cancer progression.

Disease-induced changes in bacterial and fungal communities from plant below- and aboveground compartments.

The plant microbes are an integral part of the host and play fundamental roles in plant growth and health. There is evidence indicating that plants have the ability to attract beneficial microorganisms through their roots in order to defend against pathogens. However, the mechanisms of plant microbial community assembly from below- to aboveground compartments under pathogen infection remain unclear.

Oxygen-Independent Radiodynamic Therapy: Radiation-Boosted Chemodynamics for Reprogramming the Tumor Immune Environment and Enhancing Antitumor Immune Response.

Radiodynamic therapy (RDT) has emerged as a promising modality for cancer treatment, offering notable advantages such as deep tissue penetration and radiocatalytic generation of oxygen free radicals. However, the oxygen-dependent nature of RDT imposes limitations on its efficacy in hypoxic conditions, particularly in modulating and eliminating radioresistant immune suppression cells. A novel approach involving the creation of a "super" tetrahedron polyoxometalate (POM) cluster, Fe-POM, has been developed for radiation boosted chemodynamic catalysis to enable oxygen-independent RDT in hypoxic conditions.

Development and validation of nomograms for predicting prognosis in patients with solitary HCC: A TRIPOD-Compliant study.

Objective: To develop and validate nomograms for predicting the OS and CSS of patients with Solitary Hepatocellular Carcinoma (HCC).

Methods: Using the TRIPOD guidelines, this study identified 5206 patients in the Surveillance, Epidemiology, and End Results (SEER) 17 registry database. All patients were randomly divided in a ratio of 7:3 into a training cohort (n = 3646) and a validation cohort (n = 1560), and the Chinese independent cohort (n = 307) constituted the external validation group.

Role of Type VI secretion system in pathogenic remodeling of host gut microbiota during Aeromonas veronii infection.

Intestinal microbial disturbance is a direct cause of host disease. The bacterial Type VI secretion system (T6SS) often plays a crucial role in the fitness of pathogenic bacteria by delivering toxic effectors into target cells. However, its impact on the gut microbiota and host pathogenesis is poorly understood.

Evaluation of multiscale mechanisms of ultrasound-assisted extraction from porous plant materials: Experiment and modeling on this intensified process.

Ultrasound-assisted extraction (UAE) is an intensified mass transfer process, which can utilize natural resources effectively, but still lacks detailed mechanisms for multiscale effects. This study investigates the mass transfer mechanisms of UAE combined with material's pore structure at multiscale. Porous material was prepared by roasting green coffee beans (GCB) at 120 °C (RCB120) and 180 °C (RCB180), and their UAE efficiency for phytochemicals (caffeine, trigonelline, chlorogenic acid, caffeic acid) were evaluated by experiment and modeling.

Comparative analysis of the clinical features of nonvalvular atrial fibrillation among Tibetan, Han, and Hui patients in Qinghai Province, China.

Global nonvalvular AF rises, impacting health severely. In Qinghai, China's diverse setting, studying AF among varied ethnic groups is crucial OBJECTIVES: The purpose of this study was to compares cardiac features in AF among Tibetan, Han, and Hui patients to develop tailored prevention and treatment strategies for this region, the goal was to enhance the understanding of AF and provide an empirical basis for developing prevention and treatment strategies specific to this region METHODS: This study included a total of 3445 Tibetan, Han, and Hui patients diagnosed with nonvalvular atrial fibrillation and treated at the Qinghai Cardiovascular and Cerebrovascular Specialist Hospital, China, between January 2019 and January 2021. We analyzed the differences in cardiac structure, comorbidities, and other influencing factors among the different ethnic groups RESULTS: We found significant differences in gender, age, smoking history, lone atrial fibrillation, left heart failure, dilated cardiomyopathy, and diabetes between Tibetan, Han, and Hui patients (P < 0.

An advance in novel intelligent sensory technologies: From an implicit-tracking perspective of food perception.

Food sensory evaluation mainly includes explicit and implicit measurement methods. Implicit measures of consumer perception are gaining significant attention in food sensory and consumer science as they provide effective, subconscious, objective analysis. A wide range of advanced technologies are now available for analyzing physiological and psychological responses, including facial analysis technology, neuroimaging technology, autonomic nervous system technology, and behavioral pattern measurement.