Publications by authors named "Yona R Levites"
Article Synopsis
- Parkinson's disease and similar disorders involve chronic neuroinflammation, which has led to the exploration of anti-inflammatory treatments to potentially alleviate symptoms.
- In a study using mice expressing a mutation associated with PD, the introduction of the anti-inflammatory cytokine Il-10 unexpectedly resulted in increased neuroinflammation and early mortality instead of improvement.
- Further investigation revealed that a variant of Il-10, with mainly immunosuppressive effects (vIl-10), also led to worsened outcomes, suggesting that manipulating immune responses can have complicated and sometimes harmful effects in neurodegenerative diseases.
Amyloid-beta (A beta) has been identified as a key component in Alzheimer's disease (AD). Significant in vitro and human pathological data suggest that intraneuronal accumulation of A beta peptides plays an early role in the neurodegenerative cascade. We hypothesized that targeting an antibody-based therapeutic to specifically abrogate intracellular A beta accumulation could prevent or slow disease onset.
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