Efficacy, safety, and correlative biomarkers of bintrafusp alfa in recurrent or metastatic nasopharyngeal cancer patients: a phase II clinical trial.

Background: The strategy of dual blockade of TGF-β and PD-L1 pathways has not been previously tested in platinum-refractory recurrent or metastatic nasopharyngeal cancer (R/M NPC) patients. This study aimed to evaluate the safety and efficacy of bintrafusp alfa in refractory R/M NPC patients.

Methods: In this single-arm, single-centre phase II clinical trial, 38 histologically confirmed R/M NPC patients were enrolled and administered with bintrafusp alfa every 2 weeks.

Ultrasound elastography in the head and neck. Part II. Accuracy for malignancy.

Ultrasound elastography (USE) describes a variety of ultrasound-based imaging techniques that measure tissue stiffness properties, and is currently under intense investigation for tissue characterization in several anatomic sites. This article summarizes the evidence regarding the accuracy of USE for malignancy in the head and neck. Currently, most published data pertains to small pilot studies with varied methodologies.

Ultrasound elastography in the head and neck. Part I. Basic principles and practical aspects.

Ultrasound elastography (USE) is a rapidly developing field of imaging that measures and displays tissue elasticity or stiffness properties using ultrasound. In recent years, real-time USE modes have appeared on commercially available clinical ultrasound machines, stimulating an explosion of research into potential oncologic and non-oncologic clinical applications of USE. Preliminary evidence suggests that USE can differentiate benign and malignant conditions accurately in several different tissues.

MR elastography of the head and neck: driver design and initial results.

Purpose: The purpose was to describe the design and fabrication of a driver suitable for magnetic resonance elastography (MRE) of the head and neck and to assess its performance in evaluating human parotid gland, lymph nodes and thyroid at 3.0 T.

Materials And Methods: A head and neck driver was fabricated using a commercial transducer, headrest mould and piston extension.

Shear wave elastography of thyroid nodules in routine clinical practice: preliminary observations and utility for detecting malignancy.

Objective: To evaluate real-time shear wave ultrasound elastography (SWE) for characterizing focal thyroid lesions in routine clinical practice.

Methods: Seventy-four patients with 81 focal thyroid lesions undergoing conventional US with needle cytology also underwent SWE. Absolute and relative SWE stiffness measurements on colour-coded elastograms were correlated with cytology and their discriminatory performances assessed.

A pilot study evaluating real-time shear wave ultrasound elastography of miscellaneous non-nodal neck masses in a routine head and neck ultrasound clinic.

A pilot study was performed to evaluate shear wave ultrasound elastography (SWE) for miscellaneous non-nodal/salivary/thyroid neck lesions. Forty-six lesions undergoing conventional sonography also underwent SWE. Elastic moduli from the stiffest areas in lesions were correlated with diagnosis.

Shear wave elastography of focal salivary gland lesions: preliminary experience in a routine head and neck US clinic.

Objectives: To evaluate shear wave elastography (SWE) for focal lesions in major salivary glands.

Methods: Sixty lesions (49 parotid, 11 submandibular) undergoing routine ultrasound (grey scale and Doppler) also underwent SWE before US-guided needle aspiration for cytology. Quantitative indices of the shear elastic modulus (stiffness) were compared with cytological results.

Current role of radionuclide imaging in differentiated thyroid cancer.

Nuclear medicine plays an integral role in the management of differentiated thyroid cancer. This editorial aims to provide a summary of the current role of radionuclide imaging, including whole body iodine scan and fluorodeoxyglucose (FDG)-positron emission tomography (PET), in the diagnostic work-up and follow-up of patients with thyroid cancer.

Malignant cervical lymphadenopathy: diagnostic accuracy of diffusion-weighted MR imaging.

Purpose: To prospectively determine the diagnostic accuracy of diffusion-weighted magnetic resonance (MR) imaging for discrimination of malignant neck nodes due to lymphoma, squamous cell carcinoma (SCC), and undifferentiated nasopharyngeal carcinoma (NPC), with histologic findings and imaging criteria as reference standards.

Materials And Methods: Ethics committee approval and informed consent were obtained. Patients with malignant lymphadenopathy underwent 1.