Toll-Like receptor 3-mediated interferon-β production is suppressed by oncostatin m and a broader epithelial-mesenchymal transition program.

Background: Patients with Triple Negative Breast Cancer (TNBC) currently lack targeted therapies, and consequently face higher mortality rates when compared to patients with other breast cancer subtypes. The tumor microenvironment (TME) cytokine Oncostatin M (OSM) reprograms TNBC cells to a more stem-like/mesenchymal state, conferring aggressive cancer cell properties such as enhanced migration and invasion, increased tumor-initiating capacity, and intrinsic resistance to the current standards of care. In contrast to OSM, Interferon-β (IFN-β) promotes a more differentiated, epithelial cell phenotype in addition to its role as an activator of anti-tumor immunity.

Nanopore direct RNA sequencing reveals N-methyladenosine and polyadenylation landscapes on long non-coding RNAs in Arabidopsis thaliana.

Background: Long non-coding RNAs (lncRNAs) play important roles in various biological processes, including stage development in plants. N-methyladenosine (mA) modification and polyadenylation are noteworthy regulatory processes that impact transcript functions by modulating their abundance. However, the specific landscapes of mA modification and polyadenylation on lncRNAs remain largely unexplored.

Association of Yeo's index with clinical outcomes in rheumatic mitral stenosis.

Yeo's index, the product of the mitral leaflet separation index and dimensionless index of mitral valve (MV), was recently described to accurately identify severe rheumatic mitral stenosis (MS). We assess the association between Yeo's index and clinical outcomes in patients with rheumatic MS. We studied 297 patients with rheumatic MS.

American College of Surgeons survival calculator for biliary tract cancers: using machine learning to individualize predictions.

Background: Although cancer prognosis is most commonly estimated by tumor stage, survival is multifactorial. Our objective was to develop an American College of Surgeons "Biliary Tract Cancer Survival Calculator" prototype using machine learning to generate personalized survival estimates based on patient, tumor, and treatment factors.

Methods: The National Cancer Database was used to identify all patients with biliary tract malignancies between 2010 and 2017 including intrahepatic bile duct, extrahepatic bile duct, and gallbladder cancers.

Usual On-therapy Ranges of Drug Concentrations in Patients with Atrial Fibrillation Treated with Direct Oral Anticoagulants: A Systematic Review and Meta-analysis.

Background:  Although most patients with atrial fibrillation (AF) receiving a direct oral anticoagulant (DOAC) do not require drug concentration measurements, there are situations where such information could be useful. Existing guidance documents provide usual on-therapy ranges for drug concentrations, but these have important limitations.

Methods:  This is a systematic review and meta-analysis of studies reporting trough and peak levels of DOAC regimens approved for stroke prevention in AF.

A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics.

Existing microbiota databases are biased toward adult samples, hampering accurate profiling of the infant gut microbiome. Here, we generated a metagenome-assembled genome inventory for children (MAGIC) from a large collection of bulk and viral-like particle-enriched metagenomes from 0 to 7 years of age, encompassing 3,299 prokaryotic and 139,624 viral species-level genomes, 8.5% and 63.

Thermodynamic analysis of the effect of palm stearin on fully hydrogenated soybean oil coatings in granular micronutrient premixes.

This study examined the phase behaviour and temperature-dependent viscosity of palm stearin and fully hydrogenated soybean oil (FHSBO) mixtures to understand the stability of FHSBO coatings on micronutrient premixes. The Hildebrand equation showed that palm stearin/FHSBO mixtures form liquid solutions, while DSC data indicated partial immiscibility in the solid phase. The melting temperatures and enthalpies of fusion are composition dependent, ranging from 67 °C and 138 J/g for 100 % FHSBO to 13 °C and 71 J/g for 100 % palm stearin.

Progressive resistance training improves single-leg vertical jump after anterior cruciate ligament reconstruction: Non-randomized controlled trial study.

Objectives: The study was investigating the effect of a progressive resistance training program on the recovery of patients with anterior cruciate ligament reconstruction in terms of kinematics, kinetics and muscle strength.

Design: Longitudinal cohort study.

Setting: Hospital laboratory.

The Three-Dimensional Investigation of the Radiographic Boundary of Mandibular Full-Arch Distalization in Different Facial Patterns.

Objective: Mandibular full-arch distalization (MFD) is a popular approach, particularly in non-extraction cases. However, we still cannot confirm whether facial patterns affect the amount of limits. This study aimed to determine the anatomical MFD limits in patients with different facial patterns.

Revalidation of Proactive Gastrostomy Tube Placement Guidelines for Head and Neck Cancer Patients Receiving Helical Intensity-Modulated Radiotherapy.

The Royal Brisbane and Women's Hospital (RBWH) Swallowing and Nutrition Management Guidelines for Patients with Head and Neck Cancer were developed to enable evidence-based decision-making by the Head and Neck Multidisciplinary Team (H&N MDT) regarding enteral nutrition support options. The purpose of this study was to revalidate these guidelines in a cohort of patients receiving helical intensity-modulated radiotherapy (H-IMRT) compared to a historical cohort who received primarily 3D-conformal radiotherapy. Eligible patients attending the RBWH H&N MDT between 2013 and 2014 (n = 315) were assessed by the guidelines, with high-risk patients being recommended proactive gastrostomy tube placement.

