Arthroscopic pullout repair of posterior root tear of the medial meniscus: the anterior approach using medial collateral ligament pie-crusting release.

Posterior root tears of the medial meniscus are frequently encountered and should be repaired if possible to prevent osteoarthritis of the medial compartment. Various surgical techniques have been proposed to repair posterior root tears. The anterior arthroscopic approach can cause an iatrogenic chondral injury due to the narrow medial joint space.

Integrated connection to neighborhood storytelling network, education, and chronic disease knowledge among African Americans and Latinos in Los Angeles.

Combining key ideas from the knowledge-gap hypothesis and communication infrastructure theory, the present study aimed to explain the relations among individuals' education, access to community-based communication resources, and knowledge of chronic diseases (diabetes, hypertension, breast cancer, and prostate cancer) among African Americans and Latinos in Los Angeles. Rather than explore the effect of isolated communication resources, this study explored the effect of an integrated connection to community-based storytellers on chronic disease knowledge. The authors hypothesized that individuals' access to a community-based communication infrastructure for obtaining and sharing information functions as an intervening step in the process where social inequality factors such as education lead to chronic disease knowledge gaps in a local community context.

Simvastatin induces Foxp3+ T regulatory cells by modulation of transforming growth factor-beta signal transduction.

Statins are widely used drugs for the treatment of hypercholesterolaemia. A number of recent studies have suggested that statins also have pleiotropic effects on immune responses and statins have proven to be effective in the treatment of autoimmune diseases in animal models. Foxp3(+) T regulatory cells are a unique subset of CD4(+) T cells that mediate immunosuppression.

Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis.

Statins are cholesterol-lowing drugs with pleiotropic effects including cytotoxicity to cancer cells. In this study, we investigated the signaling pathways leading to apoptosis by simvastatin. Simvastatin induced cardinal features of apoptosis including increased DNA fragmentation, disruption of mitochondrial membrane potential (MMP), and increased caspase-3 activity by depleting isoprenoids in MethA fibrosarcoma cells.

Communication, neighbourhood belonging and household hurricane preparedness.

This paper reports on an examination of data on how local residents in Tuscaloosa, a mid-sized city in the state of Alabama, United States, responded to Hurricane Ivan of September 2004. The evaluation revealed that an integrated connection to community-level communication resources-comprising local media, community organisations and interpersonal networks-has a direct impact on the likelihood of engaging in pre-hurricane preparedness activities and an indirect effect on during-hurricane preparedness activities. Neighbourhood belonging mediated the relation between an integrated connection to community-level communication resources and during-hurricane preparedness activities.

Arthroscopic suprascapular nerve decompression at the suprascapular notch.

Release of a transverse scapular ligament (TSL) is indicated for the entrapment of the suprascapular nerve (SSN). Previous arthroscopic techniques use step-wise reference landmarks leading to the notch to identify a TSL, and the key landmarks are the conoid ligament of the coracoclavicular ligament and the coracoid. This technique needs considerable amount of fibro-fatty tissue removal, which is time-consuming procedure.

Remifentanil for postoperative patient-controlled analgesia after laparoscopic-assisted vaginal hysterectomy: dose-finding study.

Background: This randomized, double-blinded clinical study was designed to compare the efficacy and safety of three regimens of intravenous (IV) patient-controlled analgesia (PCA) with remifentanil for postoperative analgesia after laparoscopic-assisted vaginal hysterectomy during the first 24 postoperative hours.

Methods: Thirty-four patients were randomly allocated into three groups. The first group received IV remifentanil PCA at a basal rate of 0.

Medial opening wedge high-tibial osteotomy using a kinematic navigation system versus a conventional method: a 1-year retrospective, comparative study.

High tibial osteotomy is a realignment procedure to transfer weight-bearing load to the intact compartment of the knee to alleviate symptoms, slow disease progression, and defer subsequent total knee arthroplasty. To prevent overcorrection or undercorrection, it is not only important to have an exact preoperative calculation of the desired correction angle, but it is also critical to have an accurate intraoperative technique. 85 consecutive patients (90 knees) were enrolled, who were available at 1-year follow-up after a medial opening wedge high tibial osteotomy using a kinematic navigation system or a conventional method, for medial unicompartmental osteoarthritis.

Arthroscopic treatment of patellofemoral soft tissue impingement after posterior stabilized total knee arthroplasty.

Patellar clunk syndrome is due to a suprapatellar fibrous nodule which develops at the junction between the proximal patella and the quadriceps tendon after total knee arthroplasty. Twelve patients (12 knees) who underwent arthroscopic treatment for the painful patellar crepitus or clunk after total knee arthroplasty had been followed at least for 1 year were enrolled. The average onset of symptom was 10.

Simvastatin induces caspase-independent apoptosis in LPS-activated RAW264.7 macrophage cells.

Macrophages participate in several inflammatory pathologies such as sepsis and arthritis. We examined the effect of simvastatin on the LPS-induced proinflammatory macrophage RAW264.7 cells.

Modulation of the transactivation function of nuclear factor-kappaB by lipopolysaccharide in RAW264.7 macrophages.

In macrophages, nuclear factor kappa B (NF-kappaB) activation has important roles for the regulation of an inducible nitric oxide synthase (iNOS), several pro-inflammatory cytokines, and anti-apoptotic proteins. In order to analyze the transactivation process of NF-kappaB by lipopolysaccharide (LPS), we used the GAL4-NF-kappaB-p65 fusion protein. This chimeric NF-kappaB is activated transcriptionally only if NF-kappaB transactivation domain is active.

Cytosolic NADP(+)-dependent isocitrate dehydrogenase protects macrophages from LPS-induced nitric oxide and reactive oxygen species.

Macrophages activated by microbial lipopolysaccharides (LPS) produce bursts of nitric oxide and reactive oxygen species (ROS). Redox protection systems are essential for the survival of the macrophages since the nitric oxide and ROS can be toxic to them as well as to pathogens. Using suppression subtractive hybridization (SSH) we found that cytosolic NADP(+)-dependent isocitrate dehydrogenase (IDPc) is strongly upregulated by nitric oxide in macrophages.

LPS-induced CD53 expression: a protection mechanism against oxidative and radiation stress.

The CD53 antigen is a member of the tetraspanin membrane protein family that is expressed in the lymphoid-myeloid lineage. Its biological role remains unknown. Using microarrays, we identified CD53 as one of the principal genes up-regulated by exposure of macrophages to LPS.