Publications by authors named "Yolentha Maria Slootweg"
Article Synopsis
- Pregnant women are screened for red blood cell (RBC) antibodies to identify those at risk for severe hemolytic disease of the fetus and newborn (HDFN), with a focus on measuring antibody titers and conducting the antibody-dependent cellular cytotoxicity (ADCC) test.
- A titer cut-off of ≥16 has been determined to be effective for sensitivity (100%) but has a low positive predictive value (17%); variations were noted among different antibodies, with anti-c showing the highest rate of exceeding the cut-off.
- The study concludes that a titer cut-off of ≥16 is sufficient to identify risks for severe HDFN, while the ADCC test can refine risk assessment, prompting recommendations for
Background: The successful introduction of prophylaxis with anti-RhD immunoglobulin has resulted in a significant decline of pregnancy-related RhD immunizations but also has decreased the availability of naturally immunized women as (new) anti-D donors. An influx of new donors is necessary to maintain a sufficient pool of anti-D donors. We investigated motivators, barriers, and predictors for anti-D donorship in RhD-immunized women.
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