Publications by authors named "Yolentha M Slootweg"
Problem: For health care providers to ensure appropriate decision-making in clinical settings during childbirth, facilitators and barriers must be identified.
Background: Women who experience a sense of control by participating in the decision-making process, are more likely to have a positive birth experience. However, decision-making may involve hierarchies of close observation and control.
Background And Objectives: To evaluate the severity of haemolytic disease of the foetus and newborn (HDFN) in subsequent pregnancies with RhD immunization and to identify predictive factors for severe disease.
Materials And Methods: Nationwide prospective cohort study, including all pregnant women with RhD antibodies. All women with at least two pregnancies with RhD antibodies and RhD-positive foetuses were selected.
Article Synopsis
- A study was conducted to assess the knowledge and experiences of Dutch obstetric care providers about red blood cell (RBC) alloimmunization during pregnancy, highlighting the potential emotional impact on patients due to inadequate counseling.
- Only about 10% of providers completed the questionnaire, with only 7% demonstrating sufficient overall knowledge, although 60% were well-informed about RhD immunization and prophylaxis.
- Key knowledge gaps included the importance of non-RhD antibodies, criteria for administering extra RhD prophylaxis, and how to interpret lab results, indicating a need for improved awareness and education among healthcare providers.
Article Synopsis
- Pregnant women are screened for red blood cell (RBC) antibodies to identify those at risk for severe hemolytic disease of the fetus and newborn (HDFN), with a focus on measuring antibody titers and conducting the antibody-dependent cellular cytotoxicity (ADCC) test.
- A titer cut-off of ≥16 has been determined to be effective for sensitivity (100%) but has a low positive predictive value (17%); variations were noted among different antibodies, with anti-c showing the highest rate of exceeding the cut-off.
- The study concludes that a titer cut-off of ≥16 is sufficient to identify risks for severe HDFN, while the ADCC test can refine risk assessment, prompting recommendations for
Background: There is controversy on critical cut-off values of laboratory testing to select pregnancies at increased risk for anti-Kell-mediated hemolytic disease of the fetus and newborn. Without early detection and treatment, anti-Kell-mediated hemolytic disease of the fetus and newborn may result in progressive fetal anemia, fetal hydrops, asphyxia, and perinatal death.
Objective: We aimed to determine the value of repeated anti-Kell titer determination and biological activity measurement using the antibody-dependent cellular cytotoxicity test determination in the management of pregnancies at risk for anti-Kell-mediated hemolytic disease of the fetus and newborn.
Background: The successful introduction of prophylaxis with anti-RhD immunoglobulin has resulted in a significant decline of pregnancy-related RhD immunizations but also has decreased the availability of naturally immunized women as (new) anti-D donors. An influx of new donors is necessary to maintain a sufficient pool of anti-D donors. We investigated motivators, barriers, and predictors for anti-D donorship in RhD-immunized women.
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