Publications by authors named "Yong Chang Gao"
Article Synopsis
- Chronic rejection (CR) is a major challenge for allograft survival, and oxymatrine (OMT), a compound from traditional Chinese medicine, shows promise for treating this condition.
- In experiments with B6 mice, OMT was found to reduce pathological damage in heart transplants, inhibit harmful T cell activities, and enhance regulatory T cell differentiation, leading to improved graft survival.
- OMT appears to work by blocking specific signaling pathways (like mTOR and TGF-β-Smad 2/3), which helps decrease immune responses and fibrosis in the transplanted tissues, indicating potential for future therapeutic approaches.
Article Synopsis
- Allograft rejection is a significant challenge in organ transplantation, and this study investigates the effects of recombinant human IL-37 (rhIL-37) in improving graft survival in a mouse model.
- The research found that rhIL-37 treatment led to long-term acceptance of transplanted hearts by reducing immune cell infiltration and modulating cytokine profiles, specifically increasing Treg cells and decreasing inflammatory cytokines like TNF-α.
- The findings suggest that IL-37 may be a promising therapeutic option for preventing organ rejection, highlighting its role in immune regulation through pathways like p-mTOR.
This work describes how dark fermentation (DF), anaerobic digestion (AD) and microbial fuel cells (MFC) and solid-liquid separation can be integrated to co-produce valuable biochemicals (hydrogen and methane), bioelectricity and biofertilizers. Two integrated systems (System 1: AD+MFC, and System 2: DF+AD+MFC) are described and compared to a traditional one-stage AD system in converting a mixture (COD=124±8.1gO2kg(-1)Fresh Matter) of swine manure and rice bran.
View Article and Find Full Text PDFObjective: To investigate the clinicopathological characteristics and prognosis in breast cancer with brain metastasis (BCBM).
Methods: The clinical data of 137 BCBM from June 2002 to June 2008 was reviewed and analyzed. Their molecular subtypes were categorized based on detection of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) expression.