Publications by authors named "Yolanda F M Tolentino"
Article Synopsis
- The study aimed to explore the connection between genetic variants in NOD2/CARD15 and TLR4 with Crohn's Disease (CD) and ulcerative colitis (UC) in a population from Rio de Janeiro, where rates of inflammatory bowel disease (IBD) are increasing.
- Researchers analyzed DNA from 67 CD patients, 61 UC patients, and 86 healthy controls, using various genotyping methods to identify specific single-nucleotide polymorphisms (SNPs).
- The findings indicated that the genetic variants did not increase the risk of IBD, but certain SNPs were linked to specific disease characteristics in CD, such as colonic involvement and the necessity for certain treatments, particularly in males.
Innate immunity constitutes the first line of defense, fundamental for the recognition and the initiation of an inflammatory response against microorganisms. The innate immune response relies on the sensing of microbial-associated molecular patterns through specialized structures such as toll-like receptors (TLRs) and the nucleotide oligomerization domain- (NOD-) like receptors (NLRs). In the gut, these tasks are performed by the epithelial barrier and the presence of adaptive and innate immune mechanisms.
View Article and Find Full Text PDFAim: To evaluate the prevalence of hepatitis B virus (HBV) infection in inflammatory bowel disease (IBD) patients that followed up in our hospital and try to identify the possible risk factors involved in this infection transmission.
Methods: This was a cross-sectional study for which 176 patients were selected according to their arrival for the medical interview. All these patients had already IBD diagnosis.