Understanding the beliefs, motivations and perceived barriers of physiotherapists toward career development and related post-graduate training opportunities: a qualitative study.

Background: In light of impending physiotherapy workforce shortages in Australia and updates to career progression pathways for physiotherapists internationally, it is important to understand the beliefs and considerations that underpin decisions to pursue career development opportunities from the perspective of physiotherapists.

Purpose: To investigate physiotherapists' beliefs, motivations and perceived barriers toward career development opportunities, and explore influences which impact the decisions regarding whether and how to undertake career development in physiotherapy.

Methods: Qualitative study using one-on-one semi-structured interviews.

Online Media Consumption, Fear, Mental Wellbeing, and Behavioral Compliance During the COVID-19 Pandemic: A Longitudinal Study.

This study explored how online media consumption, fear, mental wellbeing, and behavioral compliance with COVID-19 measures were related to one another during the COVID-19 pandemic. Employing a four-wave longitudinal survey research design ( = 1,092), this study found positive relationships between online media consumption and fear of COVID-19, between fear of COVID-19 and behavioral compliance, and between behavioral compliance and mental wellbeing in the general Dutch population. Results showed a negative relationship between fear of COVID-19 and mental wellbeing.

Opportunities for System Neuroscience.

Systems neuroscience explores the intricate organization and dynamic function of neural circuits and networks within the brain. By elucidating how these complex networks integrate to execute mental operations, this field aims to deepen our understanding of the biological basis of cognition, behavior, and consciousness. In this chapter, we outline the promising future of systems neuroscience, highlighting the emerging opportunities afforded by powerful technological innovations and their applications.

SPECT/CT imaging of EGFR-positive head and neck squamous cell carcinoma patient-derived xenografts with Pb-PSC-panitumumab in NRG mice.

Background: The objective of this research was the development and evaluation of Pb-labelled panitumumab (Pb-PSC-panitumumab) as an immuno-SPECT radioligand for the detection of EGFR + head and neck squamous cell carcinoma (HNSCC) in a patient-derived xenograft (PDX) mouse model. The 51.9 h physical half-life and favourable γ-emission (279 keV; 81%) of Pb offer an excellent opportunity for developing immuno-SPECT radioligands.

Experiences of siblings of children with chronic pediatric conditions: a qualitative systematic review.

Unlabelled: The needs of well siblings of children with chronic pediatric conditions (CPCs) are often overlooked as parents tend to direct their attention toward the child with CPC. This highlights the need to explore the experiences of these siblings to better inform the implementation of healthcare services. To consolidate the most up-to-date qualitative evidence regarding well siblings' perceptions and experiences of living with children with CPC.

Larger size of Conn's adenoma is associated with lower cure rates post adrenalectomy.

Background: The cure for patients with primary hyperaldosteronism (PHA) secondary to solitary adrenal adenoma is adrenalectomy. We investigated the impact of size of Conns' tumour on hypertension resolution in a multi-ethnic South East Asian Cohort.

Methods: Retrospective cohort study of patients who underwent surgery for PHA between January 2010 to December 2022 was performed.

A simplified geriatric prognostic index to survival in older Asian patients with diffuse large B-Cell lymphoma treated with standard chemo-immunotherapy.

While there are many proposed clinical prediction models for diffuse large B-cell lymphoma, like the International Prognostic Index (IPI), revised IPI and the National Comprehensive Cancer Network IPI, there is no widely used model for older patients. A recent study proposed a Geriatric Prognostic Index (GPI) validated in a Norwegian cohort, using independent predictors involving demographic, biochemical and functional parameters. This study aims to validate the GPI in an Asian cohort and simplify the GPI for ease of clinical application.

Effects of metformin on binge-like ethanol drinking and adenosine monophosphate kinase signaling in inbred high drinking in the dark line 1 mice.

Background: Adenosine monophosphate-activated protein kinase (AMPK) signaling plays a vital role in regulating cellular metabolism and energy throughout the body. Ethanol and cocaine both reduce AMPK activity in addiction-related brain regions. Though AMPK activation has been found to reduce cocaine seeking, its role in harmful drinking and alcohol use disorder (AUD) progression remains unclear.

Efficacy of acupuncture in ameliorating anxiety in Parkinson's disease: a systematic review and meta-analysis with trial sequential analysis.

Background: Although numerous studies have explored acupuncture for alleviating Parkinson's disease (PD) symptoms, specific methods focusing on reducing anxiety in these patients are lacking. Preliminary research indicates that acupuncture may improve anxiety in patients with Parkinson's; however, high-quality evidence is lacking. Therefore, we conducted a meta-analysis and trial sequential analysis (TSA) to assess the efficacy of acupuncture in managing anxiety symptoms in PD.

Eight ways to support faculty with Entrustable Professional Activities.

Competency Based Medical Education (CBME) is pushing the medical profession to be more accountable in our standards of assessment. This has led us to focus our efforts at the top of Miller's pyramid, where we aim to see what the trainee 'does' in the clinical environment. In Canadian Royal College specialty training, this has come in the form of workplace-based supervision of trainees performing Entrustable Professional Activities (EPAs).