Evaluation of intratympanic dexamethasone for treatment of refractory sudden sensorineural hearing loss.

Objective: To observe and compare the efficacy of intratympanic application of dexamethasone (DXM) for the treatment of refractory sudden sensorineural hearing loss (SSNHL), the DXM was given in three different ways: by tympanic membrane injection, by drip through a ventilation tube, and by perfusion through a round window catheter.

Methods: We conducted a nonrandomized retrospective clinical trial involving 55 patients with refractory SSNHL. For 21 patients (the perfusion group), DXM (2.

Allelic imbalance and abnormal expression of FHIT in endemic nasopharyngeal carcinoma: association with clinicopathological features.

The FHIT gene is involved in the pathogenesis of many cancers. The aim of this study was to investigate allelic imbalance (AI) pattern at FHIT locus and alteration of FHIT gene in nasopharyngeal carcinoma (NPC) and analyzed potential correlation between AI, FHIT mRNA expression and clinicopathological factors. We examined AI, including loss of heterozygosity (LOH) and microsatellite instability (MSI), at FHIT locus in 41 cases of NPC by microsatellite analysis and FHIT gene status in 30 cases of NPC by nested reverse transcriptase-polymerase chain reaction and DNA sequencing.

[Clinical observation of sensorineural hearing loss in patients suffering from nasopharyngeal carcinoma after radiotherapy].

Objective: To study the extent and incidence of sensorineural hearing loss (SNHL) after radiotherapy (RT).

Methods: Twenty-eight patients with diagnosed nasopharyngeal carcinoma (NPC) were selected. The pure-tone audiography, auditory brain stem evoked response (ABR), impedance audiometry and evoked otoacoustic emissions (EOAE) recordings were performed before RT, 1 month, 1, 2 and 5 years after RT.

[Curative effect of transtympanic perfusion of gentamicin on unilateral Ménière's disease].

Objective: To investigate the curative effect of transtympanic perfusion of gentamicin on unilateral Ménière's disease.

Methods: Twenty-three patients with unilateral Ménière's disease, 14 males and 9 females, aged 24 - 61, all with vertigo, tinnitus and ear fullness sensation to different degrees, were treated with transtympanic perfusion of gentamicin via the tympanostomy tube, 12 mg per 3 hours and 5 times a day. Pure tone audiometry and caloric test were performed every day before treatment.