Publications by Yolanda Lau

Publications by authors named "Yolanda Lau"

Npj Ment Health Res

November 2024

Emerging research indicates that repetitive negative thinking (RNT), such as worry and rumination, is linked to biomarkers of Alzheimer's disease, highlighting a potential concern for brain health.
The study focused on 134 cognitively healthy older adults, examining whether worry and brooding are associated with neurodegeneration and if these effects differ between men and women.
Results showed that higher levels of brooding correlated with increased neurofilament light chain (NfL) levels, a marker of neurodegeneration, particularly in women, suggesting that RNT may negatively impact brain health, especially in females.

J Psychosom Res

March 2023

The study aimed to explore the relationship between anxiety symptoms and key markers of Alzheimer's disease (AD) neuropathology, specifically amyloid-beta (Aβ) and tau proteins.
After reviewing 27 studies, the meta-analysis found no significant link between self-reported anxiety and either Aβ or tau levels in cognitively healthy adults.
The authors stress the need for larger and longer-term studies to investigate the impact of anxiety onset, severity, and chronicity on AD neuropathology, as well as to explore other potential neurobiological factors.

ACS Nano

February 2022

Understanding how nanoparticles (NPs) are exocytosed from cells helps improve their design for better cellular retention in nanomedicine.
Researchers focused on a specific type of gold NP called dodecyl-PEG-AuNP, which has properties that enhance both cellular uptake and exocytosis.
The study revealed that these NPs exit cells through an unconventional process, also increasing the secretion of certain small extracellular vesicles, with the mechanism being influenced by the amount of dodecyl on the NP surface.

J Autism Dev Disord

May 2013

Autism spectrum disorders (ASD) can be linked to various causes, including structural brain issues like agenesis of the corpus callosum (AgCC).
A study of 106 individuals with AgCC found significant autism traits, showing that 45% of children, 35% of adolescents, and 18% of adults had scores above the autism-screening threshold.
There is a notable relationship between imagination skills and brain connectivity in individuals with AgCC, suggesting that those with this condition should be specifically evaluated for ASD during diagnosis.